| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,549,320 | 238,408,000 | 16.72% | ||
| 2 | BROWN CAPITAL MANAGEMENT LLC | 1,417,248 | 95,197,000 | 6.68% | ||
| 3 | BlackRock Fund Advisors | 1,306,177 | 87,736,000 | 6.15% | ||
| 4 | VANGUARD GROUP INC | 1,157,803 | 77,769,000 | 5.45% | ||
| 5 | BLAIR WILLIAM & CO/IL | 904,316 | 60,743,000 | 4.26% | ||
| 6 | TimesSquare Capital Management, LLC | 629,465 | 42,281,000 | 2.97% | ||
| 7 | WADDELL & REED FINANCIAL INC | 625,330 | 42,004,000 | 2.95% | ||
| 8 | DIMENSIONAL FUND ADVISORS LP | 498,616 | 33,492,000 | 2.35% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 417,621 | 28,052,000 | 1.97% | ||
| 10 | LOOMIS SAYLES & CO L P | 383,904 | 25,787,000 | 1.81% | ||
| 11 | Cortina Asset Management, LLC | 379,781 | 25,510,000 | 1.79% | ||
| 12 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 379,246 | 25,474,000 | 1.79% | ||
| 13 | STATE STREET CORP | 368,763 | 24,770,000 | 1.74% | ||
| 14 | JPMORGAN CHASE & CO | 346,364 | 23,265,000 | 1.63% | ||
| 15 | Granahan Investment Management, LLC | 317,801 | 21,347,000 | 1.50% | ||
| 16 | ROYAL BANK OF CANADA | 297,163 | 19,961,000 | 1.40% | ||
| 17 | ROCKEFELLER FINANCIAL SERVICES INC | 294,505 | 19,782,000 | 1.39% | ||
| 18 | WELLS FARGO & COMPANY/MN | 283,279 | 19,028,000 | 1.33% | ||
| 19 | Bank of New York Mellon Corp | 281,658 | 18,919,000 | 1.33% | ||
| 20 | NORGES BANK | 280,079 | 18,813,000 | 1.32% | ||
| 21 | PRICE T ROWE ASSOCIATES INC /MD/ | 278,940 | 18,736,000 | 1.31% | ||
| 22 | Invesco Ltd. | 248,231 | 16,673,000 | 1.17% | ||
| 23 | KALMAR INVESTMENTS INC /DE/ | 247,297 | 16,611,000 | 1.17% | ||
| 24 | NEXT CENTURY GROWTH INVESTORS LLC | 238,642 | 16,029,000 | 1.12% | ||
| 25 | NORTHERN TRUST CORP | 227,176 | 15,260,000 | 1.07% | ||
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 223,101 | 14,986,000 | 1.05% | ||
| 27 | NEW YORK STATE COMMON RETIREMENT FUND | 219,427 | 14,739,000 | 1.03% | ||
| 28 | OppenheimerFunds, Inc. | 215,487 | 14,474,000 | 1.02% | ||
| 29 | FMR LLC | 207,600 | 13,944,000 | 0.98% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 167,299 | 11,237,000 | 0.79% | ||
| 31 | TIRSCHWELL & LOEWY INC | 165,200 | 11,096,000 | 0.78% | ||
| 32 | KORNITZER CAPITAL MANAGEMENT INC /KS | 164,385 | 11,042,000 | 0.77% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 163,786 | 11,001,000 | 0.77% | ||
| 34 | THRIVENT FINANCIAL FOR LUTHERANS | 162,020 | 10,883,000 | 0.76% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 146,700 | 9,854,000 | 0.69% | ||
| 36 | PRINCIPAL FINANCIAL GROUP INC | 129,743 | 8,715,000 | 0.61% | ||
| 37 | Allianz Asset Management GmbH | 119,180 | 8,005,000 | 0.56% | ||
| 38 | AMERIPRISE FINANCIAL INC | 116,762 | 7,843,000 | 0.55% | ||
| 39 | FRED ALGER MANAGEMENT, LLC | 113,322 | 7,612,000 | 0.53% | ||
| 40 | CREDIT AGRICOLE S A | 110,000 | 7,389,000 | 0.52% | ||
| 41 | OBERWEIS ASSET MANAGEMENT INC/ | 107,400 | 7,214,000 | 0.51% | ||
| 42 | MARSHALL WACE, LLP | 102,602 | 6,892,000 | 0.48% | ||
| 43 | DEUTSCHE BANK AG\ | 101,598 | 6,823,000 | 0.48% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 96,858 | 6,506,000 | 0.46% | ||
| 45 | Point72 Asset Management, L.P. | 95,100 | 6,388,000 | 0.45% | ||
| 46 | RUSSELL INVESTMENTS GROUP, LTD. | 94,170 | 6,307,000 | 0.44% | ||
| 47 | LORD, ABBETT & CO. LLC | 93,598 | 6,287,000 | 0.44% | ||
| 48 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 92,350 | 6,203,000 | 0.44% | ||
| 49 | BlackRock Investment Management, LLC | 82,520 | 5,543,000 | 0.39% | ||
| 50 | TWO SIGMA ADVISERS, LP | 79,900 | 5,367,000 | 0.38% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
