| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,755,318 | 37,638,000 | 19.85% | ||
| 2 | SENZAR ASSET MANAGEMENT, LLC | 1,471,693 | 20,103,326 | 10.60% | ||
| 3 | BlackRock Fund Advisors | 687,035 | 9,385,000 | 4.95% | ||
| 4 | FRANKLIN RESOURCES INC | 687,000 | 9,384,000 | 4.95% | ||
| 5 | VANGUARD GROUP INC | 582,474 | 7,957,000 | 4.20% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 567,868 | 7,757,000 | 4.09% | ||
| 7 | Numeric Investors LLC | 501,579 | 6,852,000 | 3.61% | ||
| 8 | BAKER BROS. ADVISORS LP | 495,908 | 6,774,000 | 3.57% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 405,949 | 5,545,000 | 2.92% | ||
| 10 | Point72 Asset Management, L.P. | 350,372 | 4,786,000 | 2.52% | ||
| 11 | STATE STREET CORP | 331,605 | 4,531,000 | 2.39% | ||
| 12 | DIMENSIONAL FUND ADVISORS LP | 318,015 | 4,343,000 | 2.29% | ||
| 13 | Spark Investment Management LLC | 303,500 | 4,145,000 | 2.19% | ||
| 14 | MORGAN STANLEY | 269,116 | 3,677,000 | 1.94% | ||
| 15 | PRUDENTIAL FINANCIAL INC | 241,790 | 3,303,000 | 1.74% | ||
| 16 | NORTHERN TRUST CORP | 238,125 | 3,253,000 | 1.72% | ||
| 17 | UBS Group AG | 230,638 | 3,151,000 | 1.66% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 208,894 | 2,853,000 | 1.50% | ||
| 19 | NEXTHERA CAPITAL LP | 183,000 | 2,500,000 | 1.32% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 169,200 | 2,311,000 | 1.22% | ||
| 21 | PUTNAM INVESTMENTS LLC | 163,131 | 2,228,000 | 1.18% | ||
| 22 | Allianz Asset Management GmbH | 152,050 | 2,077,000 | 1.10% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 140,421 | 1,918,000 | 1.01% | ||
| 24 | TFS CAPITAL LLC | 133,184 | 1,819,000 | 0.96% | ||
| 25 | Bank of New York Mellon Corp | 122,608 | 1,675,000 | 0.88% | ||
| 26 | Informed Momentum Co LLC | 120,423 | 1,645,000 | 0.87% | ||
| 27 | PRINCIPAL FINANCIAL GROUP INC | 115,600 | 1,579,000 | 0.83% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 105,016 | 1,435,000 | 0.76% | ||
| 29 | ACADIAN ASSET MANAGEMENT LLC | 102,403 | 1,399,000 | 0.74% | ||
| 30 | Invesco Ltd. | 102,140 | 1,395,000 | 0.74% | ||
| 31 | AWM Investment Company, Inc. | 100,000 | 1,366,000 | 0.72% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 85,000 | 1,161,000 | 0.61% | ||
| 33 | BLACKROCK ADVISORS LLC | 69,823 | 954,000 | 0.50% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 66,786 | 912,000 | 0.48% | ||
| 35 | Shinko Asset Management Co., Ltd. | 55,934 | 764,000 | 0.40% | ||
| 36 | BlackRock Investment Management, LLC | 55,931 | 764,000 | 0.40% | ||
| 37 | Fisher Asset Management, LLC | 55,934 | 759,000 | 0.40% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 55,255 | 755,000 | 0.40% | ||
| 39 | PNC FINANCIAL SERVICES GROUP, INC. | 50,401 | 689,000 | 0.36% | ||
| 40 | Trexquant Investment LP | 49,568 | 677,000 | 0.36% | ||
| 41 | GSA CAPITAL PARTNERS LLP | 45,561 | 622,000 | 0.33% | ||
| 42 | DEUTSCHE BANK AG\ | 45,170 | 614,000 | 0.32% | ||
| 43 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 43,500 | 594,000 | 0.31% | ||
| 44 | CITADEL ADVISORS LLC | 42,474 | 580,000 | 0.31% | ||
| 45 | State of New Jersey Common Pension Fund D | 40,000 | 546,000 | 0.29% | ||
| 46 | A.R.T. Advisors, LLC | 39,445 | 538,000 | 0.28% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 39,226 | 536,000 | 0.28% | ||
| 48 | Nationwide Fund Advisors | 37,098 | 507,000 | 0.27% | ||
| 49 | DEERE & CO | 36,951 | 505,000 | 0.27% | ||
| 50 | RUSSELL FRANK CO/ | 36,623 | 501,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
