| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BROWN CAPITAL MANAGEMENT LLC | 8,783,162 | 42,686,000 | 9.87% | ||
| 2 | ArrowMark Colorado Holdings LLC | 7,639,140 | 37,126,000 | 8.59% | ||
| 3 | Camber Capital Management LP | 7,500,000 | 36,450,000 | 8.43% | ||
| 4 | VANGUARD GROUP INC | 6,638,302 | 32,262,000 | 7.46% | ||
| 5 | Redmile Group, LLC | 6,368,299 | 30,950,000 | 7.16% | ||
| 6 | PFM Health Sciences, LP | 5,599,466 | 27,213,000 | 6.29% | ||
| 7 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 5,244,360 | 25,488,000 | 5.89% | ||
| 8 | BlackRock Finance, Inc. | 4,983,675 | 24,222,000 | 5.60% | ||
| 9 | NEA Management Company, LLC | 2,490,204 | 12,102,000 | 2.80% | ||
| 10 | Essex Woodlands Management, Inc. | 1,257,468 | 11,699,000 | 2.71% | ||
| 11 | MACKENZIE FINANCIAL CORP | 2,123,931 | 10,322,000 | 2.39% | ||
| 12 | Elk Creek Partners, LLC | 2,087,238 | 10,144,000 | 2.35% | ||
| 13 | STATE STREET CORP | 1,951,432 | 9,483,000 | 2.19% | ||
| 14 | Rhenman & Partners Asset Management AB | 1,575,000 | 7,655,000 | 1.77% | ||
| 15 | BNP Paribas Asset Management Holding S.A. | 1,550,539 | 7,536,000 | 1.74% | ||
| 16 | PALISADE CAPITAL MANAGEMENT, LP | 1,231,437 | 5,985,000 | 1.38% | ||
| 17 | NEW YORK STATE COMMON RETIREMENT FUND | 1,220,399 | 5,931,000 | 1.37% | ||
| 18 | MPM ASSET MANAGEMENT LLC | 1,121,447 | 5,450,000 | 1.26% | ||
| 19 | NORTHERN TRUST CORP | 1,104,943 | 5,369,000 | 1.24% | ||
| 20 | Lombard Odier Asset Management (USA) Corp | 1,100,000 | 5,346,000 | 1.24% | ||
| 21 | D. E. Shaw & Co., Inc. | 1,020,205 | 4,958,000 | 1.15% | ||
| 22 | AXA S.A. | 962,787 | 4,679,000 | 1.08% | ||
| 23 | PICTET ASSET MANAGEMENT LTD | 894,318 | 4,311,000 | 1.00% | ||
| 24 | STEPHENS INC /AR/ | 845,016 | 4,107,000 | 0.95% | ||
| 25 | FIL Ltd | 832,224 | 4,045,000 | 0.94% | ||
| 26 | Bank of New York Mellon Corp | 824,928 | 4,009,000 | 0.93% | ||
| 27 | ALTRINSIC GLOBAL ADVISORS LLC | 790,000 | 3,839,000 | 0.89% | ||
| 28 | Broadfin Capital, LLC | 779,341 | 3,788,000 | 0.88% | ||
| 29 | WELLINGTON MANAGEMENT GROUP LLP | 737,560 | 3,585,000 | 0.83% | ||
| 30 | Cortina Asset Management, LLC | 725,661 | 3,527,000 | 0.82% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 685,661 | 3,332,000 | 0.77% | ||
| 32 | NORGES BANK | 623,376 | 3,030,000 | 0.70% | ||
| 33 | C WorldWide Group Holding A/S | 501,006 | 2,435,000 | 0.56% | ||
| 34 | GOLDMAN SACHS GROUP INC | 493,590 | 2,399,000 | 0.55% | ||
| 35 | Sio Capital Management, LLC | 493,060 | 2,396,000 | 0.55% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 324,193 | 1,576,000 | 0.36% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 321,309 | 1,562,000 | 0.36% | ||
| 38 | Nationwide Fund Advisors | 258,787 | 1,258,000 | 0.29% | ||
| 39 | GAM Holding AG | 235,700 | 1,146,000 | 0.27% | ||
| 40 | Candriam S.C.A. | 220,000 | 1,069,000 | 0.25% | ||
| 41 | TEACHERS ADVISORS, LLC | 198,912 | 967,000 | 0.22% | ||
| 42 | MORGAN STANLEY | 192,703 | 937,000 | 0.22% | ||
| 43 | DEUTSCHE BANK AG\ | 187,626 | 911,000 | 0.21% | ||
| 44 | MARSHALL WACE NORTH AMERICA, L.P. | 173,939 | 870,000 | 0.20% | ||
| 45 | A.R.T. Advisors, LLC | 161,791 | 786,000 | 0.18% | ||
| 46 | GW&K Investment Management, LLC | 160,460 | 780,000 | 0.18% | ||
| 47 | AMERIPRISE FINANCIAL INC | 155,399 | 755,000 | 0.17% | ||
| 48 | WELLS FARGO & COMPANY/MN | 149,559 | 726,000 | 0.17% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 145,685 | 708,000 | 0.16% | ||
| 50 | Swiss National Bank | 137,900 | 670,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
