| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,975,184 | 105,424,000 | 16.83% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,072,809 | 86,303,000 | 13.78% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 3,586,034 | 75,988,000 | 12.13% | ||
| 4 | Bank of New York Mellon Corp | 1,888,600 | 40,020,000 | 6.39% | ||
| 5 | KENNEDY CAPITAL MANAGEMENT LLC | 1,716,430 | 36,371,000 | 5.81% | ||
| 6 | DEUTSCHE BANK AG\ | 1,675,365 | 35,499,000 | 5.67% | ||
| 7 | Portolan Capital Management, LLC | 895,472 | 18,975,000 | 3.03% | ||
| 8 | JENNISON ASSOCIATES LLC | 720,960 | 15,277,000 | 2.44% | ||
| 9 | Ghost Tree Capital, LLC | 575,000 | 12,184,000 | 1.94% | ||
| 10 | JW Asset Management, LLC | 564,525 | 11,962,000 | 1.91% | ||
| 11 | BROWN CAPITAL MANAGEMENT LLC | 562,026 | 11,909,000 | 1.90% | ||
| 12 | AMERIPRISE FINANCIAL INC | 553,797 | 11,672,000 | 1.86% | ||
| 13 | Invesco Ltd. | 511,509 | 10,839,000 | 1.73% | ||
| 14 | BlackRock Fund Advisors | 507,909 | 10,763,000 | 1.72% | ||
| 15 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 505,624 | 10,714,000 | 1.71% | ||
| 16 | VHCP Management, LLC | 500,000 | 10,595,000 | 1.69% | ||
| 17 | RUSSELL FRANK CO/ | 401,669 | 8,512,000 | 1.36% | ||
| 18 | FALCON POINT CAPITAL, LLC | 382,763 | 8,111,000 | 1.29% | ||
| 19 | Lombard Odier Asset Management (USA) Corp | 335,000 | 7,098,000 | 1.13% | ||
| 20 | Sio Capital Management, LLC | 320,000 | 6,781,000 | 1.08% | ||
| 21 | Asset Management One Co., Ltd. | 321,283 | 6,682,000 | 1.07% | ||
| 22 | Opaleye Management Inc. | 310,000 | 6,569,000 | 1.05% | ||
| 23 | Avoro Capital Advisors LLC | 267,747 | 5,674,000 | 0.91% | ||
| 24 | MORGAN STANLEY | 266,378 | 5,644,000 | 0.90% | ||
| 25 | COMERICA BANK | 251,624 | 5,332,000 | 0.85% | ||
| 26 | CHARTWELL INVESTMENT PARTNERS, LLC | 230,125 | 4,876,000 | 0.78% | ||
| 27 | TURNER INVESTMENTS LLC | 195,245 | 4,137,000 | 0.66% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,174 | 3,712,000 | 0.59% | ||
| 29 | BAILARD, INC. | 155,000 | 3,284,000 | 0.52% | ||
| 30 | Candriam S.C.A. | 132,000 | 2,797,000 | 0.45% | ||
| 31 | SUFFOLK CAPITAL MANAGEMENT LLC | 129,626 | 2,747,000 | 0.44% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,774 | 2,686,000 | 0.43% | ||
| 33 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 121,625 | 2,577,000 | 0.41% | ||
| 34 | Penn Capital Management Company, LLC | 117,322 | 2,486,000 | 0.40% | ||
| 35 | COLUMBUS CIRCLE INVESTORS | 116,409 | 2,467,000 | 0.39% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,500 | 2,384,000 | 0.38% | Call | |
| 37 | D. E. Shaw & Co., Inc. | 104,537 | 2,215,000 | 0.35% | ||
| 38 | WALL STREET ASSOCIATES | 90,731 | 1,923,000 | 0.31% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 85,000 | 1,801,000 | 0.29% | ||
| 40 | Rock Springs Capital Management LP | 75,000 | 1,589,000 | 0.25% | ||
| 41 | Janney Montgomery Scott LLC | 65,300 | 1,383,707 | 0.22% | ||
| 42 | Allianz Asset Management GmbH | 57,527 | 1,219,000 | 0.19% | ||
| 43 | Opus Point Partners Management, LLC | 51,788 | 1,097,000 | 0.18% | ||
| 44 | EDMOND DE ROTHSCHILD HOLDING S.A. | 45,400 | 962,000 | 0.15% | ||
| 45 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 45,400 | 962,000 | 0.15% | ||
| 46 | UBS Group AG | 43,894 | 930,000 | 0.15% | ||
| 47 | Alyeska Investment Group, L.P. | 40,973 | 868,000 | 0.14% | ||
| 48 | CREDIT SUISSE AG/ | 39,484 | 836,000 | 0.13% | ||
| 49 | MILLENNIUM MANAGEMENT LLC | 38,318 | 812,000 | 0.13% | ||
| 50 | EATON VANCE MANAGEMENT | 34,700 | 735,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
