| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 1,206,459 | 15,213,000 | 18.43% | ||
| 2 | FRANKLIN RESOURCES INC | 687,000 | 8,663,000 | 10.49% | ||
| 3 | Point72 Asset Management, L.P. | 534,200 | 6,736,000 | 8.16% | ||
| 4 | BAKER BROS. ADVISORS LP | 451,496 | 5,693,000 | 6.90% | ||
| 5 | VANGUARD GROUP INC | 407,212 | 5,135,000 | 6.22% | ||
| 6 | Informed Momentum Co LLC | 303,142 | 3,823,000 | 4.63% | ||
| 7 | WALL STREET ASSOCIATES | 293,800 | 3,705,000 | 4.49% | ||
| 8 | Ghost Tree Capital, LLC | 280,966 | 3,543,000 | 4.29% | ||
| 9 | SENZAR ASSET MANAGEMENT, LLC | 261,200 | 3,294,000 | 3.99% | ||
| 10 | UBS AG | 260,172 | 3,281,000 | 3.97% | ||
| 11 | BLACKROCK ADVISORS LLC | 206,264 | 2,601,000 | 3.15% | ||
| 12 | PRINCIPAL FINANCIAL GROUP INC | 178,400 | 2,250,000 | 2.73% | ||
| 13 | TURNER INVESTMENTS LLC | 175,370 | 2,211,000 | 2.68% | ||
| 14 | Bank of New York Mellon Corp | 172,882 | 2,180,000 | 2.64% | ||
| 15 | PUTNAM INVESTMENTS LLC | 163,131 | 2,057,000 | 2.49% | ||
| 16 | RUSSELL FRANK CO/ | 113,840 | 1,436,000 | 1.74% | ||
| 17 | Alyeska Investment Group, L.P. | 102,280 | 1,290,000 | 1.56% | ||
| 18 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 85,000 | 1,072,000 | 1.30% | ||
| 19 | BlackRock Group LTD | 73,455 | 926,000 | 1.12% | ||
| 20 | AMERIPRISE FINANCIAL INC | 66,758 | 842,000 | 1.02% | ||
| 21 | Spark Investment Management LLC | 66,800 | 839,000 | 1.02% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 60,246 | 760,000 | 0.92% | ||
| 23 | GOLDMAN SACHS GROUP INC | 54,631 | 689,000 | 0.83% | ||
| 24 | FMR LLC | 33,953 | 428,000 | 0.52% | ||
| 25 | Weiss Multi-Strategy Advisers LLC | 30,000 | 378,000 | 0.46% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 26,167 | 329,000 | 0.40% | ||
| 27 | TFS CAPITAL LLC | 24,098 | 304,000 | 0.37% | ||
| 28 | BlackRock Finance, Inc. | 23,500 | 296,000 | 0.36% | ||
| 29 | SPHERA FUNDS MANAGEMENT LTD. | 22,700 | 286,000 | 0.35% | ||
| 30 | A.R.T. Advisors, LLC | 20,305 | 256,000 | 0.31% | ||
| 31 | BlackRock Fund Advisors | 18,786 | 237,000 | 0.29% | ||
| 32 | DEUTSCHE BANK AG\ | 18,265 | 230,000 | 0.28% | ||
| 33 | SHEPHERD KAPLAN KROCHUK, LLC | 15,002 | 189,000 | 0.23% | ||
| 34 | IRIDIAN ASSET MANAGEMENT LLC/CT | 14,280 | 180,000 | 0.22% | ||
| 35 | Quantitative Systematic Strategies LLC | 12,885 | 174,000 | 0.21% | ||
| 36 | WELLS FARGO & COMPANY/MN | 13,700 | 173,000 | 0.21% | ||
| 37 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 13,500 | 170,000 | 0.21% | ||
| 38 | BANQUE PICTET & CIE SA | 13,197 | 166,000 | 0.20% | ||
| 39 | NORTHERN TRUST CORP | 11,872 | 150,000 | 0.18% | ||
| 40 | CREDIT SUISSE AG/ | 10,187 | 128,000 | 0.16% | ||
| 41 | MORGAN STANLEY | 3,218 | 41,000 | 0.05% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 3,196 | 40,000 | 0.05% | ||
| 43 | PRELUDE CAPITAL MANAGEMENT, LLC | 3,100 | 39,000 | 0.05% | ||
| 44 | Creative Planning | 3,000 | 38,000 | 0.05% | ||
| 45 | BlackRock Japan Co. Ltd | 2,521 | 32,000 | 0.04% | ||
| 46 | OPTIMUM INVESTMENT ADVISORS | 1,500 | 19,000 | 0.02% | ||
| 47 | ROYAL BANK OF CANADA | 1,300 | 16,000 | 0.02% | ||
| 48 | BlackRock Investment Management, LLC | 1,106 | 14,000 | 0.02% | ||
| 49 | Winfield Associates, Inc. | 1,000 | 13,000 | 0.02% | ||
| 50 | BARCLAYS PLC | 72 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
