| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,394,464 | 53,656,000 | 14.13% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,318,315 | 52,726,000 | 13.88% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,072,809 | 49,729,000 | 13.09% | ||
| 4 | Bank of New York Mellon Corp | 2,619,872 | 31,989,000 | 8.42% | ||
| 5 | DEUTSCHE BANK AG\ | 2,158,645 | 26,356,000 | 6.94% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 876,002 | 14,288,000 | 3.76% | ||
| 7 | Portolan Capital Management, LLC | 1,043,292 | 12,739,000 | 3.35% | ||
| 8 | FALCON POINT CAPITAL, LLC | 735,265 | 8,978,000 | 2.36% | ||
| 9 | MORGAN STANLEY | 719,463 | 8,785,000 | 2.31% | ||
| 10 | J. Goldman & Co LP | 623,000 | 7,607,000 | 2.00% | ||
| 11 | BROWN CAPITAL MANAGEMENT LLC | 578,457 | 7,063,000 | 1.86% | ||
| 12 | KENNEDY CAPITAL MANAGEMENT LLC | 521,553 | 6,368,000 | 1.68% | ||
| 13 | JW Asset Management, LLC | 504,439 | 6,159,000 | 1.62% | ||
| 14 | RUSSELL FRANK CO/ | 422,247 | 6,118,000 | 1.61% | ||
| 15 | VHCP Management, LLC | 500,000 | 6,105,000 | 1.61% | ||
| 16 | Tekla Capital Management LLC | 474,288 | 5,791,000 | 1.52% | ||
| 17 | BlackRock Fund Advisors | 460,862 | 5,627,000 | 1.48% | ||
| 18 | Invesco Ltd. | 444,724 | 5,430,000 | 1.43% | ||
| 19 | SENZAR ASSET MANAGEMENT, LLC | 441,500 | 5,390,715 | 1.42% | ||
| 20 | Asset Management One Co., Ltd. | 296,422 | 4,348,000 | 1.14% | ||
| 21 | JPMORGAN CHASE & CO | 286,232 | 3,495,000 | 0.92% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 254,248 | 3,104,000 | 0.82% | ||
| 23 | Opaleye Management Inc. | 250,000 | 3,053,000 | 0.80% | ||
| 24 | HEARTLAND ADVISORS INC | 250,000 | 3,053,000 | 0.80% | ||
| 25 | TURNER INVESTMENTS LLC | 239,308 | 2,922,000 | 0.77% | ||
| 26 | CHARTWELL INVESTMENT PARTNERS, LLC | 229,268 | 2,799,000 | 0.74% | ||
| 27 | Lombard Odier Asset Management (USA) Corp | 220,000 | 2,686,000 | 0.71% | ||
| 28 | ACADIAN ASSET MANAGEMENT LLC | 175,583 | 2,144,000 | 0.56% | ||
| 29 | SEI INVESTMENTS CO | 174,380 | 2,129,000 | 0.56% | ||
| 30 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 171,500 | 2,094,000 | 0.55% | ||
| 31 | AMERIPRISE FINANCIAL INC | 156,578 | 1,912,000 | 0.50% | ||
| 32 | Candriam S.C.A. | 155,600 | 1,900,000 | 0.50% | ||
| 33 | Sio Capital Management, LLC | 124,017 | 1,514,000 | 0.40% | ||
| 34 | D. E. Shaw & Co., Inc. | 104,896 | 1,281,000 | 0.34% | ||
| 35 | Janney Montgomery Scott LLC | 101,700 | 1,242,000 | 0.33% | ||
| 36 | PEAK6 Group LLC | 100,100 | 1,222,000 | 0.32% | Call | |
| 37 | KNOTT DAVID M | 99,587 | 1,215,957 | 0.32% | ||
| 38 | Allianz Asset Management GmbH | 78,002 | 1,130,000 | 0.30% | ||
| 39 | KELLEHER FINANCIAL ADVISORS | 82,000 | 1,001,000 | 0.26% | ||
| 40 | J. Goldman & Co LP | 80,000 | 977,000 | 0.26% | Put | |
| 41 | COLUMBUS CIRCLE INVESTORS | 73,415 | 896,000 | 0.24% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,200 | 894,000 | 0.24% | Call | |
| 43 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 68,122 | 831,000 | 0.22% | ||
| 44 | Point72 Asset Management, L.P. | 67,012 | 818,000 | 0.22% | ||
| 45 | GAM Holding AG | 59,700 | 729,000 | 0.19% | ||
| 46 | Opus Point Partners Management, LLC | 56,788 | 693,000 | 0.18% | ||
| 47 | THOMPSON SIEGEL & WALMSLEY LLC | 51,550 | 629,000 | 0.17% | ||
| 48 | COMERICA BANK | 58,245 | 595,000 | 0.16% | ||
| 49 | WALL STREET ASSOCIATES | 47,219 | 577,000 | 0.15% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 41,118 | 502,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
