| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 3,972,800 | 24,989,000 | 15.43% | ||
| 2 | GREAT POINT PARTNERS LLC | 3,475,227 | 21,859,000 | 13.49% | ||
| 3 | VICTORY CAPITAL MANAGEMENT INC | 2,370,473 | 14,911,000 | 9.21% | ||
| 4 | Broadfin Capital, LLC | 2,256,546 | 14,194,000 | 8.76% | ||
| 5 | ARMISTICE CAPITAL, LLC | 1,464,000 | 9,209,000 | 5.69% | ||
| 6 | VANGUARD GROUP INC | 1,050,293 | 6,606,000 | 4.08% | ||
| 7 | FRAZIER MANAGEMENT LLC | 950,366 | 5,978,000 | 3.69% | ||
| 8 | JPMORGAN CHASE & CO | 910,604 | 5,727,000 | 3.54% | ||
| 9 | Artal Group S.A. | 850,000 | 5,347,000 | 3.30% | ||
| 10 | BlackRock Fund Advisors | 825,798 | 5,194,000 | 3.21% | ||
| 11 | Lombard Odier Asset Management (USA) Corp | 778,440 | 4,896,000 | 3.02% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 675,000 | 4,246,000 | 2.62% | ||
| 13 | FMR LLC | 670,331 | 4,216,000 | 2.60% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 615,823 | 3,874,000 | 2.39% | ||
| 15 | BAKER BROS. ADVISORS LP | 571,000 | 3,592,000 | 2.22% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 525,797 | 3,307,000 | 2.04% | ||
| 17 | STATE STREET CORP | 396,028 | 2,490,000 | 1.54% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 339,727 | 2,137,000 | 1.32% | ||
| 19 | NORTHERN TRUST CORP | 326,589 | 2,054,000 | 1.27% | ||
| 20 | Spark Investment Management LLC | 236,200 | 1,485,000 | 0.92% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 226,446 | 1,424,000 | 0.88% | ||
| 22 | SABBY MANAGEMENT, LLC | 225,900 | 1,421,000 | 0.88% | ||
| 23 | EverPoint Asset Management, LLC | 225,000 | 1,415,000 | 0.87% | ||
| 24 | CASDIN CAPITAL, LLC | 195,000 | 1,227,000 | 0.76% | ||
| 25 | SECOR Capital Advisors, LP | 161,031 | 1,013,000 | 0.63% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 144,031 | 906,000 | 0.56% | ||
| 27 | BlackRock Investment Management, LLC | 115,716 | 728,000 | 0.45% | ||
| 28 | BLACKROCK ADVISORS LLC | 97,346 | 612,000 | 0.38% | ||
| 29 | Bank of New York Mellon Corp | 93,634 | 589,000 | 0.36% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 89,900 | 565,000 | 0.35% | ||
| 31 | DEUTSCHE BANK AG\ | 66,851 | 419,000 | 0.26% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,411 | 393,000 | 0.24% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 61,800 | 389,000 | 0.24% | ||
| 34 | MORGAN STANLEY | 57,788 | 364,000 | 0.22% | ||
| 35 | TEACHERS ADVISORS, LLC | 54,496 | 343,000 | 0.21% | ||
| 36 | Endurant Capital Management LP | 52,200 | 328,000 | 0.20% | ||
| 37 | JACOBS LEVY EQUITY MANAGEMENT, INC | 47,048 | 296,000 | 0.18% | ||
| 38 | VIRTUS ETF ADVISERS LLC | 44,599 | 281,000 | 0.17% | ||
| 39 | D. E. Shaw & Co., Inc. | 40,165 | 253,000 | 0.16% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,845 | 226,000 | 0.14% | ||
| 41 | GOLDMAN SACHS GROUP INC | 30,493 | 192,000 | 0.12% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 29,006 | 182,000 | 0.11% | ||
| 43 | RHUMBLINE ADVISERS | 28,045 | 176,000 | 0.11% | ||
| 44 | Mirae Asset Global Investments Co., Ltd. | 27,400 | 172,000 | 0.11% | ||
| 45 | CREDIT SUISSE AG/ | 26,266 | 166,000 | 0.10% | ||
| 46 | TFS CAPITAL LLC | 22,755 | 143,000 | 0.09% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,512 | 135,000 | 0.08% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 19,800 | 125,000 | 0.08% | ||
| 49 | AQR CAPITAL MANAGEMENT LLC | 19,886 | 125,000 | 0.08% | ||
| 50 | Numeric Investors LLC | 19,568 | 123,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
