| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 2,256,546 | 15,277,000 | 11.81% | ||
| 2 | FMR LLC | 1,851,681 | 12,536,000 | 9.69% | ||
| 3 | RS INVESTMENT MANAGEMENT CO LLC | 1,693,999 | 11,468,000 | 8.86% | ||
| 4 | ARMISTICE CAPITAL, LLC | 1,688,000 | 11,428,000 | 8.83% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 1,347,060 | 9,119,000 | 7.05% | ||
| 6 | FRAZIER MANAGEMENT LLC | 950,366 | 6,434,000 | 4.97% | ||
| 7 | JPMORGAN CHASE & CO | 946,572 | 6,408,000 | 4.95% | ||
| 8 | Sio Capital Management, LLC | 805,327 | 5,452,000 | 4.21% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 770,133 | 5,214,000 | 4.03% | ||
| 10 | VANGUARD GROUP INC | 753,211 | 5,100,000 | 3.94% | ||
| 11 | Lombard Odier Asset Management (USA) Corp | 703,376 | 4,762,000 | 3.68% | ||
| 12 | BAKER BROS. ADVISORS LP | 571,000 | 3,866,000 | 2.99% | ||
| 13 | BlackRock Fund Advisors | 547,723 | 3,708,000 | 2.87% | ||
| 14 | Artal Group S.A. | 500,000 | 3,385,000 | 2.62% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 407,136 | 2,756,000 | 2.13% | ||
| 16 | STATE STREET CORP | 308,300 | 2,087,000 | 1.61% | ||
| 17 | GREAT POINT PARTNERS LLC | 287,173 | 1,944,000 | 1.50% | ||
| 18 | Candriam S.C.A. | 240,000 | 1,616,000 | 1.25% | ||
| 19 | NORTHERN TRUST CORP | 236,580 | 1,602,000 | 1.24% | ||
| 20 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 175,000 | 1,185,000 | 0.92% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 168,003 | 1,137,000 | 0.88% | ||
| 22 | NEXTHERA CAPITAL LP | 150,000 | 1,016,000 | 0.79% | ||
| 23 | Spark Investment Management LLC | 138,900 | 940,000 | 0.73% | ||
| 24 | SABBY MANAGEMENT, LLC | 125,000 | 846,000 | 0.65% | ||
| 25 | Iguana Healthcare Management, LLC | 125,000 | 846,000 | 0.65% | ||
| 26 | CASDIN CAPITAL, LLC | 110,000 | 745,000 | 0.58% | ||
| 27 | BLACKROCK ADVISORS LLC | 91,730 | 621,000 | 0.48% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 89,395 | 605,000 | 0.47% | ||
| 29 | Opus Point Partners Management, LLC | 81,000 | 548,000 | 0.42% | ||
| 30 | BlackRock Investment Management, LLC | 78,646 | 532,000 | 0.41% | ||
| 31 | JACOBS LEVY EQUITY MANAGEMENT, INC | 76,348 | 517,000 | 0.40% | ||
| 32 | Bank of New York Mellon Corp | 71,397 | 483,000 | 0.37% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 61,800 | 418,000 | 0.32% | ||
| 34 | DRW Securities, LLC | 54,806 | 371,000 | 0.29% | ||
| 35 | MORGAN STANLEY | 53,314 | 361,000 | 0.28% | ||
| 36 | TFS CAPITAL LLC | 52,532 | 356,000 | 0.28% | ||
| 37 | BVF INC/IL | 50,000 | 339,000 | 0.26% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 48,700 | 330,000 | 0.26% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,516 | 308,000 | 0.24% | ||
| 40 | TANG CAPITAL MANAGEMENT LLC | 40,000 | 271,000 | 0.21% | ||
| 41 | Trexquant Investment LP | 38,192 | 259,000 | 0.20% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,845 | 243,000 | 0.19% | ||
| 43 | TEACHERS ADVISORS, LLC | 33,164 | 225,000 | 0.17% | ||
| 44 | AQR CAPITAL MANAGEMENT LLC | 29,840 | 202,000 | 0.16% | ||
| 45 | Nationwide Fund Advisors | 27,350 | 185,000 | 0.14% | ||
| 46 | RHUMBLINE ADVISERS | 24,760 | 168,000 | 0.13% | ||
| 47 | VIRTUS ETF ADVISERS LLC | 21,317 | 144,000 | 0.11% | ||
| 48 | A.R.T. Advisors, LLC | 20,000 | 135,000 | 0.10% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 19,800 | 134,000 | 0.10% | ||
| 50 | DIMENSIONAL FUND ADVISORS LP | 15,462 | 105,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
