| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,755,318 | 30,942,000 | 20.10% | ||
| 2 | SENZAR ASSET MANAGEMENT, LLC | 800,788 | 8,992,849 | 5.84% | ||
| 3 | BlackRock Fund Advisors | 712,064 | 7,996,000 | 5.19% | ||
| 4 | FRANKLIN RESOURCES INC | 687,000 | 7,715,000 | 5.01% | ||
| 5 | INGALLS & SNYDER LLC | 624,500 | 7,013,000 | 4.56% | ||
| 6 | Numeric Investors LLC | 618,598 | 6,947,000 | 4.51% | ||
| 7 | VANGUARD GROUP INC | 606,359 | 6,809,000 | 4.42% | ||
| 8 | BAKER BROS. ADVISORS LP | 470,058 | 5,279,000 | 3.43% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 423,197 | 4,753,000 | 3.09% | ||
| 10 | Point72 Asset Management, L.P. | 404,479 | 4,542,000 | 2.95% | ||
| 11 | STATE STREET CORP | 329,769 | 3,708,000 | 2.41% | ||
| 12 | DIMENSIONAL FUND ADVISORS LP | 328,467 | 3,689,000 | 2.40% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 284,421 | 3,194,000 | 2.07% | ||
| 14 | ACADIAN ASSET MANAGEMENT LLC | 275,138 | 3,091,000 | 2.01% | ||
| 15 | Spark Investment Management LLC | 273,400 | 3,070,000 | 1.99% | ||
| 16 | PRUDENTIAL FINANCIAL INC | 230,990 | 2,594,000 | 1.68% | ||
| 17 | UBS Group AG | 219,192 | 2,461,000 | 1.60% | ||
| 18 | NORTHERN TRUST CORP | 209,754 | 2,356,000 | 1.53% | ||
| 19 | OXFORD ASSET MANAGEMENT LLP | 195,384 | 2,194,000 | 1.43% | ||
| 20 | NEXTHERA CAPITAL LP | 183,000 | 2,055,000 | 1.33% | ||
| 21 | PUTNAM INVESTMENTS LLC | 163,131 | 1,832,000 | 1.19% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 161,300 | 1,811,000 | 1.18% | ||
| 23 | Allianz Asset Management GmbH | 159,968 | 1,796,000 | 1.17% | ||
| 24 | MORGAN STANLEY | 153,839 | 1,728,000 | 1.12% | ||
| 25 | GSA CAPITAL PARTNERS LLP | 150,748 | 1,693,000 | 1.10% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 140,469 | 1,577,000 | 1.02% | ||
| 27 | Bank of New York Mellon Corp | 125,269 | 1,407,000 | 0.91% | ||
| 28 | PRINCIPAL FINANCIAL GROUP INC | 112,700 | 1,266,000 | 0.82% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 106,406 | 1,195,000 | 0.78% | ||
| 30 | AWM Investment Company, Inc. | 100,000 | 1,123,000 | 0.73% | ||
| 31 | EMERALD ACQUISITION LTD. | 88,230 | 991,000 | 0.64% | ||
| 32 | DEUTSCHE BANK AG\ | 86,335 | 968,000 | 0.63% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 85,000 | 955,000 | 0.62% | ||
| 34 | Invesco Ltd. | 77,994 | 876,000 | 0.57% | ||
| 35 | RAMSEY QUANTITATIVE SYSTEMS | 73,383 | 824,000 | 0.54% | ||
| 36 | BLACKROCK ADVISORS LLC | 71,332 | 801,000 | 0.52% | ||
| 37 | DAFNA Capital Management LLC | 66,968 | 752,000 | 0.49% | ||
| 38 | BlackRock Investment Management, LLC | 64,532 | 725,000 | 0.47% | ||
| 39 | Fisher Asset Management, LLC | 55,934 | 669,000 | 0.43% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 58,498 | 657,000 | 0.43% | ||
| 41 | Shinko Asset Management Co., Ltd. | 55,934 | 628,000 | 0.41% | ||
| 42 | FMR LLC | 55,175 | 620,000 | 0.40% | ||
| 43 | PNC FINANCIAL SERVICES GROUP, INC. | 51,109 | 574,000 | 0.37% | ||
| 44 | State of New Jersey Common Pension Fund D | 40,000 | 449,000 | 0.29% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 39,226 | 441,000 | 0.29% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 37,469 | 421,000 | 0.27% | ||
| 47 | Nationwide Fund Advisors | 37,420 | 420,000 | 0.27% | ||
| 48 | CREDIT SUISSE AG/ | 34,894 | 392,000 | 0.25% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,570 | 388,000 | 0.25% | ||
| 50 | WELLS FARGO & COMPANY/MN | 31,999 | 359,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
