| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,616,249 | 26,921,000 | 20.20% | ||
| 2 | INGALLS & SNYDER LLC | 1,068,300 | 10,993,000 | 8.25% | ||
| 3 | FRANKLIN RESOURCES INC | 687,000 | 7,069,000 | 5.30% | ||
| 4 | VANGUARD GROUP INC | 642,820 | 6,615,000 | 4.96% | ||
| 5 | BlackRock Fund Advisors | 545,973 | 5,618,000 | 4.21% | ||
| 6 | Cormorant Asset Management, LP | 538,422 | 5,540,000 | 4.16% | ||
| 7 | Numeric Investors LLC | 459,381 | 4,727,000 | 3.55% | ||
| 8 | RENAISSANCE TECHNOLOGIES LLC | 435,800 | 4,484,000 | 3.36% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 433,052 | 4,456,000 | 3.34% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 400,588 | 4,122,000 | 3.09% | ||
| 11 | Alyeska Investment Group, L.P. | 356,215 | 3,665,000 | 2.75% | ||
| 12 | STATE STREET CORP | 349,505 | 3,594,000 | 2.70% | ||
| 13 | DIMENSIONAL FUND ADVISORS LP | 309,361 | 3,183,000 | 2.39% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 232,896 | 2,396,000 | 1.80% | ||
| 15 | NORTHERN TRUST CORP | 218,844 | 2,252,000 | 1.69% | ||
| 16 | PRUDENTIAL FINANCIAL INC | 200,630 | 2,065,000 | 1.55% | ||
| 17 | UBS Group AG | 176,451 | 1,816,000 | 1.36% | ||
| 18 | NEXTHERA CAPITAL LP | 167,866 | 1,727,000 | 1.30% | ||
| 19 | PUTNAM INVESTMENTS LLC | 161,531 | 1,662,000 | 1.25% | ||
| 20 | BAKER BROS. ADVISORS LP | 152,964 | 1,574,000 | 1.18% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 141,902 | 1,460,000 | 1.10% | ||
| 22 | MORGAN STANLEY | 130,296 | 1,341,000 | 1.01% | ||
| 23 | Allianz Asset Management GmbH | 126,128 | 1,298,000 | 0.97% | ||
| 24 | Bank of New York Mellon Corp | 119,271 | 1,228,000 | 0.92% | ||
| 25 | PRINCIPAL FINANCIAL GROUP INC | 115,100 | 1,184,000 | 0.89% | ||
| 26 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 113,627 | 1,169,000 | 0.88% | ||
| 27 | AWM Investment Company, Inc. | 110,000 | 1,132,000 | 0.85% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 106,105 | 1,092,000 | 0.82% | ||
| 29 | FMR LLC | 100,000 | 1,029,000 | 0.77% | ||
| 30 | DEUTSCHE BANK AG\ | 92,766 | 952,000 | 0.71% | ||
| 31 | SCHONFELD STRATEGIC ADVISORS LLC | 90,000 | 926,000 | 0.69% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 85,000 | 875,000 | 0.66% | ||
| 33 | ALGERT GLOBAL LLC | 81,812 | 842,000 | 0.63% | ||
| 34 | BlackRock Investment Management, LLC | 71,478 | 736,000 | 0.55% | ||
| 35 | BLACKROCK ADVISORS LLC | 69,847 | 719,000 | 0.54% | ||
| 36 | DAFNA Capital Management LLC | 66,968 | 689,000 | 0.52% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 62,181 | 640,000 | 0.48% | ||
| 38 | JACOBS LEVY EQUITY MANAGEMENT, INC | 58,314 | 600,000 | 0.45% | ||
| 39 | D. E. Shaw & Co., Inc. | 58,288 | 600,000 | 0.45% | ||
| 40 | GSA CAPITAL PARTNERS LLP | 56,309 | 579,000 | 0.43% | ||
| 41 | Invesco Ltd. | 55,874 | 575,000 | 0.43% | ||
| 42 | TURNER INVESTMENTS LLC | 50,000 | 515,000 | 0.39% | ||
| 43 | RUSSELL INVESTMENTS GROUP, LTD. | 42,704 | 440,000 | 0.33% | ||
| 44 | JPMORGAN CHASE & CO | 41,391 | 426,000 | 0.32% | ||
| 45 | State of New Jersey Common Pension Fund D | 40,000 | 412,000 | 0.31% | ||
| 46 | WELLS FARGO & COMPANY/MN | 39,226 | 403,000 | 0.30% | ||
| 47 | Fisher Asset Management, LLC | 36,163 | 372,000 | 0.28% | ||
| 48 | Squarepoint Ops LLC | 35,325 | 363,000 | 0.27% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,970 | 350,000 | 0.26% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,837 | 348,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
