| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PointState Capital LP | 3,596,180 | 69,047,000 | 8.95% | ||
| 2 | Palo Alto Investors LP | 3,461,365 | 66,458,000 | 8.62% | ||
| 3 | Redmile Group, LLC | 3,099,336 | 59,507,000 | 7.72% | ||
| 4 | VANGUARD GROUP INC | 2,234,421 | 42,902,000 | 5.56% | ||
| 5 | HealthCor Management, L.P. | 2,000,000 | 38,400,000 | 4.98% | ||
| 6 | PFM Health Sciences, LP | 1,874,384 | 35,988,000 | 4.67% | ||
| 7 | STATE STREET CORP | 1,797,874 | 34,525,000 | 4.48% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,564,605 | 30,040,000 | 3.90% | ||
| 9 | FMR LLC | 1,436,456 | 27,580,000 | 3.58% | ||
| 10 | OppenheimerFunds, Inc. | 1,246,660 | 23,936,000 | 3.10% | ||
| 11 | BlackRock Fund Advisors | 1,198,921 | 23,019,000 | 2.99% | ||
| 12 | NEA Management Company, LLC | 1,139,890 | 21,886,000 | 2.84% | ||
| 13 | D. E. Shaw & Co., Inc. | 1,078,921 | 20,716,000 | 2.69% | ||
| 14 | Antipodean Advisors LLC | 1,059,901 | 20,350,000 | 2.64% | ||
| 15 | GOLDMAN SACHS GROUP INC | 1,021,029 | 19,604,000 | 2.54% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 825,085 | 15,842,000 | 2.05% | ||
| 17 | ORBIMED ADVISORS LLC | 660,900 | 12,689,000 | 1.65% | ||
| 18 | Point72 Asset Management, L.P. | 603,100 | 11,580,000 | 1.50% | Put | |
| 19 | LANSDOWNE PARTNERS (UK) LLP | 559,534 | 10,743,000 | 1.39% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 559,400 | 10,740,000 | 1.39% | Call | |
| 21 | BB BIOTECH AG | 528,188 | 10,141,000 | 1.32% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 515,400 | 9,896,000 | 1.28% | ||
| 23 | Visium Asset Management, LP | 500,000 | 9,600,000 | 1.25% | ||
| 24 | Versant Venture Management, LLC | 407,416 | 7,822,387 | 1.01% | ||
| 25 | WESTFIELD CAPITAL MANAGEMENT CO LP | 347,660 | 6,675,000 | 0.87% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 342,200 | 6,570,000 | 0.85% | Put | |
| 27 | NORTHERN TRUST CORP | 341,336 | 6,553,000 | 0.85% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 290,411 | 5,576,000 | 0.72% | ||
| 29 | A.R.T. Advisors, LLC | 283,124 | 5,435,000 | 0.70% | ||
| 30 | NORGES BANK | 222,573 | 4,273,000 | 0.55% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 217,062 | 4,167,000 | 0.54% | ||
| 32 | JPMORGAN CHASE & CO | 216,585 | 4,157,000 | 0.54% | ||
| 33 | DEUTSCHE BANK AG\ | 210,595 | 4,042,000 | 0.52% | ||
| 34 | MORGAN STANLEY | 198,893 | 3,819,000 | 0.50% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 198,178 | 3,805,000 | 0.49% | ||
| 36 | UBS Group AG | 190,000 | 3,648,000 | 0.47% | Call | |
| 37 | Allianz Asset Management GmbH | 186,084 | 3,573,000 | 0.46% | ||
| 38 | CREDIT SUISSE AG/ | 154,786 | 2,971,000 | 0.39% | ||
| 39 | Bank of New York Mellon Corp | 152,430 | 2,927,000 | 0.38% | ||
| 40 | Gruss Capital Management LP | 150,000 | 2,880,000 | 0.37% | ||
| 41 | Rock Springs Capital Management LP | 125,000 | 2,400,000 | 0.31% | ||
| 42 | GOLDMAN SACHS GROUP INC | 114,600 | 2,200,000 | 0.29% | Call | |
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 112,620 | 2,162,000 | 0.28% | ||
| 44 | Spark Investment Management LLC | 112,500 | 2,160,000 | 0.28% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 104,121 | 1,999,000 | 0.26% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 101,742 | 1,954,000 | 0.25% | ||
| 47 | HAYMAN CAPITAL MANAGEMENT, L.P. | 100,000 | 1,920,000 | 0.25% | ||
| 48 | BARCLAYS PLC | 100,000 | 1,900,000 | 0.25% | Call | |
| 49 | BlackRock Investment Management, LLC | 95,001 | 1,824,000 | 0.24% | ||
| 50 | SPHERA FUNDS MANAGEMENT LTD. | 94,500 | 1,814,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
