| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,394,464 | 45,658,000 | 18.91% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,072,809 | 42,316,000 | 17.53% | ||
| 3 | Bank of New York Mellon Corp | 1,783,111 | 18,526,000 | 7.67% | ||
| 4 | ACADIAN ASSET MANAGEMENT LLC | 1,654,673 | 17,192,000 | 7.12% | ||
| 5 | DEUTSCHE BANK AG\ | 1,594,332 | 16,564,000 | 6.86% | ||
| 6 | MORGAN STANLEY | 1,212,533 | 12,598,000 | 5.22% | ||
| 7 | BROWN CAPITAL MANAGEMENT LLC | 969,662 | 10,075,000 | 4.17% | ||
| 8 | FALCON POINT CAPITAL, LLC | 887,639 | 9,223,000 | 3.82% | ||
| 9 | ARMISTICE CAPITAL, LLC | 828,000 | 8,603,000 | 3.56% | ||
| 10 | Tekla Capital Management LLC | 624,288 | 6,486,000 | 2.69% | ||
| 11 | Ghost Tree Capital, LLC | 575,000 | 5,974,000 | 2.47% | ||
| 12 | BlackRock Fund Advisors | 565,440 | 5,875,000 | 2.43% | ||
| 13 | VHCP Management, LLC | 500,000 | 5,195,000 | 2.15% | ||
| 14 | JW Asset Management, LLC | 444,439 | 4,618,000 | 1.91% | ||
| 15 | STONEPINE CAPITAL MANAGEMENT, LLC | 326,087 | 3,388,000 | 1.40% | ||
| 16 | RUSSELL INVESTMENTS GROUP, LTD. | 329,239 | 3,312,000 | 1.37% | ||
| 17 | Portolan Capital Management, LLC | 279,351 | 2,902,000 | 1.20% | ||
| 18 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 254,916 | 2,649,000 | 1.10% | ||
| 19 | OXFORD ASSET MANAGEMENT LLP | 244,604 | 2,541,000 | 1.05% | ||
| 20 | D. E. Shaw & Co., Inc. | 236,206 | 2,454,000 | 1.02% | ||
| 21 | KELLEHER FINANCIAL ADVISORS | 193,924 | 2,014,000 | 0.83% | ||
| 22 | AMERIPRISE FINANCIAL INC | 184,075 | 1,912,000 | 0.79% | ||
| 23 | Janney Montgomery Scott LLC | 123,426 | 1,282,000 | 0.53% | ||
| 24 | Sio Capital Management, LLC | 91,413 | 950,000 | 0.39% | ||
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 88,200 | 916,000 | 0.38% | ||
| 26 | GOLDMAN SACHS GROUP INC | 80,934 | 841,000 | 0.35% | ||
| 27 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 77,918 | 810,000 | 0.34% | ||
| 28 | GAM Holding AG | 59,700 | 620,000 | 0.26% | ||
| 29 | TURNER INVESTMENTS LLC | 59,598 | 619,000 | 0.26% | ||
| 30 | STIFEL FINANCIAL CORP | 58,000 | 603,000 | 0.25% | ||
| 31 | COLUMBUS CIRCLE INVESTORS | 49,315 | 512,000 | 0.21% | ||
| 32 | State of New Jersey Common Pension Fund D | 32,915 | 342,000 | 0.14% | ||
| 33 | SMITH ASSET MANAGEMENT GROUP LP | 32,590 | 339,000 | 0.14% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 31,691 | 330,000 | 0.14% | ||
| 35 | CREDIT SUISSE AG/ | 28,931 | 301,000 | 0.12% | ||
| 36 | ProShare Advisors LLC | 26,657 | 277,000 | 0.11% | ||
| 37 | Yorktown Management & Research Co Inc | 25,000 | 260,000 | 0.11% | ||
| 38 | CUTLER GROUP LLC / CA | 21,065 | 218,000 | 0.09% | ||
| 39 | DekaBank Deutsche Girozentrale | 21,100 | 207,000 | 0.09% | ||
| 40 | CONDOR CAPITAL MANAGEMENT | 16,804 | 175,000 | 0.07% | ||
| 41 | CITADEL ADVISORS LLC | 13,643 | 142,000 | 0.06% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,272 | 138,000 | 0.06% | ||
| 43 | SG Americas Securities, LLC | 13,258 | 138,000 | 0.06% | ||
| 44 | Walleye Trading LLC | 13,000 | 135,000 | 0.06% | ||
| 45 | US BANCORP \DE\ | 12,500 | 130,000 | 0.05% | ||
| 46 | Trexquant Investment LP | 12,300 | 128,000 | 0.05% | ||
| 47 | CITIGROUP INC | 11,918 | 124,000 | 0.05% | ||
| 48 | Stanford Investment Group, Inc. | 11,790 | 122,000 | 0.05% | ||
| 49 | SEI INVESTMENTS CO | 10,685 | 111,000 | 0.05% | ||
| 50 | BALDWIN WEALTH PARTNERS LLC/MA | 9,300 | 97,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
