| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 3,972,800 | 21,533,000 | 15.29% | ||
| 2 | GREAT POINT PARTNERS LLC | 3,238,703 | 17,554,000 | 12.46% | ||
| 3 | Broadfin Capital, LLC | 2,256,546 | 12,230,000 | 8.68% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 2,032,793 | 11,018,000 | 7.82% | ||
| 5 | ARMISTICE CAPITAL, LLC | 1,556,000 | 8,434,000 | 5.99% | ||
| 6 | FMR LLC | 1,378,131 | 7,469,000 | 5.30% | ||
| 7 | VANGUARD GROUP INC | 955,541 | 5,179,000 | 3.68% | ||
| 8 | FRAZIER MANAGEMENT LLC | 950,366 | 5,151,000 | 3.66% | ||
| 9 | JPMORGAN CHASE & CO | 923,523 | 5,006,000 | 3.55% | ||
| 10 | Lombard Odier Asset Management (USA) Corp | 811,016 | 4,396,000 | 3.12% | ||
| 11 | BlackRock Fund Advisors | 758,468 | 4,111,000 | 2.92% | ||
| 12 | Artal Group S.A. | 750,000 | 4,065,000 | 2.89% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 675,000 | 3,659,000 | 2.60% | ||
| 14 | BAKER BROS. ADVISORS LP | 571,000 | 3,095,000 | 2.20% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 521,104 | 2,824,000 | 2.00% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 435,260 | 2,359,000 | 1.67% | ||
| 17 | CASDIN CAPITAL, LLC | 375,000 | 2,033,000 | 1.44% | ||
| 18 | NORTHERN TRUST CORP | 341,717 | 1,853,000 | 1.32% | ||
| 19 | STATE STREET CORP | 316,427 | 1,714,000 | 1.22% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 314,412 | 1,704,000 | 1.21% | ||
| 21 | NEXTHERA CAPITAL LP | 235,000 | 1,274,000 | 0.90% | ||
| 22 | ACUTA CAPITAL PARTNERS, LLC | 229,748 | 1,245,000 | 0.88% | ||
| 23 | SABBY MANAGEMENT, LLC | 225,000 | 1,220,000 | 0.87% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 214,498 | 1,162,000 | 0.82% | ||
| 25 | Spark Investment Management LLC | 211,000 | 1,143,000 | 0.81% | ||
| 26 | SECOR Capital Advisors, LP | 193,603 | 1,050,000 | 0.75% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 127,641 | 692,000 | 0.49% | ||
| 28 | BlackRock Investment Management, LLC | 115,676 | 627,000 | 0.45% | ||
| 29 | Trexquant Investment LP | 100,774 | 546,000 | 0.39% | ||
| 30 | Bank of New York Mellon Corp | 100,078 | 543,000 | 0.39% | ||
| 31 | Belmont Global Advisors, Inc. | 100,000 | 542,000 | 0.38% | ||
| 32 | BLACKROCK ADVISORS LLC | 93,702 | 508,000 | 0.36% | ||
| 33 | A.R.T. Advisors, LLC | 81,888 | 443,000 | 0.31% | ||
| 34 | MORGAN STANLEY | 70,484 | 382,000 | 0.27% | ||
| 35 | TFS CAPITAL LLC | 65,576 | 355,000 | 0.25% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,811 | 335,000 | 0.24% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 61,800 | 335,000 | 0.24% | ||
| 38 | JACOBS LEVY EQUITY MANAGEMENT, INC | 56,748 | 308,000 | 0.22% | ||
| 39 | TEACHERS ADVISORS, LLC | 49,287 | 267,000 | 0.19% | ||
| 40 | VIRTUS ETF ADVISERS LLC | 44,599 | 242,000 | 0.17% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,845 | 195,000 | 0.14% | ||
| 42 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 36,000 | 195,000 | 0.14% | ||
| 43 | Nationwide Fund Advisors | 32,394 | 176,000 | 0.12% | ||
| 44 | AQR CAPITAL MANAGEMENT LLC | 29,840 | 162,000 | 0.12% | ||
| 45 | RHUMBLINE ADVISERS | 27,635 | 150,000 | 0.11% | ||
| 46 | CREDIT SUISSE AG/ | 25,096 | 136,000 | 0.10% | ||
| 47 | D. E. Shaw & Co., Inc. | 24,867 | 135,000 | 0.10% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,154 | 120,000 | 0.09% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 20,300 | 110,000 | 0.08% | ||
| 50 | Endurant Capital Management LP | 20,200 | 109,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
