| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,549,320 | 111,342,000 | 25.40% | ||
| 2 | Tamarack Capital Management, LLC | 674,000 | 21,143,000 | 4.82% | ||
| 3 | Cortina Asset Management, LLC | 592,081 | 18,574,000 | 4.24% | ||
| 4 | BLAIR WILLIAM & CO/IL | 515,522 | 16,171,000 | 3.69% | ||
| 5 | ROYCE & ASSOCIATES LP | 407,155 | 12,772,000 | 2.91% | ||
| 6 | FMR LLC | 400,000 | 12,548,000 | 2.86% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 384,385 | 12,058,000 | 2.75% | ||
| 8 | EMERALD ADVISERS, LLC | 362,028 | 11,357,000 | 2.59% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 354,330 | 11,115,000 | 2.54% | ||
| 10 | BLACKROCK ADVISORS LLC | 340,622 | 10,685,000 | 2.44% | ||
| 11 | EMERALD MUTUAL FUND ADVISERS TRUST | 326,452 | 10,241,000 | 2.34% | ||
| 12 | COLUMBUS CIRCLE INVESTORS | 296,184 | 9,291,000 | 2.12% | ||
| 13 | Nine Ten Partners LP | 281,621 | 8,834,000 | 2.02% | ||
| 14 | Allianz Asset Management GmbH | 272,217 | 8,539,000 | 1.95% | ||
| 15 | JPMORGAN CHASE & CO | 263,019 | 8,251,000 | 1.88% | ||
| 16 | TimesSquare Capital Management, LLC | 260,000 | 8,156,000 | 1.86% | ||
| 17 | Nichols Asset Management LLC | 235,236 | 7,379,000 | 1.68% | ||
| 18 | Pier Capital, LLC | 224,227 | 7,034,000 | 1.60% | ||
| 19 | WELLS FARGO & COMPANY/MN | 211,467 | 6,634,000 | 1.51% | ||
| 20 | SECTORAL ASSET MANAGEMENT INC | 206,734 | 6,485,000 | 1.48% | ||
| 21 | KORNITZER CAPITAL MANAGEMENT INC /KS | 206,036 | 6,463,000 | 1.47% | ||
| 22 | LORD, ABBETT & CO. LLC | 201,721 | 6,328,000 | 1.44% | ||
| 23 | VANGUARD GROUP INC | 199,027 | 6,244,000 | 1.42% | ||
| 24 | MCKINLEY CAPITAL MANAGEMENT LLC | 192,546 | 6,040,000 | 1.38% | ||
| 25 | MORGAN STANLEY | 184,715 | 5,795,000 | 1.32% | ||
| 26 | CASTLEARK MANAGEMENT LLC | 170,154 | 5,338,000 | 1.22% | ||
| 27 | BlackRock Group LTD | 162,609 | 5,101,000 | 1.16% | ||
| 28 | Versant Venture Management, LLC | 155,284 | 4,967,535 | 1.13% | ||
| 29 | ROCKEFELLER FINANCIAL SERVICES INC | 146,300 | 4,589,000 | 1.05% | ||
| 30 | BlackRock Fund Advisors | 144,577 | 4,535,000 | 1.03% | ||
| 31 | NEXT CENTURY GROWTH INVESTORS LLC | 143,818 | 4,511,000 | 1.03% | ||
| 32 | Nuveen Asset Management, LLC | 108,026 | 3,389,000 | 0.77% | ||
| 33 | ARBOR CAPITAL MANAGEMENT LLC | 106,230 | 3,332,000 | 0.76% | ||
| 34 | Alyeska Investment Group, L.P. | 103,506 | 3,247,000 | 0.74% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 96,105 | 3,015,000 | 0.69% | ||
| 36 | Timpani Capital Management LLC | 91,497 | 2,870,000 | 0.65% | ||
| 37 | PRICE T ROWE ASSOCIATES INC /MD/ | 85,606 | 2,685,000 | 0.61% | ||
| 38 | RICE HALL JAMES & ASSOCIATES, LLC | 83,036 | 2,605,000 | 0.59% | ||
| 39 | STATE STREET CORP | 74,003 | 2,320,000 | 0.53% | ||
| 40 | BAMCO INC /NY/ | 65,600 | 2,058,000 | 0.47% | ||
| 41 | BlackRock Investment Management, LLC | 63,973 | 2,007,000 | 0.46% | ||
| 42 | NORTHERN TRUST CORP | 60,389 | 1,895,000 | 0.43% | ||
| 43 | Lisanti Capital Growth, LLC | 60,365 | 1,894,000 | 0.43% | ||
| 44 | DEUTSCHE BANK AG\ | 57,722 | 1,809,000 | 0.41% | ||
| 45 | GEODE CAPITAL MANAGEMENT, LLC | 53,957 | 1,692,000 | 0.39% | ||
| 46 | TWO SIGMA ADVISERS, LP | 50,000 | 1,569,000 | 0.36% | ||
| 47 | CADENCE CAPITAL MANAGEMENT LLC | 48,110 | 1,509,000 | 0.34% | ||
| 48 | TFS CAPITAL LLC | 46,669 | 1,464,000 | 0.33% | ||
| 49 | RUSSELL FRANK CO/ | 46,390 | 1,459,000 | 0.33% | ||
| 50 | Columbia Asset Management | 41,275 | 1,295,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
