| 1 |
BVF INC/IL |
1,206,459 |
16,070,000 |
16.26% |
|
|
| 2 |
SENZAR ASSET MANAGEMENT, LLC |
866,200 |
11,538,000 |
11.68% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
687,000 |
9,151,000 |
9.26% |
|
|
| 4 |
BAKER BROS. ADVISORS LP |
505,418 |
6,732,000 |
6.81% |
|
|
| 5 |
Point72 Asset Management, L.P. |
500,000 |
6,660,000 |
6.74% |
|
|
| 6 |
VANGUARD GROUP INC |
350,863 |
4,674,000 |
4.73% |
|
|
| 7 |
WALL STREET ASSOCIATES |
293,800 |
3,913,000 |
3.96% |
|
|
| 8 |
UBS Group AG |
272,020 |
3,623,000 |
3.67% |
|
|
| 9 |
QVT Financial LP |
259,999 |
3,377,000 |
3.42% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
242,080 |
3,225,000 |
3.26% |
|
|
| 11 |
BLACKROCK ADVISORS LLC |
240,649 |
3,206,000 |
3.24% |
|
|
| 12 |
BlackRock Fund Advisors |
232,904 |
3,102,000 |
3.14% |
|
|
| 13 |
PRINCIPAL FINANCIAL GROUP INC |
174,900 |
2,330,000 |
2.36% |
|
|
| 14 |
PUTNAM INVESTMENTS LLC |
163,131 |
2,173,000 |
2.20% |
|
|
| 15 |
SPHERA FUNDS MANAGEMENT LTD. |
150,000 |
1,998,000 |
2.02% |
|
|
| 16 |
Bank of New York Mellon Corp |
134,646 |
1,794,000 |
1.82% |
|
|
| 17 |
TFS CAPITAL LLC |
124,502 |
1,658,000 |
1.68% |
|
|
| 18 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
113,894 |
1,517,000 |
1.54% |
|
|
| 19 |
Spark Investment Management LLC |
110,500 |
1,468,000 |
1.49% |
|
|
| 20 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
85,000 |
1,181,000 |
1.20% |
|
|
| 21 |
TURNER INVESTMENTS LLC |
80,195 |
1,068,000 |
1.08% |
|
|
| 22 |
Granite Point Capital Management, L.P. |
70,264 |
936,000 |
0.95% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
63,187 |
842,000 |
0.85% |
|
|
| 24 |
CITADEL ADVISORS LLC |
59,417 |
791,000 |
0.80% |
|
|
| 25 |
TWO SIGMA INVESTMENTS, LP |
45,163 |
602,000 |
0.61% |
|
|
| 26 |
BlackRock Group LTD |
43,568 |
580,000 |
0.59% |
|
|
| 27 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
43,500 |
579,000 |
0.59% |
|
|
| 28 |
WELLS FARGO & COMPANY/MN |
33,873 |
451,000 |
0.46% |
|
|
| 29 |
GEODE CAPITAL MANAGEMENT, LLC |
30,861 |
411,000 |
0.42% |
|
|
| 30 |
Weiss Multi-Strategy Advisers LLC |
29,000 |
386,000 |
0.39% |
|
|
| 31 |
CREDIT SUISSE AG/ |
24,659 |
329,000 |
0.33% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
19,511 |
260,000 |
0.26% |
|
|
| 33 |
SSI INVESTMENT MANAGEMENT LLC |
18,700 |
249,000 |
0.25% |
|
|
| 34 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
17,880 |
238,000 |
0.24% |
|
|
| 35 |
SHEPHERD KAPLAN KROCHUK, LLC |
15,002 |
200,000 |
0.20% |
|
|
| 36 |
Cubist Systematic Strategies, LLC |
13,866 |
185,000 |
0.19% |
|
|
| 37 |
Connor, Clark & Lunn Investment Management Ltd. |
13,500 |
180,000 |
0.18% |
|
|
| 38 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,138 |
175,000 |
0.18% |
|
|
| 39 |
ProShare Advisors LLC |
12,044 |
160,000 |
0.16% |
|
|
| 40 |
NORTHERN TRUST CORP |
11,872 |
158,000 |
0.16% |
|
|
| 41 |
BlackRock Finance, Inc. |
10,868 |
145,000 |
0.15% |
|
|
| 42 |
IRIDIAN ASSET MANAGEMENT LLC/CT |
10,850 |
145,000 |
0.15% |
|
|
| 43 |
BANK OF AMERICA CORP /DE/ |
6,940 |
92,000 |
0.09% |
|
|
| 44 |
CITIGROUP INC |
3,958 |
53,000 |
0.05% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
3,545 |
46,000 |
0.05% |
|
|
| 46 |
BlackRock Japan Co. Ltd |
3,468 |
46,000 |
0.05% |
|
|
| 47 |
MORGAN STANLEY |
3,218 |
43,000 |
0.04% |
|
|
| 48 |
OPTIMUM INVESTMENT ADVISORS |
1,500 |
20,000 |
0.02% |
|
|
| 49 |
PRELUDE CAPITAL MANAGEMENT, LLC |
1,400 |
19,000 |
0.02% |
|
|
| 50 |
BlackRock Investment Management, LLC |
1,106 |
15,000 |
0.02% |
|
|
