| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,258,475 | 75,249,000 | 22.57% | ||
| 2 | Broadfin Capital, LLC | 5,005,613 | 71,630,000 | 21.48% | ||
| 3 | JPMORGAN CHASE & CO | 1,275,916 | 18,258,000 | 5.48% | ||
| 4 | KENNEDY CAPITAL MANAGEMENT LLC | 1,032,238 | 14,771,000 | 4.43% | ||
| 5 | CLOUGH CAPITAL PARTNERS L P | 887,650 | 12,702,000 | 3.81% | ||
| 6 | Rock Springs Capital Management LP | 735,000 | 10,518,000 | 3.15% | ||
| 7 | JENNISON ASSOCIATES LLC | 712,283 | 10,193,000 | 3.06% | ||
| 8 | D. E. Shaw & Co., Inc. | 696,535 | 9,967,000 | 2.99% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 634,217 | 9,076,000 | 2.72% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 610,000 | 8,729,000 | 2.62% | ||
| 11 | BROWN CAPITAL MANAGEMENT LLC | 561,578 | 8,036,000 | 2.41% | ||
| 12 | VHCP Management, LLC | 500,000 | 7,155,000 | 2.15% | ||
| 13 | TURNER INVESTMENTS LLC | 472,988 | 6,769,000 | 2.03% | ||
| 14 | Alyeska Investment Group, L.P. | 467,902 | 6,696,000 | 2.01% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 462,100 | 6,613,000 | 1.98% | ||
| 16 | MORGAN STANLEY | 440,888 | 6,309,000 | 1.89% | ||
| 17 | PointState Capital LP | 400,000 | 5,724,000 | 1.72% | ||
| 18 | CLEARBRIDGE, LLC | 361,890 | 5,179,000 | 1.55% | ||
| 19 | FMR LLC | 330,780 | 4,733,000 | 1.42% | ||
| 20 | Weiss Multi-Strategy Advisers LLC | 300,000 | 4,293,000 | 1.29% | ||
| 21 | BAILARD, INC. | 235,000 | 3,363,000 | 1.01% | ||
| 22 | Bank of New York Mellon Corp | 207,319 | 2,967,000 | 0.89% | ||
| 23 | Lisanti Capital Growth, LLC | 140,272 | 2,007,000 | 0.60% | ||
| 24 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 129,736 | 1,856,000 | 0.56% | ||
| 25 | DEUTSCHE BANK AG\ | 121,207 | 1,733,000 | 0.52% | ||
| 26 | WALL STREET ASSOCIATES | 120,852 | 1,729,000 | 0.52% | ||
| 27 | MARSHALL WACE, LLP | 114,327 | 1,636,000 | 0.49% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 112,074 | 1,604,000 | 0.48% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,700 | 1,012,000 | 0.30% | Call | |
| 30 | COMERICA BANK | 64,977 | 930,000 | 0.28% | ||
| 31 | Neuberger Berman Group LLC | 63,300 | 905,000 | 0.27% | ||
| 32 | Atika Capital Management LLC | 62,000 | 887,000 | 0.27% | ||
| 33 | IRIDIAN ASSET MANAGEMENT LLC/CT | 58,270 | 834,000 | 0.25% | ||
| 34 | Independence Capital Asset Partners, LLC | 54,500 | 780,000 | 0.23% | ||
| 35 | UBS AG | 54,174 | 775,000 | 0.23% | ||
| 36 | Index Management Solutions, LLC | 52,327 | 749,000 | 0.22% | ||
| 37 | THOMPSON SIEGEL & WALMSLEY LLC | 49,500 | 708,000 | 0.21% | ||
| 38 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 45,821 | 656,000 | 0.20% | ||
| 39 | Janney Montgomery Scott LLC | 41,500 | 593,865 | 0.18% | ||
| 40 | EATON VANCE MANAGEMENT | 34,700 | 497,000 | 0.15% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,500 | 451,000 | 0.14% | Put | |
| 42 | BOURGEON CAPITAL MANAGEMENT LLC | 31,200 | 446,000 | 0.13% | ||
| 43 | STATE STREET CORP | 31,008 | 444,000 | 0.13% | ||
| 44 | STIFEL FINANCIAL CORP | 26,085 | 373,000 | 0.11% | ||
| 45 | D.A. DAVIDSON & CO. | 26,000 | 372,000 | 0.11% | ||
| 46 | ASCEND CAPITAL, LLC | 23,270 | 333,000 | 0.10% | ||
| 47 | CREDIT AGRICOLE S A | 21,056 | 301,000 | 0.09% | ||
| 48 | TD ASSET MANAGEMENT INC | 17,800 | 255,000 | 0.08% | ||
| 49 | CREDIT SUISSE AG/ | 15,213 | 218,000 | 0.07% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,799 | 197,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
