| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 2,256,546 | 19,812,000 | 12.32% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 1,931,600 | 16,959,000 | 10.55% | ||
| 3 | FMR LLC | 1,930,109 | 16,946,000 | 10.54% | ||
| 4 | Lombard Odier Asset Management (USA) Corp | 1,419,043 | 12,459,000 | 7.75% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,413,430 | 12,410,000 | 7.72% | ||
| 6 | RS INVESTMENT MANAGEMENT CO LLC | 1,197,850 | 10,517,000 | 6.54% | ||
| 7 | JPMORGAN CHASE & CO | 1,009,218 | 8,861,000 | 5.51% | ||
| 8 | ARMISTICE CAPITAL, LLC | 934,000 | 8,201,000 | 5.10% | ||
| 9 | VANGUARD GROUP INC | 731,056 | 6,418,000 | 3.99% | ||
| 10 | Sio Capital Management, LLC | 682,306 | 5,991,000 | 3.73% | ||
| 11 | Tourbillon Capital Partners, L.P. | 629,337 | 5,526,000 | 3.44% | ||
| 12 | BAKER BROS. ADVISORS LP | 571,000 | 5,013,000 | 3.12% | ||
| 13 | BlackRock Fund Advisors | 555,002 | 4,873,000 | 3.03% | ||
| 14 | Artal Group S.A. | 475,000 | 4,171,000 | 2.59% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 362,008 | 3,178,000 | 1.98% | ||
| 16 | SABBY MANAGEMENT, LLC | 252,974 | 2,221,000 | 1.38% | ||
| 17 | STATE STREET CORP | 242,781 | 2,131,000 | 1.33% | ||
| 18 | NORTHERN TRUST CORP | 234,400 | 2,058,000 | 1.28% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 215,800 | 1,895,000 | 1.18% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 165,485 | 1,452,000 | 0.90% | ||
| 21 | Iguana Healthcare Management, LLC | 125,000 | 1,098,000 | 0.68% | ||
| 22 | LORD, ABBETT & CO. LLC | 102,052 | 896,000 | 0.56% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 98,008 | 861,000 | 0.54% | ||
| 24 | BLACKROCK ADVISORS LLC | 95,383 | 837,000 | 0.52% | ||
| 25 | Spark Investment Management LLC | 91,600 | 803,000 | 0.50% | ||
| 26 | BlackRock Investment Management, LLC | 77,090 | 677,000 | 0.42% | ||
| 27 | Bank of New York Mellon Corp | 67,464 | 593,000 | 0.37% | ||
| 28 | Trexquant Investment LP | 54,035 | 474,000 | 0.29% | ||
| 29 | AQR CAPITAL MANAGEMENT LLC | 51,607 | 453,000 | 0.28% | ||
| 30 | DEUTSCHE BANK AG\ | 50,326 | 440,000 | 0.27% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,116 | 343,000 | 0.21% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,845 | 315,000 | 0.20% | ||
| 33 | CITADEL ADVISORS LLC | 29,045 | 255,000 | 0.16% | ||
| 34 | TEACHERS ADVISORS, LLC | 26,889 | 236,000 | 0.15% | ||
| 35 | RHUMBLINE ADVISERS | 20,690 | 182,000 | 0.11% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 19,800 | 174,000 | 0.11% | ||
| 37 | MORGAN STANLEY | 17,993 | 158,000 | 0.10% | ||
| 38 | METROPOLITAN LIFE INSURANCE CO/NY | 13,958 | 123,000 | 0.08% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 13,700 | 120,000 | 0.07% | ||
| 40 | PILLAR PACIFIC CAPITAL MANAGEMENT LLC | 13,500 | 118,000 | 0.07% | ||
| 41 | Nationwide Fund Advisors | 13,266 | 116,000 | 0.07% | ||
| 42 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,115 | 115,000 | 0.07% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 10,766 | 95,000 | 0.06% | ||
| 44 | TFS CAPITAL LLC | 10,771 | 95,000 | 0.06% | ||
| 45 | BNP PARIBAS FINANCIAL MARKETS | 5,012 | 44,005 | 0.03% | ||
| 46 | WELLS FARGO & COMPANY/MN | 4,077 | 36,000 | 0.02% | ||
| 47 | PANAGORA ASSET MANAGEMENT INC | 3,904 | 34,000 | 0.02% | ||
| 48 | Walleye Trading LLC | 1,500 | 13,000 | 0.01% | ||
| 49 | BlackRock Japan Co. Ltd | 1,134 | 10,000 | 0.01% | ||
| 50 | ROYAL BANK OF CANADA | 1,031 | 9,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
