| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,394,464 | 54,491,000 | 15.21% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,072,809 | 50,503,000 | 14.09% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,184,836 | 27,092,000 | 7.56% | ||
| 4 | Bank of New York Mellon Corp | 1,775,587 | 22,017,000 | 6.14% | ||
| 5 | ACADIAN ASSET MANAGEMENT LLC | 1,654,673 | 20,515,000 | 5.72% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,363,711 | 16,910,000 | 4.72% | ||
| 7 | DEUTSCHE BANK AG\ | 1,292,728 | 16,029,000 | 4.47% | ||
| 8 | MORGAN STANLEY | 1,103,494 | 13,683,000 | 3.82% | ||
| 9 | BROWN CAPITAL MANAGEMENT LLC | 926,559 | 11,489,000 | 3.21% | ||
| 10 | J. Goldman & Co LP | 823,000 | 10,205,000 | 2.85% | ||
| 11 | Portolan Capital Management, LLC | 737,529 | 9,145,000 | 2.55% | ||
| 12 | FALCON POINT CAPITAL, LLC | 830,672 | 8,971,000 | 2.50% | ||
| 13 | Tekla Capital Management LLC | 624,288 | 7,741,000 | 2.16% | ||
| 14 | ARMISTICE CAPITAL, LLC | 600,000 | 7,440,000 | 2.08% | ||
| 15 | Ghost Tree Capital, LLC | 575,000 | 7,130,000 | 1.99% | ||
| 16 | BlackRock Fund Advisors | 534,511 | 6,628,000 | 1.85% | ||
| 17 | VHCP Management, LLC | 500,000 | 6,200,000 | 1.73% | ||
| 18 | PNC FINANCIAL SERVICES GROUP, INC. | 496,867 | 6,161,000 | 1.72% | ||
| 19 | JW Asset Management, LLC | 444,439 | 5,511,000 | 1.54% | ||
| 20 | HEARTLAND ADVISORS INC | 400,000 | 4,960,000 | 1.38% | ||
| 21 | EMERALD ACQUISITION LTD. | 337,871 | 4,190,000 | 1.17% | ||
| 22 | OXFORD ASSET MANAGEMENT LLP | 287,549 | 3,566,000 | 1.00% | ||
| 23 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 264,332 | 3,278,000 | 0.91% | ||
| 24 | Asset Management One Co., Ltd. | 245,862 | 2,962,000 | 0.83% | ||
| 25 | D. E. Shaw & Co., Inc. | 220,755 | 2,737,000 | 0.76% | ||
| 26 | Iguana Healthcare Management, LLC | 200,000 | 2,480,000 | 0.69% | ||
| 27 | KELLEHER FINANCIAL ADVISORS | 187,150 | 2,320,000 | 0.65% | ||
| 28 | AMERIPRISE FINANCIAL INC | 176,357 | 2,174,000 | 0.61% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 163,884 | 2,032,000 | 0.57% | ||
| 30 | Janney Montgomery Scott LLC | 135,100 | 1,675,000 | 0.47% | ||
| 31 | BAILARD, INC. | 120,700 | 1,497,000 | 0.42% | ||
| 32 | Candriam S.C.A. | 111,000 | 1,376,000 | 0.38% | ||
| 33 | KNOTT DAVID M | 99,587 | 1,235,000 | 0.34% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 92,700 | 1,150,000 | 0.32% | ||
| 35 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 77,918 | 966,000 | 0.27% | ||
| 36 | TURNER INVESTMENTS LLC | 70,058 | 869,000 | 0.24% | ||
| 37 | GAM Holding AG | 59,700 | 740,000 | 0.21% | ||
| 38 | STIFEL FINANCIAL CORP | 56,000 | 694,000 | 0.19% | ||
| 39 | COLUMBUS CIRCLE INVESTORS | 49,571 | 615,000 | 0.17% | ||
| 40 | DEERE & CO | 43,887 | 544,000 | 0.15% | ||
| 41 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 42,033 | 521,000 | 0.15% | ||
| 42 | EATON VANCE MANAGEMENT | 34,700 | 430,000 | 0.12% | ||
| 43 | State of New Jersey Common Pension Fund D | 32,915 | 408,000 | 0.11% | ||
| 44 | CREDIT SUISSE AG/ | 32,024 | 398,000 | 0.11% | ||
| 45 | GOLDMAN SACHS GROUP INC | 31,626 | 392,000 | 0.11% | ||
| 46 | SMITH ASSET MANAGEMENT GROUP LP | 30,430 | 377,000 | 0.11% | ||
| 47 | STATE STREET CORP | 29,545 | 366,000 | 0.10% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 29,376 | 364,000 | 0.10% | ||
| 49 | ProShare Advisors LLC | 25,439 | 315,000 | 0.09% | ||
| 50 | Yorktown Management & Research Co Inc | 25,000 | 310,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
