| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 3,972,800 | 34,166,000 | 14.85% | ||
| 2 | GREAT POINT PARTNERS LLC | 3,071,300 | 26,413,000 | 11.48% | ||
| 3 | VICTORY CAPITAL MANAGEMENT INC | 2,804,834 | 24,122,000 | 10.49% | ||
| 4 | Broadfin Capital, LLC | 2,637,346 | 22,681,000 | 9.86% | ||
| 5 | BlackRock Finance, Inc. | 1,667,808 | 14,342,000 | 6.23% | ||
| 6 | ARMISTICE CAPITAL, LLC | 1,486,000 | 12,780,000 | 5.56% | ||
| 7 | VANGUARD GROUP INC | 1,228,177 | 10,562,000 | 4.59% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 1,025,291 | 8,818,000 | 3.83% | ||
| 9 | FRAZIER MANAGEMENT LLC | 973,693 | 8,374,000 | 3.64% | ||
| 10 | Artal Group S.A. | 937,000 | 8,058,000 | 3.50% | ||
| 11 | JPMORGAN CHASE & CO | 935,542 | 8,046,000 | 3.50% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 794,833 | 6,836,000 | 2.97% | ||
| 13 | PointState Capital LP | 706,200 | 6,073,000 | 2.64% | ||
| 14 | BAKER BROS. ADVISORS LP | 571,000 | 4,911,000 | 2.13% | ||
| 15 | FMR LLC | 492,031 | 4,231,000 | 1.84% | ||
| 16 | STATE STREET CORP | 439,926 | 3,785,000 | 1.65% | ||
| 17 | Lombard Odier Asset Management (USA) Corp | 400,000 | 3,440,000 | 1.50% | ||
| 18 | NEXTHERA CAPITAL LP | 335,000 | 2,881,000 | 1.25% | ||
| 19 | NORTHERN TRUST CORP | 327,367 | 2,815,000 | 1.22% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 241,615 | 2,077,000 | 0.90% | ||
| 21 | Informed Momentum Co LLC | 151,963 | 1,307,000 | 0.57% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,339 | 1,104,000 | 0.48% | ||
| 23 | MORGAN STANLEY | 116,010 | 998,000 | 0.43% | ||
| 24 | Bank of New York Mellon Corp | 110,593 | 951,000 | 0.41% | ||
| 25 | SABBY MANAGEMENT, LLC | 95,918 | 825,000 | 0.36% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91,645 | 789,000 | 0.34% | ||
| 27 | D. E. Shaw & Co., Inc. | 91,202 | 784,000 | 0.34% | ||
| 28 | J. Goldman & Co LP | 80,000 | 688,000 | 0.30% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 61,800 | 531,000 | 0.23% | ||
| 30 | DIMENSIONAL FUND ADVISORS LP | 61,114 | 526,000 | 0.23% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,011 | 499,000 | 0.22% | ||
| 32 | TEACHERS ADVISORS, LLC | 57,244 | 492,000 | 0.21% | ||
| 33 | Telemetry Investments, L.L.C. | 53,489 | 460,000 | 0.20% | ||
| 34 | DEUTSCHE BANK AG\ | 47,824 | 411,000 | 0.18% | ||
| 35 | Neuberger Berman Group LLC | 42,500 | 366,000 | 0.16% | ||
| 36 | CITADEL ADVISORS LLC | 36,766 | 316,000 | 0.14% | ||
| 37 | TFS CAPITAL LLC | 32,486 | 279,000 | 0.12% | ||
| 38 | RHUMBLINE ADVISERS | 32,221 | 277,000 | 0.12% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 26,845 | 231,000 | 0.10% | ||
| 40 | JACOBS LEVY EQUITY MANAGEMENT, INC | 25,548 | 220,000 | 0.10% | ||
| 41 | Trexquant Investment LP | 25,495 | 219,000 | 0.10% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 24,401 | 210,000 | 0.09% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,982 | 206,000 | 0.09% | ||
| 44 | METROPOLITAN LIFE INSURANCE CO/NY | 23,356 | 201,000 | 0.09% | ||
| 45 | WELLS FARGO & COMPANY/MN | 21,885 | 188,000 | 0.08% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 20,800 | 179,000 | 0.08% | ||
| 47 | AMERICAN INTERNATIONAL GROUP, INC. | 18,148 | 156,000 | 0.07% | ||
| 48 | Squarepoint Ops LLC | 17,070 | 147,000 | 0.06% | ||
| 49 | Nationwide Fund Advisors | 16,581 | 143,000 | 0.06% | ||
| 50 | RENAISSANCE TECHNOLOGIES LLC | 16,580 | 143,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
