| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,394,464 | 71,674,000 | 14.28% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,341,515 | 70,810,000 | 14.11% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,072,809 | 66,428,000 | 13.24% | ||
| 4 | DEUTSCHE BANK AG\ | 2,107,318 | 34,368,000 | 6.85% | ||
| 5 | Bank of New York Mellon Corp | 1,799,181 | 29,344,000 | 5.85% | ||
| 6 | KENNEDY CAPITAL MANAGEMENT LLC | 1,413,867 | 23,060,000 | 4.59% | ||
| 7 | Portolan Capital Management, LLC | 1,223,979 | 19,963,000 | 3.98% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 788,120 | 12,854,000 | 2.56% | ||
| 9 | JENNISON ASSOCIATES LLC | 726,586 | 11,851,000 | 2.36% | ||
| 10 | LOOMIS SAYLES & CO L P | 607,323 | 9,906,000 | 1.97% | ||
| 11 | JW Asset Management, LLC | 569,819 | 9,294,000 | 1.85% | ||
| 12 | BlackRock Fund Advisors | 561,865 | 9,164,000 | 1.83% | ||
| 13 | BROWN CAPITAL MANAGEMENT LLC | 554,059 | 9,037,000 | 1.80% | ||
| 14 | VHCP Management, LLC | 500,000 | 8,155,000 | 1.62% | ||
| 15 | J. Goldman & Co LP | 412,880 | 6,734,000 | 1.34% | ||
| 16 | FALCON POINT CAPITAL, LLC | 392,820 | 6,407,000 | 1.28% | ||
| 17 | RUSSELL FRANK CO/ | 365,495 | 5,962,000 | 1.19% | ||
| 18 | Invesco Ltd. | 358,675 | 5,850,000 | 1.17% | ||
| 19 | Ghost Tree Capital, LLC | 350,000 | 5,709,000 | 1.14% | ||
| 20 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 323,716 | 5,279,000 | 1.05% | ||
| 21 | Asset Management One Co., Ltd. | 340,000 | 5,225,000 | 1.04% | ||
| 22 | MORGAN STANLEY | 310,932 | 5,071,000 | 1.01% | ||
| 23 | Opaleye Management Inc. | 310,000 | 5,056,000 | 1.01% | ||
| 24 | ACADIAN ASSET MANAGEMENT LLC | 275,227 | 4,492,000 | 0.90% | ||
| 25 | JPMORGAN CHASE & CO | 275,240 | 4,489,000 | 0.89% | ||
| 26 | Sio Capital Management, LLC | 239,698 | 3,909,000 | 0.78% | ||
| 27 | CHARTWELL INVESTMENT PARTNERS, LLC | 234,548 | 3,825,000 | 0.76% | ||
| 28 | Lombard Odier Asset Management (USA) Corp | 193,247 | 3,152,000 | 0.63% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 171,500 | 2,797,000 | 0.56% | ||
| 30 | D. E. Shaw & Co., Inc. | 163,615 | 2,669,000 | 0.53% | ||
| 31 | AMERIPRISE FINANCIAL INC | 161,980 | 2,641,000 | 0.53% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 146,778 | 2,394,000 | 0.48% | ||
| 33 | TURNER INVESTMENTS LLC | 134,968 | 2,201,000 | 0.44% | ||
| 34 | Candriam S.C.A. | 130,600 | 2,130,000 | 0.42% | ||
| 35 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 127,345 | 2,076,000 | 0.41% | ||
| 36 | COMERICA BANK | 107,672 | 1,756,000 | 0.35% | ||
| 37 | COLUMBUS CIRCLE INVESTORS | 103,835 | 1,694,000 | 0.34% | ||
| 38 | EDMOND DE ROTHSCHILD HOLDING S.A. | 90,798 | 1,481,000 | 0.30% | ||
| 39 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 90,798 | 1,481,000 | 0.30% | ||
| 40 | Alyeska Investment Group, L.P. | 83,255 | 1,358,000 | 0.27% | ||
| 41 | Penn Capital Management Company, LLC | 81,163 | 1,324,000 | 0.26% | ||
| 42 | Janney Montgomery Scott LLC | 72,200 | 1,178,000 | 0.23% | ||
| 43 | Trexquant Investment LP | 60,100 | 980,000 | 0.20% | ||
| 44 | GAM Holding AG | 59,700 | 974,000 | 0.19% | ||
| 45 | Allianz Asset Management GmbH | 57,527 | 938,000 | 0.19% | ||
| 46 | Opus Point Partners Management, LLC | 56,788 | 926,000 | 0.18% | ||
| 47 | WALL STREET ASSOCIATES | 49,919 | 814,000 | 0.16% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,900 | 765,000 | 0.15% | Put | |
| 49 | Weiss Multi-Strategy Advisers LLC | 40,000 | 652,000 | 0.13% | ||
| 50 | Quantitative Systematic Strategies LLC | 36,331 | 611,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
