| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 5,419,449 | 122,263,000 | 55.61% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 527,337 | 11,897,000 | 5.41% | ||
| 3 | Redmile Group, LLC | 450,500 | 10,163,000 | 4.62% | ||
| 4 | FMR LLC | 400,000 | 9,024,000 | 4.10% | ||
| 5 | BLACKROCK ADVISORS LLC | 338,870 | 7,645,000 | 3.48% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 281,200 | 6,344,000 | 2.89% | ||
| 7 | EMERALD ADVISERS, LLC | 268,970 | 6,068,000 | 2.76% | ||
| 8 | EMERALD MUTUAL FUND ADVISERS TRUST | 268,282 | 6,052,000 | 2.75% | ||
| 9 | BlackRock Group LTD | 178,941 | 4,037,000 | 1.84% | ||
| 10 | KORNITZER CAPITAL MANAGEMENT INC /KS | 172,900 | 3,901,000 | 1.77% | ||
| 11 | JPMORGAN CHASE & CO | 142,510 | 3,215,000 | 1.46% | ||
| 12 | BlackRock Fund Advisors | 128,477 | 2,898,000 | 1.32% | ||
| 13 | Allianz Asset Management GmbH | 121,700 | 2,746,000 | 1.25% | ||
| 14 | ROYCE & ASSOCIATES LP | 112,755 | 2,544,000 | 1.16% | ||
| 15 | Alyeska Investment Group, L.P. | 112,606 | 2,540,000 | 1.16% | ||
| 16 | VANGUARD GROUP INC | 77,802 | 1,755,000 | 0.80% | ||
| 17 | DEUTSCHE BANK AG\ | 70,659 | 1,592,000 | 0.72% | ||
| 18 | CADENCE CAPITAL MANAGEMENT LLC | 68,350 | 1,542,000 | 0.70% | ||
| 19 | STATE STREET CORP | 67,599 | 1,526,000 | 0.69% | ||
| 20 | BlackRock Investment Management, LLC | 65,645 | 1,481,000 | 0.67% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 63,228 | 1,426,000 | 0.65% | ||
| 22 | BLAIR WILLIAM & CO/IL | 62,682 | 1,414,000 | 0.64% | ||
| 23 | NORTHERN TRUST CORP | 51,603 | 1,165,000 | 0.53% | ||
| 24 | Columbia Asset Management | 41,800 | 943,000 | 0.43% | ||
| 25 | EDMUNDS WHITE PARTNERS LLC | 35,715 | 806,000 | 0.37% | SH | |
| 26 | BAMCO INC /NY/ | 32,400 | 731,000 | 0.33% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 25,000 | 564,000 | 0.26% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 19,624 | 443,000 | 0.20% | ||
| 29 | Bank of New York Mellon Corp | 18,154 | 410,000 | 0.19% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 18,058 | 407,000 | 0.19% | ||
| 31 | CITIGROUP INC | 16,380 | 370,000 | 0.17% | ||
| 32 | GOLDMAN SACHS GROUP INC | 13,216 | 298,000 | 0.14% | ||
| 33 | OPPENHEIMER & CO INC | 13,000 | 293,000 | 0.13% | ||
| 34 | TEACHERS ADVISORS, LLC | 12,389 | 279,000 | 0.13% | ||
| 35 | GSA CAPITAL PARTNERS LLP | 10,900 | 246,000 | 0.11% | ||
| 36 | BANQUE PICTET & CIE SA | 9,961 | 225,000 | 0.10% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,300 | 210,000 | 0.10% | ||
| 38 | Nationwide Fund Advisors | 3,901 | 88,000 | 0.04% | ||
| 39 | BARCLAYS PLC | 3,929 | 87,000 | 0.04% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 3,345 | 75,463 | 0.03% | ||
| 41 | MORGAN STANLEY | 2,236 | 51,000 | 0.02% | ||
| 42 | ROYAL BANK OF CANADA | 1,000 | 23,000 | 0.01% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 1,000 | 23,000 | 0.01% | ||
| 44 | WELLS FARGO & COMPANY/MN | 764 | 17,000 | 0.01% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 589 | 13,000 | 0.01% | ||
| 46 | VIRTUS CAPITAL ADVISERS, LLC | 436 | 10,000 | 0.00% | ||
| 47 | FIFTH THIRD BANCORP | 250 | 6,000 | 0.00% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 262 | 5,911 | 0.00% | ||
| 49 | Apriem Advisors | 153 | 3,000 | 0.00% | ||
| 50 | BANK OF MONTREAL /CAN/ | 130 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
