| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 4,000,000 | 21,200,000 | 15.53% | ||
| 2 | TANG CAPITAL MANAGEMENT LLC | 3,972,800 | 21,056,000 | 15.42% | ||
| 3 | VICTORY CAPITAL MANAGEMENT INC | 2,414,093 | 12,794,000 | 9.37% | ||
| 4 | Broadfin Capital, LLC | 2,256,546 | 11,960,000 | 8.76% | ||
| 5 | ARMISTICE CAPITAL, LLC | 2,000,000 | 10,600,000 | 7.76% | ||
| 6 | VANGUARD GROUP INC | 1,112,965 | 5,899,000 | 4.32% | ||
| 7 | FRAZIER MANAGEMENT LLC | 950,366 | 5,037,000 | 3.69% | ||
| 8 | BlackRock Fund Advisors | 948,441 | 5,027,000 | 3.68% | ||
| 9 | JPMORGAN CHASE & CO | 922,638 | 4,890,000 | 3.58% | ||
| 10 | Artal Group S.A. | 850,000 | 4,505,000 | 3.30% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 773,977 | 4,102,000 | 3.00% | ||
| 12 | BAKER BROS. ADVISORS LP | 571,000 | 3,026,000 | 2.22% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 557,183 | 2,953,000 | 2.16% | ||
| 14 | FMR LLC | 524,331 | 2,779,000 | 2.04% | ||
| 15 | Lombard Odier Asset Management (USA) Corp | 500,000 | 2,650,000 | 1.94% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 472,686 | 2,505,000 | 1.83% | ||
| 17 | STATE STREET CORP | 426,861 | 2,264,000 | 1.66% | ||
| 18 | NORTHERN TRUST CORP | 326,769 | 1,731,000 | 1.27% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 231,144 | 1,225,000 | 0.90% | ||
| 20 | SABBY MANAGEMENT, LLC | 195,000 | 1,034,000 | 0.76% | ||
| 21 | BOXER CAPITAL, LLC | 125,000 | 663,000 | 0.49% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 124,728 | 661,000 | 0.48% | ||
| 23 | MORGAN STANLEY | 117,115 | 621,000 | 0.45% | ||
| 24 | BlackRock Investment Management, LLC | 116,536 | 618,000 | 0.45% | ||
| 25 | Bank of New York Mellon Corp | 115,454 | 612,000 | 0.45% | ||
| 26 | BLACKROCK ADVISORS LLC | 97,613 | 517,000 | 0.38% | ||
| 27 | SECOR Capital Advisors, LP | 93,418 | 495,000 | 0.36% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 92,100 | 488,000 | 0.36% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 61,800 | 328,000 | 0.24% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,711 | 322,000 | 0.24% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 57,745 | 307,000 | 0.22% | ||
| 32 | DIMENSIONAL FUND ADVISORS LP | 57,168 | 303,000 | 0.22% | ||
| 33 | D. E. Shaw & Co., Inc. | 56,436 | 299,000 | 0.22% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,021 | 297,000 | 0.22% | ||
| 35 | TEACHERS ADVISORS, LLC | 54,496 | 289,000 | 0.21% | ||
| 36 | JACOBS LEVY EQUITY MANAGEMENT, INC | 43,548 | 231,000 | 0.17% | ||
| 37 | DEUTSCHE BANK AG\ | 31,642 | 166,000 | 0.12% | ||
| 38 | TFS CAPITAL LLC | 30,806 | 163,000 | 0.12% | ||
| 39 | RHUMBLINE ADVISERS | 28,874 | 153,000 | 0.11% | ||
| 40 | Endurant Capital Management LP | 26,012 | 138,000 | 0.10% | ||
| 41 | Nationwide Fund Advisors | 23,771 | 126,000 | 0.09% | ||
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 22,065 | 117,000 | 0.09% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,116 | 117,000 | 0.09% | ||
| 44 | TEZA CAPITAL MANAGEMENT LLC | 21,163 | 112,000 | 0.08% | ||
| 45 | WELLS FARGO & COMPANY/MN | 20,885 | 111,000 | 0.08% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 20,800 | 110,000 | 0.08% | ||
| 47 | AQR CAPITAL MANAGEMENT LLC | 19,886 | 105,000 | 0.08% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 19,800 | 105,000 | 0.08% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 16,951 | 90,000 | 0.07% | ||
| 50 | CREDIT SUISSE AG/ | 15,238 | 81,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
