| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,394,464 | 47,197,000 | 14.92% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,072,809 | 43,742,000 | 13.83% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,197,404 | 25,599,000 | 8.09% | ||
| 4 | Bank of New York Mellon Corp | 1,818,579 | 19,532,000 | 6.17% | ||
| 5 | ACADIAN ASSET MANAGEMENT LLC | 1,617,223 | 17,372,000 | 5.49% | ||
| 6 | DEUTSCHE BANK AG\ | 1,411,671 | 15,159,000 | 4.79% | ||
| 7 | J. Goldman & Co LP | 1,297,415 | 13,934,000 | 4.40% | ||
| 8 | FALCON POINT CAPITAL, LLC | 1,015,841 | 10,910,000 | 3.45% | ||
| 9 | MORGAN STANLEY | 934,722 | 10,040,000 | 3.17% | ||
| 10 | Portolan Capital Management, LLC | 862,294 | 9,261,000 | 2.93% | ||
| 11 | BROWN CAPITAL MANAGEMENT LLC | 790,206 | 8,487,000 | 2.68% | ||
| 12 | Tekla Capital Management LLC | 624,288 | 6,705,000 | 2.12% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 610,372 | 6,555,000 | 2.07% | ||
| 14 | EMERALD ACQUISITION LTD. | 607,967 | 6,530,000 | 2.06% | ||
| 15 | BlackRock Fund Advisors | 510,864 | 5,487,000 | 1.73% | ||
| 16 | VHCP Management, LLC | 500,000 | 5,370,000 | 1.70% | ||
| 17 | Point72 Asset Management, L.P. | 461,839 | 4,960,000 | 1.57% | ||
| 18 | PNC FINANCIAL SERVICES GROUP, INC. | 460,210 | 4,943,000 | 1.56% | ||
| 19 | JW Asset Management, LLC | 444,439 | 4,773,000 | 1.51% | ||
| 20 | HEARTLAND ADVISORS INC | 361,045 | 3,878,000 | 1.23% | ||
| 21 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 351,263 | 3,773,000 | 1.19% | ||
| 22 | Ghost Tree Capital, LLC | 350,000 | 3,759,000 | 1.19% | ||
| 23 | ARMISTICE CAPITAL, LLC | 348,003 | 3,738,000 | 1.18% | ||
| 24 | OXFORD ASSET MANAGEMENT LLP | 287,905 | 3,092,000 | 0.98% | ||
| 25 | Asset Management One Co., Ltd. | 251,718 | 2,716,000 | 0.86% | ||
| 26 | Janney Montgomery Scott LLC | 221,600 | 2,530,000 | 0.80% | ||
| 27 | KELLEHER FINANCIAL ADVISORS | 187,650 | 2,015,000 | 0.64% | ||
| 28 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 183,440 | 1,970,000 | 0.62% | ||
| 29 | AMERIPRISE FINANCIAL INC | 165,191 | 1,774,000 | 0.56% | ||
| 30 | D. E. Shaw & Co., Inc. | 153,079 | 1,644,000 | 0.52% | ||
| 31 | STONEPINE CAPITAL MANAGEMENT, LLC | 128,005 | 1,375,000 | 0.43% | ||
| 32 | GAM Holding AG | 119,400 | 1,282,000 | 0.41% | ||
| 33 | TURNER INVESTMENTS LLC | 117,338 | 1,260,000 | 0.40% | ||
| 34 | Candriam S.C.A. | 111,000 | 1,192,000 | 0.38% | ||
| 35 | STIFEL FINANCIAL CORP | 49,000 | 1,187,000 | 0.38% | ||
| 36 | BAILARD, INC. | 103,000 | 1,106,000 | 0.35% | ||
| 37 | KNOTT DAVID M | 99,587 | 1,069,564 | 0.34% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 99,100 | 1,064,000 | 0.34% | ||
| 39 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 77,918 | 837,000 | 0.26% | ||
| 40 | Iguana Healthcare Management, LLC | 75,000 | 806,000 | 0.25% | ||
| 41 | COLUMBUS CIRCLE INVESTORS | 62,813 | 675,000 | 0.21% | ||
| 42 | DEERE & CO | 43,887 | 471,000 | 0.15% | ||
| 43 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 42,033 | 451,000 | 0.14% | ||
| 44 | EATON VANCE MANAGEMENT | 34,700 | 373,000 | 0.12% | ||
| 45 | State of New Jersey Common Pension Fund D | 32,915 | 354,000 | 0.11% | ||
| 46 | STATE STREET CORP | 30,682 | 330,000 | 0.10% | ||
| 47 | ProShare Advisors LLC | 29,957 | 322,000 | 0.10% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 29,714 | 320,000 | 0.10% | ||
| 49 | SMITH ASSET MANAGEMENT GROUP LP | 29,780 | 320,000 | 0.10% | ||
| 50 | CREDIT SUISSE AG/ | 28,152 | 303,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
