| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,549,320 | 159,648,000 | 16.66% | ||
| 2 | TimesSquare Capital Management, LLC | 1,186,720 | 53,379,000 | 5.57% | ||
| 3 | BlackRock Fund Advisors | 1,015,022 | 45,656,000 | 4.77% | ||
| 4 | WELLS FARGO & COMPANY/MN | 987,717 | 44,428,000 | 4.64% | ||
| 5 | BLAIR WILLIAM & CO/IL | 918,252 | 41,303,000 | 4.31% | ||
| 6 | VANGUARD GROUP INC | 716,061 | 32,208,000 | 3.36% | ||
| 7 | NEXT CENTURY GROWTH INVESTORS LLC | 659,333 | 29,656,000 | 3.10% | ||
| 8 | KALMAR INVESTMENTS INC /DE/ | 507,043 | 22,807,000 | 2.38% | ||
| 9 | OppenheimerFunds, Inc. | 476,490 | 21,433,000 | 2.24% | ||
| 10 | Point72 Asset Management, L.P. | 467,785 | 21,041,000 | 2.20% | ||
| 11 | JPMORGAN CHASE & CO | 444,075 | 19,975,000 | 2.08% | ||
| 12 | LOOMIS SAYLES & CO L P | 434,822 | 19,559,000 | 2.04% | ||
| 13 | Cortina Asset Management, LLC | 418,736 | 18,835,000 | 1.97% | ||
| 14 | FMR LLC | 400,500 | 18,014,000 | 1.88% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 375,367 | 16,884,000 | 1.76% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 363,200 | 16,337,000 | 1.71% | ||
| 17 | DIMENSIONAL FUND ADVISORS LP | 355,069 | 15,969,000 | 1.67% | ||
| 18 | Granahan Investment Management, LLC | 344,621 | 15,501,000 | 1.62% | ||
| 19 | Allianz Asset Management GmbH | 310,462 | 13,965,000 | 1.46% | ||
| 20 | STATE STREET CORP | 301,532 | 13,559,000 | 1.42% | ||
| 21 | ROCKEFELLER FINANCIAL SERVICES INC | 289,799 | 13,035,000 | 1.36% | ||
| 22 | Bank of New York Mellon Corp | 278,494 | 12,527,000 | 1.31% | ||
| 23 | ROYCE & ASSOCIATES LP | 259,455 | 11,670,000 | 1.22% | ||
| 24 | Pembroke Management, LTD | 244,600 | 11,002,000 | 1.15% | ||
| 25 | KORNITZER CAPITAL MANAGEMENT INC /KS | 237,100 | 10,665,000 | 1.11% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 220,240 | 9,906,000 | 1.03% | ||
| 27 | COLUMBUS CIRCLE INVESTORS | 210,210 | 9,455,000 | 0.99% | ||
| 28 | THORNBURG INVESTMENT MANAGEMENT INC | 208,381 | 9,373,000 | 0.98% | ||
| 29 | Nichols Asset Management LLC | 206,766 | 9,300,000 | 0.97% | ||
| 30 | NORTHERN TRUST CORP | 206,501 | 9,289,000 | 0.97% | ||
| 31 | Invesco Ltd. | 196,091 | 8,820,000 | 0.92% | ||
| 32 | THRIVENT FINANCIAL FOR LUTHERANS | 195,540 | 8,795,000 | 0.92% | ||
| 33 | Polar Capital LLP | 193,524 | 8,705,000 | 0.91% | ||
| 34 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 187,913 | 8,452,000 | 0.88% | ||
| 35 | TIRSCHWELL & LOEWY INC | 175,400 | 7,889,000 | 0.82% | ||
| 36 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 167,688 | 7,045,000 | 0.74% | ||
| 37 | EverPoint Asset Management, LLC | 155,000 | 6,972,000 | 0.73% | ||
| 38 | TWO SIGMA INVESTMENTS, LP | 151,115 | 6,797,000 | 0.71% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 149,106 | 6,706,000 | 0.70% | ||
| 40 | WADDELL & REED FINANCIAL INC | 143,300 | 6,446,000 | 0.67% | ||
| 41 | LORD, ABBETT & CO. LLC | 137,344 | 6,178,000 | 0.64% | ||
| 42 | AMERIPRISE FINANCIAL INC | 135,980 | 6,116,000 | 0.64% | ||
| 43 | OBERWEIS ASSET MANAGEMENT INC/ | 130,960 | 5,891,000 | 0.61% | ||
| 44 | CREDIT AGRICOLE S A | 110,000 | 4,948,000 | 0.52% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,661 | 4,528,000 | 0.47% | ||
| 46 | PRINCIPAL FINANCIAL GROUP INC | 98,249 | 4,419,000 | 0.46% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,172 | 3,562,000 | 0.37% | ||
| 48 | GOLDMAN SACHS GROUP INC | 77,298 | 3,477,000 | 0.36% | ||
| 49 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 75,200 | 3,382,000 | 0.35% | ||
| 50 | ARBOR CAPITAL MANAGEMENT LLC | 71,700 | 3,225,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
