| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,549,320 | 113,543,000 | 21.49% | ||
| 2 | TimesSquare Capital Management, LLC | 1,256,400 | 40,192,000 | 7.61% | ||
| 3 | BLAIR WILLIAM & CO/IL | 714,796 | 22,866,000 | 4.33% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 601,772 | 19,251,000 | 3.64% | ||
| 5 | Cortina Asset Management, LLC | 572,189 | 18,304,000 | 3.46% | ||
| 6 | Tamarack Capital Management, LLC | 550,000 | 17,595,000 | 3.33% | ||
| 7 | NINE TEN CAPITAL MANAGEMENT LLC | 539,323 | 17,253,000 | 3.27% | ||
| 8 | COLUMBUS CIRCLE INVESTORS | 438,162 | 14,017,000 | 2.65% | ||
| 9 | Allianz Asset Management GmbH | 427,327 | 13,670,000 | 2.59% | ||
| 10 | FMR LLC | 400,000 | 12,796,000 | 2.42% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 329,614 | 10,544,000 | 2.00% | ||
| 12 | EMERALD ADVISERS, LLC | 272,943 | 10,312,000 | 1.95% | ||
| 13 | ROYCE & ASSOCIATES LP | 316,155 | 10,114,000 | 1.91% | ||
| 14 | LOOMIS SAYLES & CO L P | 315,632 | 10,097,000 | 1.91% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 259,702 | 9,812,000 | 1.86% | ||
| 16 | THORNBURG INVESTMENT MANAGEMENT INC | 282,913 | 9,050,000 | 1.71% | ||
| 17 | CASTLEARK MANAGEMENT LLC | 270,934 | 8,667,000 | 1.64% | ||
| 18 | VANGUARD GROUP INC | 268,782 | 8,598,000 | 1.63% | ||
| 19 | OppenheimerFunds, Inc. | 267,490 | 8,557,000 | 1.62% | ||
| 20 | JPMORGAN CHASE & CO | 263,647 | 8,434,000 | 1.60% | ||
| 21 | Nichols Asset Management LLC | 250,488 | 8,013,000 | 1.52% | ||
| 22 | KORNITZER CAPITAL MANAGEMENT INC /KS | 243,636 | 7,794,000 | 1.48% | ||
| 23 | ROCKEFELLER FINANCIAL SERVICES INC | 230,394 | 7,370,000 | 1.39% | ||
| 24 | MCKINLEY CAPITAL MANAGEMENT LLC | 227,604 | 7,281,000 | 1.38% | ||
| 25 | NEXT CENTURY GROWTH INVESTORS LLC | 201,952 | 6,460,000 | 1.22% | ||
| 26 | WELLS FARGO & COMPANY/MN | 198,045 | 6,336,000 | 1.20% | ||
| 27 | MORGAN STANLEY | 183,161 | 5,860,000 | 1.11% | ||
| 28 | BLACKROCK ADVISORS LLC | 173,615 | 5,554,000 | 1.05% | ||
| 29 | Versant Venture Management, LLC | 155,284 | 4,967,535 | 0.94% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 152,700 | 4,885,000 | 0.92% | ||
| 31 | BlackRock Fund Advisors | 146,473 | 4,686,000 | 0.89% | ||
| 32 | ARBOR CAPITAL MANAGEMENT LLC | 132,485 | 4,238,000 | 0.80% | ||
| 33 | Timpani Capital Management LLC | 123,887 | 3,963,000 | 0.75% | ||
| 34 | THRIVENT FINANCIAL FOR LUTHERANS | 117,500 | 3,759,000 | 0.71% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 113,161 | 3,620,000 | 0.69% | ||
| 36 | Ghost Tree Capital, LLC | 110,000 | 3,519,000 | 0.67% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 83,979 | 2,686,000 | 0.51% | ||
| 38 | PRICE T ROWE ASSOCIATES INC /MD/ | 80,002 | 2,559,000 | 0.48% | ||
| 39 | BlackRock Group LTD | 77,398 | 2,476,000 | 0.47% | ||
| 40 | STATE STREET CORP | 77,026 | 2,465,000 | 0.47% | ||
| 41 | Nuveen Asset Management, LLC | 72,732 | 2,327,000 | 0.44% | ||
| 42 | LORD, ABBETT & CO. LLC | 70,786 | 2,264,000 | 0.43% | ||
| 43 | CITADEL ADVISORS LLC | 70,434 | 2,254,000 | 0.43% | ||
| 44 | GSA CAPITAL PARTNERS LLP | 66,511 | 2,128,000 | 0.40% | ||
| 45 | BAMCO INC /NY/ | 65,600 | 2,099,000 | 0.40% | ||
| 46 | BlackRock Institutional Trust Company, N.A. | 61,350 | 1,963,000 | 0.37% | ||
| 47 | NORTHERN TRUST CORP | 60,488 | 1,935,000 | 0.37% | ||
| 48 | TWO SIGMA ADVISERS, LP | 59,100 | 1,891,000 | 0.36% | ||
| 49 | Point72 Asset Management, L.P. | 56,400 | 1,804,000 | 0.34% | ||
| 50 | RICE HALL JAMES & ASSOCIATES, LLC | 48,973 | 1,567,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
