| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,549,320 | 177,856,000 | 16.40% | ||
| 2 | BROWN CAPITAL MANAGEMENT LLC | 1,199,691 | 60,117,000 | 5.54% | ||
| 3 | TimesSquare Capital Management, LLC | 1,162,120 | 58,234,000 | 5.37% | ||
| 4 | BlackRock Fund Advisors | 1,058,168 | 53,025,000 | 4.89% | ||
| 5 | WELLS FARGO & COMPANY/MN | 946,996 | 47,454,000 | 4.37% | ||
| 6 | BLAIR WILLIAM & CO/IL | 912,871 | 45,744,000 | 4.22% | ||
| 7 | VANGUARD GROUP INC | 891,757 | 44,686,000 | 4.12% | ||
| 8 | DIMENSIONAL FUND ADVISORS LP | 456,991 | 22,899,000 | 2.11% | ||
| 9 | KALMAR INVESTMENTS INC /DE/ | 434,845 | 21,790,000 | 2.01% | ||
| 10 | JPMORGAN CHASE & CO | 427,775 | 21,436,000 | 1.98% | ||
| 11 | LOOMIS SAYLES & CO L P | 421,992 | 21,146,000 | 1.95% | ||
| 12 | Cortina Asset Management, LLC | 415,781 | 20,835,000 | 1.92% | ||
| 13 | FMR LLC | 400,500 | 20,069,000 | 1.85% | ||
| 14 | OppenheimerFunds, Inc. | 398,645 | 19,976,000 | 1.84% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 378,620 | 18,973,000 | 1.75% | ||
| 16 | Granahan Investment Management, LLC | 335,241 | 16,799,000 | 1.55% | ||
| 17 | LORD, ABBETT & CO. LLC | 322,287 | 16,150,000 | 1.49% | ||
| 18 | NEXT CENTURY GROWTH INVESTORS LLC | 319,269 | 15,998,000 | 1.47% | ||
| 19 | STATE STREET CORP | 314,430 | 15,755,000 | 1.45% | ||
| 20 | ROCKEFELLER FINANCIAL SERVICES INC | 295,558 | 14,810,000 | 1.37% | ||
| 21 | Pembroke Management, LTD | 292,500 | 14,657,000 | 1.35% | ||
| 22 | Invesco Ltd. | 284,713 | 14,267,000 | 1.32% | ||
| 23 | Bank of New York Mellon Corp | 265,627 | 13,310,000 | 1.23% | ||
| 24 | ROYAL BANK OF CANADA | 257,941 | 12,926,000 | 1.19% | ||
| 25 | PRICE T ROWE ASSOCIATES INC /MD/ | 239,340 | 11,993,000 | 1.11% | ||
| 26 | NORTHERN TRUST CORP | 221,144 | 11,081,000 | 1.02% | ||
| 27 | WELLINGTON MANAGEMENT GROUP LLP | 217,268 | 10,887,000 | 1.00% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 216,300 | 10,839,000 | 1.00% | ||
| 29 | Allianz Asset Management GmbH | 215,592 | 10,803,000 | 1.00% | ||
| 30 | KORNITZER CAPITAL MANAGEMENT INC /KS | 213,700 | 10,709,000 | 0.99% | ||
| 31 | NEW YORK STATE COMMON RETIREMENT FUND | 207,215 | 10,384,000 | 0.96% | ||
| 32 | THRIVENT FINANCIAL FOR LUTHERANS | 197,230 | 9,883,000 | 0.91% | ||
| 33 | Point72 Asset Management, L.P. | 196,214 | 9,832,000 | 0.91% | ||
| 34 | Polar Capital LLP | 193,524 | 9,697,000 | 0.89% | ||
| 35 | COLUMBUS CIRCLE INVESTORS | 190,500 | 9,546,000 | 0.88% | ||
| 36 | TIRSCHWELL & LOEWY INC | 174,550 | 8,747,000 | 0.81% | ||
| 37 | ROYCE & ASSOCIATES LP | 170,155 | 8,526,000 | 0.79% | ||
| 38 | AMERIPRISE FINANCIAL INC | 145,195 | 7,276,000 | 0.67% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 145,063 | 7,268,000 | 0.67% | ||
| 40 | EverPoint Asset Management, LLC | 143,667 | 7,199,000 | 0.66% | ||
| 41 | WADDELL & REED FINANCIAL INC | 143,300 | 7,181,000 | 0.66% | ||
| 42 | OBERWEIS ASSET MANAGEMENT INC/ | 142,720 | 7,152,000 | 0.66% | ||
| 43 | THORNBURG INVESTMENT MANAGEMENT INC | 129,878 | 6,508,000 | 0.60% | ||
| 44 | CREDIT AGRICOLE S A | 110,000 | 5,512,000 | 0.51% | ||
| 45 | PRINCIPAL FINANCIAL GROUP INC | 106,295 | 5,326,000 | 0.49% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,635 | 5,043,000 | 0.46% | ||
| 47 | DEUTSCHE BANK AG\ | 98,651 | 4,941,000 | 0.46% | ||
| 48 | DRIEHAUS CAPITAL MANAGEMENT LLC | 89,310 | 4,475,000 | 0.41% | ||
| 49 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 88,502 | 4,435,000 | 0.41% | ||
| 50 | Century Capital Management, LLC | 88,007 | 4,410,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
