| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Palo Alto Investors LP | 3,547,719 | 124,170,000 | 8.56% | ||
| 2 | PointState Capital LP | 3,503,900 | 122,637,000 | 8.46% | ||
| 3 | FMR LLC | 2,727,310 | 95,456,000 | 6.58% | ||
| 4 | VANGUARD GROUP INC | 2,233,268 | 78,164,000 | 5.39% | ||
| 5 | PFM Health Sciences, LP | 2,078,440 | 72,745,000 | 5.02% | ||
| 6 | GOLDMAN SACHS GROUP INC | 1,869,132 | 65,420,000 | 4.51% | ||
| 7 | Redmile Group, LLC | 1,795,936 | 62,858,000 | 4.33% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,582,895 | 55,401,000 | 3.82% | ||
| 9 | HealthCor Management, L.P. | 1,525,000 | 53,375,000 | 3.68% | ||
| 10 | STATE STREET CORP | 1,483,981 | 51,948,000 | 3.58% | ||
| 11 | Antipodean Advisors LLC | 1,268,658 | 44,403,000 | 3.06% | ||
| 12 | OppenheimerFunds, Inc. | 1,245,510 | 43,593,000 | 3.01% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,173,873 | 41,086,000 | 2.83% | ||
| 14 | BlackRock Fund Advisors | 1,153,986 | 40,390,000 | 2.78% | ||
| 15 | NEA Management Company, LLC | 1,139,890 | 39,896,000 | 2.75% | ||
| 16 | D. E. Shaw & Co., Inc. | 943,519 | 33,023,000 | 2.28% | ||
| 17 | BALYASNY ASSET MANAGEMENT L.P. | 860,204 | 30,107,000 | 2.08% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 770,609 | 26,971,000 | 1.86% | ||
| 19 | ORBIMED ADVISORS LLC | 729,600 | 25,536,000 | 1.76% | ||
| 20 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 612,500 | 21,438,000 | 1.48% | ||
| 21 | LANSDOWNE PARTNERS (UK) LLP | 559,534 | 19,584,000 | 1.35% | ||
| 22 | Visium Asset Management, LP | 536,967 | 18,794,000 | 1.30% | ||
| 23 | BB BIOTECH AG | 528,188 | 18,487,000 | 1.27% | ||
| 24 | Versant Venture Management, LLC | 407,416 | 14,259,560 | 0.98% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 369,567 | 12,935,000 | 0.89% | ||
| 26 | NORTHERN TRUST CORP | 332,299 | 11,630,000 | 0.80% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 277,500 | 9,713,000 | 0.67% | Call | |
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 276,200 | 9,667,000 | 0.67% | Put | |
| 29 | DEUTSCHE BANK AG\ | 231,385 | 8,097,000 | 0.56% | ||
| 30 | TUDOR INVESTMENT CORP ET AL | 225,000 | 7,875,000 | 0.54% | ||
| 31 | NORGES BANK | 222,573 | 7,790,000 | 0.54% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 214,350 | 7,502,000 | 0.52% | ||
| 33 | MORGAN STANLEY | 190,703 | 6,675,000 | 0.46% | ||
| 34 | JPMORGAN CHASE & CO | 179,342 | 6,277,000 | 0.43% | ||
| 35 | Allianz Asset Management GmbH | 170,680 | 5,924,000 | 0.41% | ||
| 36 | Bank of New York Mellon Corp | 158,156 | 5,536,000 | 0.38% | ||
| 37 | GOLDMAN SACHS GROUP INC | 132,400 | 4,634,000 | 0.32% | Call | |
| 38 | CREDIT SUISSE AG/ | 125,000 | 4,375,000 | 0.30% | ||
| 39 | Rock Springs Capital Management LP | 125,000 | 4,375,000 | 0.30% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 46,340 | 4,261,000 | 0.29% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 117,108 | 4,099,000 | 0.28% | ||
| 42 | Point72 Asset Management, L.P. | 117,100 | 4,099,000 | 0.28% | Put | |
| 43 | A.R.T. Advisors, LLC | 113,851 | 3,984,000 | 0.27% | ||
| 44 | Spark Investment Management LLC | 110,000 | 3,850,000 | 0.27% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,020 | 3,816,000 | 0.26% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 97,997 | 3,430,000 | 0.24% | ||
| 47 | Jefferies Group LLC | 95,000 | 3,325,000 | 0.23% | Call | |
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 94,500 | 3,308,000 | 0.23% | ||
| 49 | OXFORD ASSET MANAGEMENT LLP | 93,893 | 3,304,000 | 0.23% | ||
| 50 | BlackRock Investment Management, LLC | 93,422 | 3,270,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
