| 1 |
BVF INC/IL |
1,340,659 |
20,304,000 |
13.21% |
|
|
| 2 |
SENZAR ASSET MANAGEMENT, LLC |
1,116,100 |
16,903,000 |
11.00% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
687,000 |
10,405,000 |
6.77% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
660,000 |
9,996,000 |
6.50% |
|
|
| 5 |
Point72 Asset Management, L.P. |
525,200 |
7,954,000 |
5.18% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
495,908 |
7,511,000 |
4.89% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
480,222 |
7,273,000 |
4.73% |
|
|
| 8 |
SPHERA FUNDS MANAGEMENT LTD. |
375,000 |
5,679,000 |
3.70% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
371,822 |
5,631,000 |
3.66% |
|
|
| 10 |
VANGUARD GROUP INC |
366,863 |
5,555,000 |
3.61% |
|
|
| 11 |
WALL STREET ASSOCIATES |
286,100 |
4,333,000 |
2.82% |
|
|
| 12 |
UBS Group AG |
285,799 |
4,328,000 |
2.82% |
|
|
| 13 |
QVT Financial LP |
259,999 |
3,938,000 |
2.56% |
|
|
| 14 |
BlackRock Fund Advisors |
249,650 |
3,781,000 |
2.46% |
|
|
| 15 |
PRINCIPAL FINANCIAL GROUP INC |
174,900 |
2,648,000 |
1.72% |
|
|
| 16 |
PUTNAM INVESTMENTS LLC |
163,131 |
2,471,000 |
1.61% |
|
|
| 17 |
TURNER INVESTMENTS LLC |
151,155 |
2,289,000 |
1.49% |
|
|
| 18 |
ARROWGRASS CAPITAL PARTNERS (US) LP |
147,568 |
2,235,000 |
1.45% |
|
|
| 19 |
BLACKROCK ADVISORS LLC |
132,043 |
2,000,000 |
1.30% |
|
|
| 20 |
Bank of New York Mellon Corp |
131,981 |
1,999,000 |
1.30% |
|
|
| 21 |
Alyeska Investment Group, L.P. |
130,000 |
1,969,000 |
1.28% |
|
|
| 22 |
Granite Point Capital Management, L.P. |
130,000 |
1,969,000 |
1.28% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
112,806 |
1,708,000 |
1.11% |
|
|
| 24 |
Spark Investment Management LLC |
102,300 |
1,548,000 |
1.01% |
|
|
| 25 |
EverPoint Asset Management, LLC |
100,700 |
1,525,000 |
0.99% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
100,000 |
1,515,000 |
0.99% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
83,148 |
1,259,000 |
0.82% |
|
|
| 28 |
Informed Momentum Co LLC |
82,434 |
1,248,000 |
0.81% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
85,000 |
1,181,000 |
0.77% |
|
|
| 30 |
TWO SIGMA INVESTMENTS, LP |
70,096 |
1,062,000 |
0.69% |
|
|
| 31 |
MONASHEE INVESTMENT MANAGEMENT LLC |
67,500 |
1,022,000 |
0.66% |
|
|
| 32 |
CREDIT SUISSE AG/ |
63,753 |
965,000 |
0.63% |
|
|
| 33 |
TUDOR INVESTMENT CORP ET AL |
51,025 |
773,000 |
0.50% |
|
|
| 34 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
50,000 |
757,000 |
0.49% |
|
|
| 35 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
43,500 |
659,000 |
0.43% |
|
|
| 36 |
TFS CAPITAL LLC |
35,398 |
536,000 |
0.35% |
|
|
| 37 |
PANAGORA ASSET MANAGEMENT INC |
32,658 |
495,000 |
0.32% |
|
|
| 38 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
32,421 |
491,000 |
0.32% |
|
|
| 39 |
RENAISSANCE TECHNOLOGIES LLC |
29,900 |
453,000 |
0.29% |
|
|
| 40 |
TWO SIGMA ADVISERS, LP |
27,400 |
415,000 |
0.27% |
|
|
| 41 |
GOLDMAN SACHS GROUP INC |
25,124 |
381,000 |
0.25% |
|
|
| 42 |
Connor, Clark & Lunn Investment Management Ltd. |
25,000 |
379,000 |
0.25% |
|
|
| 43 |
Weiss Multi-Strategy Advisers LLC |
25,000 |
379,000 |
0.25% |
|
|
| 44 |
MOORE CAPITAL MANAGEMENT, LP |
25,000 |
379,000 |
0.25% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
24,047 |
365,000 |
0.24% |
|
|
| 46 |
BlackRock Group LTD |
23,299 |
353,000 |
0.23% |
|
|
| 47 |
BlueCrest Capital Management Ltd |
22,542 |
341,000 |
0.22% |
|
|
| 48 |
JANE STREET GROUP, LLC |
20,330 |
308,000 |
0.20% |
|
|
| 49 |
NORTHERN TRUST CORP |
19,466 |
295,000 |
0.19% |
|
|
| 50 |
CITADEL ADVISORS LLC |
19,333 |
293,000 |
0.19% |
|
|
