| 1 |
Broadfin Capital, LLC |
2,256,546 |
30,238,000 |
11.40% |
|
|
| 2 |
FMR LLC |
1,962,081 |
26,292,000 |
9.91% |
|
|
| 3 |
PERCEPTIVE ADVISORS LLC |
1,812,060 |
24,282,000 |
9.15% |
|
|
| 4 |
RS INVESTMENT MANAGEMENT CO LLC |
1,534,161 |
20,558,000 |
7.75% |
|
|
| 5 |
Lombard Odier Asset Management (USA) Corp |
1,341,158 |
17,972,000 |
6.77% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
1,124,798 |
15,072,000 |
5.68% |
|
|
| 7 |
JPMORGAN CHASE & CO |
1,025,629 |
13,744,000 |
5.18% |
|
|
| 8 |
ARMISTICE CAPITAL, LLC |
952,000 |
12,757,000 |
4.81% |
|
|
| 9 |
FRAZIER MANAGEMENT LLC |
950,366 |
12,735,000 |
4.80% |
|
|
| 10 |
VANGUARD GROUP INC |
736,224 |
9,865,000 |
3.72% |
|
|
| 11 |
Sio Capital Management, LLC |
644,617 |
8,638,000 |
3.26% |
|
|
| 12 |
Tourbillon Capital Partners, L.P. |
630,919 |
8,454,000 |
3.19% |
|
|
| 13 |
BAKER BROS. ADVISORS LP |
571,000 |
7,651,000 |
2.88% |
|
|
| 14 |
BlackRock Fund Advisors |
568,356 |
7,616,000 |
2.87% |
|
|
| 15 |
Artal Group S.A. |
475,000 |
6,365,000 |
2.40% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
408,816 |
5,478,000 |
2.06% |
|
|
| 17 |
EverPoint Asset Management, LLC |
380,000 |
5,092,000 |
1.92% |
|
|
| 18 |
STATE STREET CORP |
275,104 |
3,687,000 |
1.39% |
|
|
| 19 |
Candriam S.C.A. |
267,500 |
3,585,000 |
1.35% |
|
|
| 20 |
NORTHERN TRUST CORP |
234,222 |
3,139,000 |
1.18% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
164,496 |
2,204,000 |
0.83% |
|
|
| 22 |
Iguana Healthcare Management, LLC |
160,000 |
2,144,000 |
0.81% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
142,100 |
1,904,000 |
0.72% |
|
|
| 24 |
Opus Point Partners Management, LLC |
100,000 |
1,340,000 |
0.51% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
93,532 |
1,253,000 |
0.47% |
|
|
| 26 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
91,500 |
1,226,000 |
0.46% |
|
|
| 27 |
BLACKROCK ADVISORS LLC |
90,204 |
1,209,000 |
0.46% |
|
|
| 28 |
BlackRock Investment Management, LLC |
77,727 |
1,042,000 |
0.39% |
|
|
| 29 |
Bank of New York Mellon Corp |
69,767 |
935,000 |
0.35% |
|
|
| 30 |
AQR CAPITAL MANAGEMENT LLC |
57,523 |
771,000 |
0.29% |
|
|
| 31 |
SABBY MANAGEMENT, LLC |
54,099 |
725,000 |
0.27% |
|
|
| 32 |
MORGAN STANLEY |
51,117 |
684,000 |
0.26% |
|
|
| 33 |
Trexquant Investment LP |
42,100 |
564,000 |
0.21% |
|
|
| 34 |
OXFORD ASSET MANAGEMENT LLP |
40,784 |
547,000 |
0.21% |
|
|
| 35 |
DRW Securities, LLC |
40,000 |
536,000 |
0.20% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
39,746 |
533,000 |
0.20% |
|
|
| 37 |
Point72 Asset Management, L.P. |
39,500 |
529,000 |
0.20% |
|
|
| 38 |
Spark Investment Management LLC |
37,000 |
495,000 |
0.19% |
|
|
| 39 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
35,845 |
481,000 |
0.18% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
30,147 |
404,000 |
0.15% |
|
|
| 41 |
RHUMBLINE ADVISERS |
23,315 |
312,000 |
0.12% |
|
|
| 42 |
VIRTUS ETF ADVISERS LLC |
22,638 |
303,000 |
0.11% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
19,800 |
265,000 |
0.10% |
|
|
| 44 |
DIMENSIONAL FUND ADVISORS LP |
15,462 |
207,000 |
0.08% |
|
|
| 45 |
METROPOLITAN LIFE INSURANCE CO/NY |
13,958 |
187,000 |
0.07% |
|
|
| 46 |
Nationwide Fund Advisors |
13,750 |
184,000 |
0.07% |
|
|
| 47 |
PILLAR PACIFIC CAPITAL MANAGEMENT LLC |
13,500 |
181,000 |
0.07% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
13,115 |
176,000 |
0.07% |
|
|
| 49 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,747 |
144,000 |
0.05% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
10,538 |
141,000 |
0.05% |
|
|
