| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,549,320 | 172,319,000 | 18.62% | ||
| 2 | BlackRock Fund Advisors | 950,419 | 46,143,000 | 4.99% | ||
| 3 | TimesSquare Capital Management, LLC | 790,000 | 38,355,000 | 4.14% | ||
| 4 | BLAIR WILLIAM & CO/IL | 729,100 | 35,397,000 | 3.83% | ||
| 5 | Allianz Asset Management GmbH | 664,520 | 32,262,000 | 3.49% | ||
| 6 | VANGUARD GROUP INC | 640,970 | 31,119,000 | 3.36% | ||
| 7 | FMR LLC | 557,200 | 27,052,000 | 2.92% | ||
| 8 | WELLS FARGO & COMPANY/MN | 518,950 | 25,195,000 | 2.72% | ||
| 9 | LOOMIS SAYLES & CO L P | 506,446 | 24,588,000 | 2.66% | ||
| 10 | OppenheimerFunds, Inc. | 485,240 | 23,558,000 | 2.55% | ||
| 11 | NEXT CENTURY GROWTH INVESTORS LLC | 468,202 | 22,731,000 | 2.46% | ||
| 12 | Cortina Asset Management, LLC | 429,435 | 20,849,000 | 2.25% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 419,877 | 20,385,000 | 2.20% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 354,864 | 17,229,000 | 1.86% | ||
| 15 | COLUMBUS CIRCLE INVESTORS | 316,181 | 15,351,000 | 1.66% | ||
| 16 | ROYCE & ASSOCIATES LP | 287,455 | 13,956,000 | 1.51% | ||
| 17 | STATE STREET CORP | 282,889 | 13,739,000 | 1.48% | ||
| 18 | Granahan Investment Management, LLC | 278,456 | 13,519,000 | 1.46% | ||
| 19 | JPMORGAN CHASE & CO | 261,450 | 12,694,000 | 1.37% | ||
| 20 | ROCKEFELLER FINANCIAL SERVICES INC | 235,268 | 11,422,000 | 1.23% | ||
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 234,422 | 11,381,000 | 1.23% | ||
| 22 | LORD, ABBETT & CO. LLC | 232,497 | 11,288,000 | 1.22% | ||
| 23 | Nichols Asset Management LLC | 230,765 | 11,204,000 | 1.21% | ||
| 24 | Point72 Asset Management, L.P. | 220,900 | 10,725,000 | 1.16% | ||
| 25 | THORNBURG INVESTMENT MANAGEMENT INC | 214,495 | 10,414,000 | 1.13% | ||
| 26 | NORTHERN TRUST CORP | 208,208 | 10,108,000 | 1.09% | ||
| 27 | MORGAN STANLEY | 199,779 | 9,698,000 | 1.05% | ||
| 28 | CASTLEARK MANAGEMENT LLC | 191,745 | 9,309,000 | 1.01% | ||
| 29 | KALMAR INVESTMENTS INC /DE/ | 189,458 | 9,198,000 | 0.99% | ||
| 30 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 167,996 | 8,156,000 | 0.88% | ||
| 31 | Bank of New York Mellon Corp | 167,673 | 8,141,000 | 0.88% | ||
| 32 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 152,096 | 7,384,000 | 0.80% | ||
| 33 | PRICE T ROWE ASSOCIATES INC /MD/ | 150,400 | 7,302,000 | 0.79% | ||
| 34 | Invesco Ltd. | 149,950 | 7,280,000 | 0.79% | ||
| 35 | THRIVENT FINANCIAL FOR LUTHERANS | 148,650 | 7,217,000 | 0.78% | ||
| 36 | RUSSELL FRANK CO/ | 148,425 | 7,207,000 | 0.78% | ||
| 37 | EMERALD MUTUAL FUND ADVISERS TRUST | 142,820 | 6,934,000 | 0.75% | ||
| 38 | KORNITZER CAPITAL MANAGEMENT INC /KS | 136,900 | 6,646,000 | 0.72% | ||
| 39 | Polar Capital LLP | 136,300 | 6,617,000 | 0.72% | ||
| 40 | EMERALD ADVISERS, LLC | 133,997 | 6,506,000 | 0.70% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 118,757 | 5,765,000 | 0.62% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 118,532 | 5,754,000 | 0.62% | ||
| 43 | Timpani Capital Management LLC | 111,862 | 5,431,000 | 0.59% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,780 | 4,893,000 | 0.53% | ||
| 45 | DEUTSCHE BANK AG\ | 93,300 | 4,528,000 | 0.49% | ||
| 46 | PRINCIPAL FINANCIAL GROUP INC | 88,868 | 4,315,000 | 0.47% | ||
| 47 | AMERIPRISE FINANCIAL INC | 87,320 | 4,240,000 | 0.46% | ||
| 48 | ARBOR CAPITAL MANAGEMENT LLC | 77,400 | 3,758,000 | 0.41% | ||
| 49 | TURNER INVESTMENTS LLC | 76,500 | 3,714,000 | 0.40% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 73,074 | 3,548,000 | 0.38% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
