| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,232,014 | 42,341,000 | 16.49% | ||
| 2 | SENZAR ASSET MANAGEMENT, LLC | 1,432,617 | 27,176,744 | 10.59% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 915,625 | 17,369,000 | 6.77% | ||
| 4 | FRANKLIN RESOURCES INC | 687,000 | 13,032,000 | 5.08% | ||
| 5 | BlackRock Fund Advisors | 671,334 | 12,735,000 | 4.96% | ||
| 6 | VANGUARD GROUP INC | 535,269 | 10,153,000 | 3.95% | ||
| 7 | Numeric Investors LLC | 531,137 | 10,076,000 | 3.92% | ||
| 8 | BAKER BROS. ADVISORS LP | 495,908 | 9,407,000 | 3.66% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 462,745 | 8,778,000 | 3.42% | ||
| 10 | OXFORD ASSET MANAGEMENT LLP | 313,938 | 5,993,000 | 2.33% | ||
| 11 | Spark Investment Management LLC | 311,200 | 5,903,000 | 2.30% | ||
| 12 | UBS Group AG | 247,515 | 4,695,000 | 1.83% | ||
| 13 | STATE STREET CORP | 224,559 | 4,260,000 | 1.66% | ||
| 14 | DIMENSIONAL FUND ADVISORS LP | 224,348 | 4,256,000 | 1.66% | ||
| 15 | PRUDENTIAL FINANCIAL INC | 217,100 | 4,118,000 | 1.60% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 188,889 | 3,583,000 | 1.40% | ||
| 17 | NORTHERN TRUST CORP | 186,387 | 3,536,000 | 1.38% | ||
| 18 | NEXTHERA CAPITAL LP | 183,000 | 3,472,000 | 1.35% | ||
| 19 | FMR LLC | 180,925 | 3,432,000 | 1.34% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 180,000 | 3,415,000 | 1.33% | ||
| 21 | MORGAN STANLEY | 178,502 | 3,386,000 | 1.32% | ||
| 22 | Allianz Asset Management GmbH | 164,073 | 3,112,000 | 1.21% | ||
| 23 | PUTNAM INVESTMENTS LLC | 163,131 | 3,095,000 | 1.21% | ||
| 24 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 148,835 | 2,823,000 | 1.10% | ||
| 25 | Informed Momentum Co LLC | 133,317 | 2,529,000 | 0.99% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 129,779 | 2,461,000 | 0.96% | ||
| 27 | Bank of New York Mellon Corp | 127,183 | 2,412,000 | 0.94% | ||
| 28 | Invesco Ltd. | 118,115 | 2,241,000 | 0.87% | ||
| 29 | PRINCIPAL FINANCIAL GROUP INC | 115,600 | 2,193,000 | 0.85% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 109,170 | 2,071,000 | 0.81% | ||
| 31 | AQR CAPITAL MANAGEMENT LLC | 108,276 | 2,054,000 | 0.80% | ||
| 32 | TFS CAPITAL LLC | 104,134 | 1,975,000 | 0.77% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 103,700 | 1,967,000 | 0.77% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 103,170 | 1,957,000 | 0.76% | ||
| 35 | CITADEL ADVISORS LLC | 90,726 | 1,721,000 | 0.67% | ||
| 36 | GSA CAPITAL PARTNERS LLP | 78,641 | 1,492,000 | 0.58% | ||
| 37 | BLACKROCK ADVISORS LLC | 70,197 | 1,332,000 | 0.52% | ||
| 38 | A.R.T. Advisors, LLC | 68,645 | 1,302,000 | 0.51% | ||
| 39 | Fisher Asset Management, LLC | 55,934 | 1,061,000 | 0.41% | ||
| 40 | Shinko Asset Management Co., Ltd. | 55,934 | 1,061,000 | 0.41% | ||
| 41 | BlackRock Investment Management, LLC | 54,822 | 1,040,000 | 0.41% | ||
| 42 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 43,700 | 829,000 | 0.32% | ||
| 43 | RUSSELL FRANK CO/ | 43,773 | 823,000 | 0.32% | ||
| 44 | ACADIAN ASSET MANAGEMENT LLC | 43,107 | 818,000 | 0.32% | ||
| 45 | State of New Jersey Common Pension Fund D | 40,000 | 759,000 | 0.30% | ||
| 46 | AMERICAN CENTURY COMPANIES INC | 39,589 | 751,000 | 0.29% | ||
| 47 | DEUTSCHE BANK AG\ | 39,228 | 742,000 | 0.29% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,679 | 564,000 | 0.22% | ||
| 49 | Frontier Wealth Management LLC | 29,670 | 563,000 | 0.22% | ||
| 50 | GLOBEFLEX CAPITAL L P | 29,400 | 558,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
