| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,788,976 | 198,311,000 | 16.77% | ||
| 2 | NEA Management Company, LLC | 2,279,781 | 94,406,000 | 7.98% | ||
| 3 | VANGUARD GROUP INC | 1,343,141 | 55,620,000 | 4.70% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,303,051 | 53,959,000 | 4.56% | ||
| 5 | OppenheimerFunds, Inc. | 1,197,182 | 49,576,000 | 4.19% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,075,000 | 44,516,000 | 3.76% | ||
| 7 | BlackRock Fund Advisors | 958,092 | 39,675,000 | 3.36% | ||
| 8 | Palo Alto Investors LP | 915,321 | 37,903,000 | 3.21% | ||
| 9 | BAKER BROS. ADVISORS LP | 793,221 | 32,847,000 | 2.78% | ||
| 10 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 790,555 | 32,737,000 | 2.77% | ||
| 11 | Visium Asset Management, LP | 789,933 | 32,711,000 | 2.77% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 764,733 | 31,668,000 | 2.68% | ||
| 13 | Redmile Group, LLC | 723,816 | 29,973,000 | 2.53% | ||
| 14 | STATE STREET CORP | 672,645 | 27,852,000 | 2.36% | ||
| 15 | Pentwater Capital Management LP | 577,800 | 23,927,000 | 2.02% | ||
| 16 | BB BIOTECH AG | 558,188 | 23,115,000 | 1.95% | ||
| 17 | FRANKLIN RESOURCES INC | 465,198 | 19,264,000 | 1.63% | ||
| 18 | PFM Health Sciences, LP | 444,734 | 18,416,000 | 1.56% | ||
| 19 | TimesSquare Capital Management, LLC | 422,110 | 17,480,000 | 1.48% | ||
| 20 | GOLDMAN SACHS GROUP INC | 399,500 | 16,543,000 | 1.40% | ||
| 21 | ArrowMark Colorado Holdings LLC | 399,429 | 16,540,000 | 1.40% | ||
| 22 | D. E. Shaw & Co., Inc. | 358,989 | 14,866,000 | 1.26% | ||
| 23 | SECTORAL ASSET MANAGEMENT INC | 314,952 | 13,042,000 | 1.10% | ||
| 24 | JANUS HENDERSON INVESTORS US LLC | 268,977 | 11,138,000 | 0.94% | ||
| 25 | NORTHERN TRUST CORP | 260,070 | 10,769,000 | 0.91% | ||
| 26 | FARALLON CAPITAL MANAGEMENT LLC | 225,000 | 9,317,000 | 0.79% | ||
| 27 | TAMRO Capital Partners LLC | 224,048 | 9,278,000 | 0.78% | ||
| 28 | SUFFOLK CAPITAL MANAGEMENT LLC | 210,933 | 8,735,000 | 0.74% | ||
| 29 | QVT Financial LP | 209,735 | 8,685,000 | 0.73% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 208,500 | 8,634,000 | 0.73% | Put | |
| 31 | VOYA INVESTMENT MANAGEMENT LLC | 206,835 | 8,565,000 | 0.72% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 188,300 | 7,797,000 | 0.66% | Call | |
| 33 | NORGES BANK | 176,987 | 7,329,000 | 0.62% | ||
| 34 | BARCLAYS PLC | 175,400 | 7,191,000 | 0.61% | Put | |
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 162,975 | 6,748,000 | 0.57% | ||
| 36 | Numeric Investors LLC | 145,600 | 6,029,000 | 0.51% | ||
| 37 | Invesco Ltd. | 142,789 | 5,913,000 | 0.50% | ||
| 38 | Bank of New York Mellon Corp | 132,946 | 5,506,000 | 0.47% | ||
| 39 | Opaleye Management Inc. | 130,000 | 5,369,000 | 0.45% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,140 | 5,306,000 | 0.45% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 123,524 | 5,115,000 | 0.43% | ||
| 42 | LORD, ABBETT & CO. LLC | 123,153 | 5,100,000 | 0.43% | ||
| 43 | CREDIT SUISSE AG/ | 123,018 | 5,094,000 | 0.43% | ||
| 44 | RUSSELL FRANK CO/ | 123,717 | 4,665,000 | 0.39% | ||
| 45 | SPHERA FUNDS MANAGEMENT LTD. | 105,000 | 4,348,000 | 0.37% | ||
| 46 | BNP Paribas Asset Management Holding S.A. | 91,249 | 3,779,000 | 0.32% | ||
| 47 | BARCLAYS PLC | 90,970 | 3,730,000 | 0.32% | ||
| 48 | Rhenman & Partners Asset Management AB | 90,000 | 3,727,000 | 0.32% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 82,501 | 3,416,000 | 0.29% | ||
| 50 | DEUTSCHE BANK AG\ | 79,851 | 3,305,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
