| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,255,168 | 42,330,000 | 16.01% | ||
| 2 | SENZAR ASSET MANAGEMENT, LLC | 1,645,673 | 30,889,282 | 11.68% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 971,019 | 18,226,000 | 6.89% | ||
| 4 | BlackRock Fund Advisors | 716,418 | 13,447,000 | 5.09% | ||
| 5 | FRANKLIN RESOURCES INC | 687,000 | 12,895,000 | 4.88% | ||
| 6 | VANGUARD GROUP INC | 521,688 | 9,792,000 | 3.70% | ||
| 7 | BAKER BROS. ADVISORS LP | 495,908 | 9,308,000 | 3.52% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 417,331 | 7,833,000 | 2.96% | ||
| 9 | TFS CAPITAL LLC | 382,196 | 7,174,000 | 2.71% | ||
| 10 | MORGAN STANLEY | 370,226 | 6,949,000 | 2.63% | ||
| 11 | JENNISON ASSOCIATES LLC | 337,193 | 6,329,000 | 2.39% | ||
| 12 | Spark Investment Management LLC | 306,300 | 5,743,000 | 2.17% | ||
| 13 | UBS Group AG | 280,574 | 5,266,000 | 1.99% | ||
| 14 | ALPS ADVISORS INC | 25,871 | 4,856,000 | 1.84% | ||
| 15 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 236,517 | 4,439,000 | 1.68% | ||
| 16 | Bank of New York Mellon Corp | 234,205 | 4,396,000 | 1.66% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 3,754,000 | 1.42% | ||
| 18 | PRINCIPAL FINANCIAL GROUP INC | 197,700 | 3,711,000 | 1.40% | ||
| 19 | DEUTSCHE BANK AG\ | 194,150 | 3,642,000 | 1.38% | ||
| 20 | STATE STREET CORP | 192,814 | 3,617,000 | 1.37% | ||
| 21 | Allianz Asset Management GmbH | 192,210 | 3,608,000 | 1.36% | ||
| 22 | NORTHERN TRUST CORP | 178,687 | 3,354,000 | 1.27% | ||
| 23 | FMR LLC | 175,925 | 3,302,000 | 1.25% | ||
| 24 | PUTNAM INVESTMENTS LLC | 163,131 | 3,062,000 | 1.16% | ||
| 25 | Alyeska Investment Group, L.P. | 162,534 | 3,051,000 | 1.15% | ||
| 26 | AQR CAPITAL MANAGEMENT LLC | 158,081 | 2,967,000 | 1.12% | ||
| 27 | Informed Momentum Co LLC | 134,121 | 2,517,000 | 0.95% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 127,386 | 2,391,000 | 0.90% | ||
| 29 | Invesco Ltd. | 107,419 | 2,016,000 | 0.76% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 100,054 | 1,878,000 | 0.71% | ||
| 31 | PRUDENTIAL FINANCIAL INC | 92,900 | 1,744,000 | 0.66% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 85,000 | 1,595,000 | 0.60% | ||
| 33 | BLACKROCK ADVISORS LLC | 83,008 | 1,558,000 | 0.59% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 81,270 | 1,525,000 | 0.58% | ||
| 35 | J. Goldman & Co LP | 74,000 | 1,388,000 | 0.53% | Put | |
| 36 | GSA CAPITAL PARTNERS LLP | 71,387 | 1,340,000 | 0.51% | ||
| 37 | Shinko Asset Management Co., Ltd. | 55,934 | 1,050,000 | 0.40% | ||
| 38 | Fisher Asset Management, LLC | 55,934 | 1,050,000 | 0.40% | ||
| 39 | BlackRock Investment Management, LLC | 54,379 | 1,021,000 | 0.39% | ||
| 40 | Numeric Investors LLC | 47,890 | 899,000 | 0.34% | ||
| 41 | Granite Point Capital Management, L.P. | 47,097 | 884,000 | 0.33% | ||
| 42 | RUSSELL FRANK CO/ | 44,826 | 841,000 | 0.32% | ||
| 43 | DIMENSIONAL FUND ADVISORS LP | 44,350 | 832,000 | 0.31% | ||
| 44 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 43,500 | 817,000 | 0.31% | ||
| 45 | PRICE T ROWE ASSOCIATES INC /MD/ | 39,705 | 745,000 | 0.28% | ||
| 46 | A.R.T. Advisors, LLC | 39,523 | 741,000 | 0.28% | ||
| 47 | CITADEL ADVISORS LLC | 38,793 | 728,000 | 0.28% | ||
| 48 | CREDIT SUISSE AG/ | 38,415 | 721,000 | 0.27% | ||
| 49 | Nine Chapters Capital Management LLC | 38,000 | 713,000 | 0.27% | ||
| 50 | Connor, Clark & Lunn Investment Management Ltd. | 31,700 | 595,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
