| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,723,210 | 27,532,000 | 20.64% | ||
| 2 | INGALLS & SNYDER LLC | 894,687 | 9,045,000 | 6.78% | ||
| 3 | BlackRock Fund Advisors | 759,002 | 7,674,000 | 5.75% | ||
| 4 | FRANKLIN RESOURCES INC | 687,000 | 6,946,000 | 5.21% | ||
| 5 | VANGUARD GROUP INC | 626,258 | 6,331,000 | 4.75% | ||
| 6 | Numeric Investors LLC | 583,253 | 5,897,000 | 4.42% | ||
| 7 | SENZAR ASSET MANAGEMENT, LLC | 572,388 | 5,786,843 | 4.34% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 415,632 | 4,202,000 | 3.15% | ||
| 9 | Point72 Asset Management, L.P. | 414,479 | 4,190,000 | 3.14% | ||
| 10 | STATE STREET CORP | 336,815 | 3,406,000 | 2.55% | ||
| 11 | Alyeska Investment Group, L.P. | 330,837 | 3,345,000 | 2.51% | ||
| 12 | DIMENSIONAL FUND ADVISORS LP | 323,724 | 3,272,000 | 2.45% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 323,404 | 3,270,000 | 2.45% | ||
| 14 | BAKER BROS. ADVISORS LP | 316,976 | 3,205,000 | 2.40% | ||
| 15 | NORTHERN TRUST CORP | 210,923 | 2,132,000 | 1.60% | ||
| 16 | PRUDENTIAL FINANCIAL INC | 208,530 | 2,108,000 | 1.58% | ||
| 17 | UBS Group AG | 180,575 | 1,825,000 | 1.37% | ||
| 18 | Spark Investment Management LLC | 178,900 | 1,808,000 | 1.36% | ||
| 19 | NEXTHERA CAPITAL LP | 167,866 | 1,697,000 | 1.27% | ||
| 20 | PUTNAM INVESTMENTS LLC | 161,531 | 1,633,000 | 1.22% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 148,228 | 1,498,000 | 1.12% | ||
| 22 | Allianz Asset Management GmbH | 147,847 | 1,495,000 | 1.12% | ||
| 23 | DEUTSCHE BANK AG\ | 146,304 | 1,478,000 | 1.11% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 116,962 | 1,182,000 | 0.89% | ||
| 25 | PRINCIPAL FINANCIAL GROUP INC | 113,684 | 1,149,000 | 0.86% | ||
| 26 | Bank of New York Mellon Corp | 111,411 | 1,126,000 | 0.84% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 104,547 | 1,057,000 | 0.79% | ||
| 28 | AWM Investment Company, Inc. | 100,000 | 1,011,000 | 0.76% | ||
| 29 | MORGAN STANLEY | 97,365 | 985,000 | 0.74% | ||
| 30 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 85,000 | 859,000 | 0.64% | ||
| 31 | FMR LLC | 84,944 | 859,000 | 0.64% | ||
| 32 | Invesco Ltd. | 78,845 | 796,000 | 0.60% | ||
| 33 | SECOR Capital Advisors, LP | 73,236 | 740,000 | 0.55% | ||
| 34 | BlackRock Investment Management, LLC | 71,478 | 723,000 | 0.54% | ||
| 35 | BLACKROCK ADVISORS LLC | 69,658 | 704,000 | 0.53% | ||
| 36 | EMERALD ACQUISITION LTD. | 67,881 | 686,000 | 0.51% | ||
| 37 | DAFNA Capital Management LLC | 66,968 | 677,000 | 0.51% | ||
| 38 | ACADIAN ASSET MANAGEMENT LLC | 65,484 | 661,000 | 0.50% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 58,921 | 596,000 | 0.45% | ||
| 40 | GSA CAPITAL PARTNERS LLP | 53,105 | 537,000 | 0.40% | ||
| 41 | OXFORD ASSET MANAGEMENT LLP | 49,104 | 496,000 | 0.37% | ||
| 42 | D. E. Shaw & Co., Inc. | 40,503 | 409,000 | 0.31% | ||
| 43 | State of New Jersey Common Pension Fund D | 40,000 | 404,000 | 0.30% | ||
| 44 | CREDIT SUISSE AG/ | 37,454 | 378,000 | 0.28% | ||
| 45 | Nationwide Fund Advisors | 36,450 | 369,000 | 0.28% | ||
| 46 | Fisher Asset Management, LLC | 36,163 | 366,000 | 0.27% | ||
| 47 | Shinko Asset Management Co., Ltd. | 36,163 | 366,000 | 0.27% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,870 | 353,000 | 0.26% | ||
| 49 | WELLS FARGO & COMPANY/MN | 32,135 | 324,000 | 0.24% | ||
| 50 | JACOBS LEVY EQUITY MANAGEMENT, INC | 31,852 | 322,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
