| 1 |
BVF INC/IL |
2,521,452 |
37,544,000 |
21.71% |
|
|
| 2 |
SENZAR ASSET MANAGEMENT, LLC |
1,557,534 |
23,192,000 |
13.41% |
|
|
| 3 |
BlackRock Fund Advisors |
688,981 |
10,259,000 |
5.93% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
687,000 |
10,229,000 |
5.91% |
|
|
| 5 |
RA CAPITAL MANAGEMENT, L.P. |
668,406 |
9,953,000 |
5.76% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
564,810 |
8,410,000 |
4.86% |
|
|
| 7 |
Point72 Asset Management, L.P. |
555,000 |
8,264,000 |
4.78% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
495,908 |
7,384,000 |
4.27% |
|
|
| 9 |
VANGUARD GROUP INC |
423,238 |
6,302,000 |
3.64% |
|
|
| 10 |
JENNISON ASSOCIATES LLC |
334,686 |
4,983,000 |
2.88% |
|
|
| 11 |
UBS Group AG |
282,798 |
4,211,000 |
2.44% |
|
|
| 12 |
WALL STREET ASSOCIATES |
275,500 |
4,102,000 |
2.37% |
|
|
| 13 |
Bank of New York Mellon Corp |
253,486 |
3,774,000 |
2.18% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
212,709 |
3,167,000 |
1.83% |
|
|
| 15 |
PRINCIPAL FINANCIAL GROUP INC |
193,100 |
2,875,000 |
1.66% |
|
|
| 16 |
Spark Investment Management LLC |
171,400 |
2,552,000 |
1.48% |
|
|
| 17 |
PUTNAM INVESTMENTS LLC |
163,131 |
2,429,000 |
1.40% |
|
|
| 18 |
TURNER INVESTMENTS LLC |
140,620 |
2,094,000 |
1.21% |
|
|
| 19 |
Alyeska Investment Group, L.P. |
135,261 |
2,014,000 |
1.16% |
|
|
| 20 |
STATE STREET CORP |
123,706 |
1,839,000 |
1.06% |
|
|
| 21 |
BANK OF AMERICA CORP /DE/ |
100,006 |
1,489,000 |
0.86% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
94,395 |
1,405,000 |
0.81% |
|
|
| 23 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
85,000 |
1,266,000 |
0.73% |
|
|
| 24 |
Informed Momentum Co LLC |
82,319 |
1,226,000 |
0.71% |
|
|
| 25 |
BLACKROCK ADVISORS LLC |
54,827 |
816,000 |
0.47% |
|
|
| 26 |
BlackRock Investment Management, LLC |
54,338 |
809,000 |
0.47% |
|
|
| 27 |
Granite Point Capital Management, L.P. |
52,331 |
779,000 |
0.45% |
|
|
| 28 |
TFS CAPITAL LLC |
51,527 |
767,000 |
0.44% |
|
|
| 29 |
NORTHERN TRUST CORP |
49,065 |
731,000 |
0.42% |
|
|
| 30 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
43,500 |
648,000 |
0.37% |
|
|
| 31 |
AQR CAPITAL MANAGEMENT LLC |
31,499 |
469,000 |
0.27% |
|
|
| 32 |
BOURGEON CAPITAL MANAGEMENT LLC |
30,000 |
447,000 |
0.26% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
28,090 |
418,000 |
0.24% |
|
|
| 34 |
CREDIT SUISSE AG/ |
27,171 |
404,000 |
0.23% |
|
|
| 35 |
GOLDMAN SACHS GROUP INC |
26,956 |
401,000 |
0.23% |
|
|
| 36 |
Connor, Clark & Lunn Investment Management Ltd. |
26,900 |
401,000 |
0.23% |
|
|
| 37 |
IRIDIAN ASSET MANAGEMENT LLC/CT |
24,392 |
363,000 |
0.21% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
22,268 |
332,000 |
0.19% |
|
|
| 39 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,722 |
324,000 |
0.19% |
|
|
| 40 |
Frontier Wealth Management LLC |
21,330 |
318,000 |
0.18% |
|
|
| 41 |
ProShare Advisors LLC |
19,296 |
287,000 |
0.17% |
|
|
| 42 |
PANAGORA ASSET MANAGEMENT INC |
19,003 |
283,000 |
0.16% |
|
|
| 43 |
Virtu KCG Holdings LLC |
18,935 |
282,000 |
0.16% |
|
|
| 44 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
16,093 |
240,000 |
0.14% |
|
|
| 45 |
SPHERA FUNDS MANAGEMENT LTD. |
15,858 |
236,000 |
0.14% |
|
|
| 46 |
SHEPHERD KAPLAN KROCHUK, LLC |
15,002 |
223,000 |
0.13% |
|
|
| 47 |
RHUMBLINE ADVISERS |
13,180 |
196,000 |
0.11% |
|
|
| 48 |
METROPOLITAN LIFE INSURANCE CO/NY |
11,833 |
176,000 |
0.10% |
|
|
| 49 |
DekaBank Deutsche Girozentrale |
10,500 |
156,000 |
0.09% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,357 |
154,000 |
0.09% |
|
|
