| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,549,320 | 158,300,000 | 20.18% | ||
| 2 | TimesSquare Capital Management, LLC | 1,159,700 | 51,723,000 | 6.59% | ||
| 3 | BLAIR WILLIAM & CO/IL | 724,084 | 32,294,000 | 4.12% | ||
| 4 | Allianz Asset Management GmbH | 685,348 | 30,567,000 | 3.90% | ||
| 5 | FMR LLC | 613,200 | 27,349,000 | 3.49% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 601,772 | 26,839,000 | 3.42% | ||
| 7 | NINE TEN CAPITAL MANAGEMENT LLC | 539,323 | 24,054,000 | 3.07% | ||
| 8 | LOOMIS SAYLES & CO L P | 504,179 | 22,487,000 | 2.87% | ||
| 9 | VANGUARD GROUP INC | 460,134 | 20,522,000 | 2.62% | ||
| 10 | Cortina Asset Management, LLC | 430,952 | 19,220,000 | 2.45% | ||
| 11 | BlackRock Fund Advisors | 414,070 | 18,468,000 | 2.35% | ||
| 12 | COLUMBUS CIRCLE INVESTORS | 393,929 | 17,569,000 | 2.24% | ||
| 13 | OppenheimerFunds, Inc. | 387,220 | 17,270,000 | 2.20% | ||
| 14 | ROYCE & ASSOCIATES LP | 316,755 | 14,127,000 | 1.80% | ||
| 15 | WELLS FARGO & COMPANY/MN | 307,882 | 13,732,000 | 1.75% | ||
| 16 | KALMAR INVESTMENTS INC /DE/ | 283,250 | 12,633,000 | 1.61% | ||
| 17 | KORNITZER CAPITAL MANAGEMENT INC /KS | 280,431 | 12,507,000 | 1.59% | ||
| 18 | THORNBURG INVESTMENT MANAGEMENT INC | 262,813 | 11,721,000 | 1.49% | ||
| 19 | CASTLEARK MANAGEMENT LLC | 260,834 | 11,633,000 | 1.48% | ||
| 20 | EMERALD ADVISERS, LLC | 256,070 | 11,421,000 | 1.46% | ||
| 21 | JPMORGAN CHASE & CO | 254,175 | 11,336,000 | 1.45% | ||
| 22 | NEXT CENTURY GROWTH INVESTORS LLC | 253,821 | 11,320,000 | 1.44% | ||
| 23 | Nichols Asset Management LLC | 251,832 | 11,232,000 | 1.43% | ||
| 24 | MORGAN STANLEY | 248,756 | 11,094,000 | 1.41% | ||
| 25 | LORD, ABBETT & CO. LLC | 234,634 | 10,465,000 | 1.33% | ||
| 26 | ROCKEFELLER FINANCIAL SERVICES INC | 230,453 | 10,278,000 | 1.31% | ||
| 27 | EMERALD MUTUAL FUND ADVISERS TRUST | 226,912 | 10,120,000 | 1.29% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 225,500 | 10,057,000 | 1.28% | ||
| 29 | STATE STREET CORP | 204,661 | 9,127,000 | 1.16% | ||
| 30 | BlackRock Institutional Trust Company, N.A. | 195,591 | 8,723,000 | 1.11% | ||
| 31 | MCKINLEY CAPITAL MANAGEMENT LLC | 172,402 | 7,689,000 | 0.98% | ||
| 32 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 157,501 | 7,025,000 | 0.90% | ||
| 33 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 122,596 | 5,467,000 | 0.70% | ||
| 34 | Timpani Capital Management LLC | 119,417 | 5,326,000 | 0.68% | ||
| 35 | THRIVENT FINANCIAL FOR LUTHERANS | 117,500 | 5,240,000 | 0.67% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 108,358 | 4,832,000 | 0.62% | ||
| 37 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 102,700 | 4,580,000 | 0.58% | ||
| 38 | NORTHERN TRUST CORP | 97,404 | 4,344,000 | 0.55% | ||
| 39 | Bank of New York Mellon Corp | 83,828 | 3,739,000 | 0.48% | ||
| 40 | ARBOR CAPITAL MANAGEMENT LLC | 77,400 | 3,452,000 | 0.44% | ||
| 41 | Tamarack Capital Management, LLC | 75,000 | 3,345,000 | 0.43% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 72,071 | 3,214,000 | 0.41% | ||
| 43 | Nuveen Asset Management, LLC | 68,387 | 3,050,000 | 0.39% | ||
| 44 | RUSSELL FRANK CO/ | 62,949 | 2,807,000 | 0.36% | ||
| 45 | BlackRock Investment Management, LLC | 55,972 | 2,496,000 | 0.32% | ||
| 46 | PRICE T ROWE ASSOCIATES INC /MD/ | 52,223 | 2,329,000 | 0.30% | ||
| 47 | TURNER INVESTMENTS LLC | 47,540 | 2,120,000 | 0.27% | ||
| 48 | PDT Partners, LLC | 42,665 | 1,903,000 | 0.24% | ||
| 49 | GSA CAPITAL PARTNERS LLP | 41,111 | 1,834,000 | 0.23% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 41,100 | 1,833,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
