| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,719,959 | 84,865,000 | 16.04% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,072,809 | 73,229,000 | 13.84% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,982,852 | 53,632,000 | 10.14% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 1,831,860 | 32,937,000 | 6.23% | ||
| 5 | KENNEDY CAPITAL MANAGEMENT LLC | 1,444,030 | 25,964,000 | 4.91% | ||
| 6 | Bank of New York Mellon Corp | 1,334,775 | 24,000,000 | 4.54% | ||
| 7 | DEUTSCHE BANK AG\ | 1,166,288 | 20,968,000 | 3.96% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,131,500 | 20,344,000 | 3.85% | ||
| 9 | Sarissa Capital Management LP | 875,000 | 15,733,000 | 2.97% | ||
| 10 | JENNISON ASSOCIATES LLC | 713,770 | 12,834,000 | 2.43% | ||
| 11 | Alyeska Investment Group, L.P. | 637,450 | 11,461,000 | 2.17% | ||
| 12 | JW Asset Management, LLC | 551,562 | 9,917,000 | 1.87% | ||
| 13 | BROWN CAPITAL MANAGEMENT LLC | 548,445 | 9,861,000 | 1.86% | ||
| 14 | VHCP Management, LLC | 500,000 | 8,990,000 | 1.70% | ||
| 15 | BlackRock Fund Advisors | 486,936 | 8,755,000 | 1.66% | ||
| 16 | Rock Springs Capital Management LP | 460,000 | 8,271,000 | 1.56% | ||
| 17 | AMERIPRISE FINANCIAL INC | 452,179 | 8,130,000 | 1.54% | ||
| 18 | Invesco Ltd. | 368,724 | 6,629,000 | 1.25% | ||
| 19 | Point72 Asset Management, L.P. | 355,800 | 6,397,000 | 1.21% | ||
| 20 | RUSSELL FRANK CO/ | 341,597 | 6,142,000 | 1.16% | ||
| 21 | Opaleye Management Inc. | 300,000 | 5,394,000 | 1.02% | ||
| 22 | Asset Management One Co., Ltd. | 289,372 | 5,214,000 | 0.99% | ||
| 23 | Penn Capital Management Company, LLC | 286,915 | 5,159,000 | 0.98% | ||
| 24 | BAILARD, INC. | 245,000 | 4,405,000 | 0.83% | ||
| 25 | SENZAR ASSET MANAGEMENT, LLC | 225,351 | 4,052,000 | 0.77% | ||
| 26 | Avoro Capital Advisors LLC | 215,705 | 3,878,000 | 0.73% | ||
| 27 | Candriam S.C.A. | 208,000 | 3,741,000 | 0.71% | ||
| 28 | Ghost Tree Capital, LLC | 200,000 | 3,596,000 | 0.68% | ||
| 29 | TURNER INVESTMENTS LLC | 158,744 | 2,855,000 | 0.54% | ||
| 30 | Weiss Multi-Strategy Advisers LLC | 129,800 | 2,334,000 | 0.44% | ||
| 31 | COLUMBUS CIRCLE INVESTORS | 128,005 | 2,302,000 | 0.44% | ||
| 32 | Iguana Healthcare Management, LLC | 125,000 | 2,248,000 | 0.42% | ||
| 33 | SUFFOLK CAPITAL MANAGEMENT LLC | 124,753 | 2,243,000 | 0.42% | ||
| 34 | DRIEHAUS CAPITAL MANAGEMENT LLC | 118,042 | 2,122,000 | 0.40% | ||
| 35 | WALL STREET ASSOCIATES | 111,531 | 2,005,000 | 0.38% | ||
| 36 | MORGAN STANLEY | 105,949 | 1,905,000 | 0.36% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 129,674 | 1,898,000 | 0.36% | ||
| 38 | COMERICA BANK | 104,283 | 1,875,000 | 0.35% | ||
| 39 | FALCON POINT CAPITAL, LLC | 103,644 | 1,864,000 | 0.35% | ||
| 40 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 91,278 | 1,641,000 | 0.31% | ||
| 41 | AQR ARBITRAGE LLC | 83,300 | 1,498,000 | 0.28% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,900 | 1,491,000 | 0.28% | Call | |
| 43 | D. E. Shaw & Co., Inc. | 72,265 | 1,299,000 | 0.25% | ||
| 44 | Janney Montgomery Scott LLC | 71,700 | 1,289,000 | 0.24% | ||
| 45 | Trexquant Investment LP | 52,300 | 940,000 | 0.18% | ||
| 46 | TD ASSET MANAGEMENT INC | 52,200 | 939,000 | 0.18% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,000 | 827,000 | 0.16% | Put | |
| 48 | Opus Point Partners Management, LLC | 41,788 | 751,000 | 0.14% | ||
| 49 | OXFORD ASSET MANAGEMENT LLP | 39,413 | 709,000 | 0.13% | ||
| 50 | EATON VANCE MANAGEMENT | 34,700 | 624,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
