| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 2,256,546 | 34,051,000 | 11.87% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 1,967,600 | 29,691,000 | 10.35% | ||
| 3 | FMR LLC | 1,929,609 | 29,118,000 | 10.15% | ||
| 4 | Lombard Odier Asset Management (USA) Corp | 1,550,000 | 23,390,000 | 8.15% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,395,931 | 21,065,000 | 7.34% | ||
| 6 | JPMORGAN CHASE & CO | 1,284,132 | 19,378,000 | 6.75% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 944,870 | 14,258,000 | 4.97% | ||
| 8 | ARMISTICE CAPITAL, LLC | 870,000 | 13,128,000 | 4.58% | ||
| 9 | Tourbillon Capital Partners, L.P. | 635,000 | 9,582,000 | 3.34% | ||
| 10 | VANGUARD GROUP INC | 576,523 | 8,700,000 | 3.03% | ||
| 11 | BAKER BROS. ADVISORS LP | 571,000 | 8,616,000 | 3.00% | ||
| 12 | Sio Capital Management, LLC | 522,756 | 7,888,000 | 2.75% | ||
| 13 | BlackRock Fund Advisors | 476,882 | 7,196,000 | 2.51% | ||
| 14 | Artal Group S.A. | 450,000 | 6,791,000 | 2.37% | ||
| 15 | LORD, ABBETT & CO. LLC | 307,760 | 4,644,000 | 1.62% | ||
| 16 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 267,697 | 4,039,000 | 1.41% | ||
| 17 | CITADEL ADVISORS LLC | 226,054 | 3,411,000 | 1.19% | ||
| 18 | Candriam S.C.A. | 210,000 | 3,169,000 | 1.10% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 208,649 | 3,149,000 | 1.10% | ||
| 20 | STATE STREET CORP | 165,269 | 2,496,000 | 0.87% | ||
| 21 | SABBY MANAGEMENT, LLC | 164,100 | 2,476,000 | 0.86% | ||
| 22 | Informed Momentum Co LLC | 160,874 | 2,428,000 | 0.85% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 159,700 | 2,410,000 | 0.84% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 155,253 | 2,342,000 | 0.82% | ||
| 25 | Iguana Healthcare Management, LLC | 150,000 | 2,264,000 | 0.79% | ||
| 26 | Spark Investment Management LLC | 142,700 | 2,153,000 | 0.75% | ||
| 27 | BLACKROCK ADVISORS LLC | 100,364 | 1,514,000 | 0.53% | ||
| 28 | BAILARD, INC. | 100,000 | 1,509,000 | 0.53% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 91,487 | 1,381,000 | 0.48% | ||
| 30 | Bank of New York Mellon Corp | 73,325 | 1,107,000 | 0.39% | ||
| 31 | BALYASNY ASSET MANAGEMENT L.P. | 70,000 | 1,056,000 | 0.37% | ||
| 32 | BlackRock Investment Management, LLC | 66,729 | 1,007,000 | 0.35% | ||
| 33 | CADIAN CAPITAL MANAGEMENT, LP | 60,000 | 905,000 | 0.32% | ||
| 34 | RUSSELL FRANK CO/ | 58,463 | 882,000 | 0.31% | ||
| 35 | NORTHERN TRUST CORP | 55,298 | 835,000 | 0.29% | ||
| 36 | Cubist Systematic Strategies, LLC | 52,380 | 790,000 | 0.28% | ||
| 37 | MONASHEE INVESTMENT MANAGEMENT LLC | 50,000 | 755,000 | 0.26% | PRN | |
| 38 | OXFORD ASSET MANAGEMENT LLP | 37,524 | 566,000 | 0.20% | ||
| 39 | TFS CAPITAL LLC | 37,257 | 562,000 | 0.20% | ||
| 40 | Belmont Global Advisors, Inc. | 35,000 | 528,000 | 0.18% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,516 | 506,000 | 0.18% | ||
| 42 | Nationwide Fund Advisors | 32,308 | 488,000 | 0.17% | ||
| 43 | ELLINGTON MANAGEMENT GROUP LLC | 28,000 | 423,000 | 0.15% | ||
| 44 | TEACHERS ADVISORS, LLC | 26,889 | 406,000 | 0.14% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,545 | 401,000 | 0.14% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 21,974 | 332,000 | 0.12% | ||
| 47 | RHUMBLINE ADVISERS | 18,140 | 274,000 | 0.10% | ||
| 48 | TWO SIGMA INVESTMENTS, LP | 17,585 | 265,000 | 0.09% | ||
| 49 | METROPOLITAN LIFE INSURANCE CO/NY | 13,958 | 211,000 | 0.07% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 13,700 | 207,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
