| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,258,475 | 90,078,000 | 20.63% | ||
| 2 | Broadfin Capital, LLC | 5,153,190 | 88,274,000 | 20.22% | ||
| 3 | KENNEDY CAPITAL MANAGEMENT LLC | 1,207,410 | 20,683,000 | 4.74% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,128,000 | 19,323,000 | 4.43% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,095,139 | 18,760,000 | 4.30% | ||
| 6 | JENNISON ASSOCIATES LLC | 711,507 | 12,188,000 | 2.79% | ||
| 7 | Rock Springs Capital Management LP | 675,000 | 11,563,000 | 2.65% | ||
| 8 | D. E. Shaw & Co., Inc. | 662,129 | 11,342,000 | 2.60% | ||
| 9 | CASTLEARK MANAGEMENT LLC | 596,651 | 10,221,000 | 2.34% | ||
| 10 | BROWN CAPITAL MANAGEMENT LLC | 548,445 | 9,395,000 | 2.15% | ||
| 11 | VHCP Management, LLC | 500,000 | 8,565,000 | 1.96% | ||
| 12 | JW Asset Management, LLC | 495,154 | 8,482,000 | 1.94% | ||
| 13 | Alyeska Investment Group, L.P. | 472,875 | 8,100,000 | 1.86% | ||
| 14 | BlackRock Fund Advisors | 442,765 | 7,585,000 | 1.74% | ||
| 15 | MORGAN STANLEY | 414,775 | 7,105,000 | 1.63% | ||
| 16 | March Altus Capital Management LP | 394,897 | 6,765,000 | 1.55% | ||
| 17 | Ghost Tree Capital, LLC | 325,000 | 5,567,000 | 1.28% | ||
| 18 | MARSHALL WACE, LLP | 275,983 | 4,728,000 | 1.08% | ||
| 19 | CLEARBRIDGE, LLC | 273,120 | 4,679,000 | 1.07% | ||
| 20 | Weiss Multi-Strategy Advisers LLC | 270,000 | 4,625,000 | 1.06% | ||
| 21 | TURNER INVESTMENTS LLC | 219,788 | 3,765,000 | 0.86% | ||
| 22 | DEUTSCHE BANK AG\ | 216,624 | 3,710,000 | 0.85% | ||
| 23 | Avoro Capital Advisors LLC | 214,805 | 3,680,000 | 0.84% | ||
| 24 | PERCEPTIVE ADVISORS LLC | 644,111 | 3,678,000 | 0.84% | ||
| 25 | DRIEHAUS CAPITAL MANAGEMENT LLC | 213,405 | 3,656,000 | 0.84% | ||
| 26 | Invesco Ltd. | 208,628 | 3,573,000 | 0.82% | ||
| 27 | Opaleye Management Inc. | 205,000 | 3,512,000 | 0.80% | ||
| 28 | Penn Capital Management Company, LLC | 204,297 | 3,500,000 | 0.80% | ||
| 29 | Candriam S.C.A. | 192,000 | 3,289,000 | 0.75% | ||
| 30 | Bank of New York Mellon Corp | 172,586 | 2,957,000 | 0.68% | ||
| 31 | COMERICA BANK | 162,748 | 2,788,000 | 0.64% | ||
| 32 | BAILARD, INC. | 135,000 | 2,313,000 | 0.53% | ||
| 33 | RUSSELL FRANK CO/ | 128,743 | 2,205,000 | 0.51% | ||
| 34 | Lisanti Capital Growth, LLC | 123,603 | 2,117,000 | 0.48% | ||
| 35 | CHARTWELL INVESTMENT PARTNERS, LLC | 120,707 | 2,068,000 | 0.47% | ||
| 36 | WALL STREET ASSOCIATES | 113,431 | 1,943,000 | 0.45% | ||
| 37 | COLUMBUS CIRCLE INVESTORS | 112,492 | 1,927,000 | 0.44% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 129,674 | 1,898,000 | 0.43% | ||
| 39 | Green Owl Capital Management, LLC | 109,500 | 1,876,000 | 0.43% | ||
| 40 | J. Goldman & Co LP | 103,125 | 1,767,000 | 0.40% | ||
| 41 | FMR LLC | 100,000 | 1,713,000 | 0.39% | ||
| 42 | HIGHLAND CAPITAL MANAGEMENT LP | 99,500 | 1,704,000 | 0.39% | ||
| 43 | Atika Capital Management LLC | 93,000 | 1,593,000 | 0.36% | ||
| 44 | Index Management Solutions, LLC | 63,783 | 1,093,000 | 0.25% | ||
| 45 | Janney Montgomery Scott LLC | 62,955 | 1,078,419 | 0.25% | ||
| 46 | TD ASSET MANAGEMENT INC | 47,900 | 821,000 | 0.19% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,556 | 798,000 | 0.18% | ||
| 48 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 46,401 | 795,000 | 0.18% | ||
| 49 | UBS Group AG | 44,174 | 757,000 | 0.17% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,600 | 730,000 | 0.17% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
