| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 5,419,449 | 111,695,000 | 48.83% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 552,337 | 11,384,000 | 4.98% | ||
| 3 | FMR LLC | 400,000 | 8,244,000 | 3.60% | ||
| 4 | ROYCE & ASSOCIATES LP | 367,155 | 7,567,000 | 3.31% | ||
| 5 | BLACKROCK ADVISORS LLC | 338,870 | 6,984,000 | 3.05% | ||
| 6 | EMERALD ADVISERS, LLC | 272,210 | 5,610,000 | 2.45% | ||
| 7 | EMERALD MUTUAL FUND ADVISERS TRUST | 268,282 | 5,529,000 | 2.42% | ||
| 8 | Tamarack Capital Management, LLC | 260,617 | 5,371,000 | 2.35% | ||
| 9 | JPMORGAN CHASE & CO | 260,495 | 5,368,000 | 2.35% | ||
| 10 | Allianz Asset Management GmbH | 257,734 | 5,312,000 | 2.32% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 251,600 | 5,185,000 | 2.27% | ||
| 12 | Nichols Asset Management LLC | 233,755 | 4,818,000 | 2.11% | ||
| 13 | KORNITZER CAPITAL MANAGEMENT INC /KS | 185,800 | 3,829,000 | 1.67% | ||
| 14 | BlackRock Group LTD | 170,241 | 3,509,000 | 1.53% | ||
| 15 | BLAIR WILLIAM & CO/IL | 153,978 | 3,173,000 | 1.39% | ||
| 16 | Pier Capital, LLC | 144,612 | 2,980,000 | 1.30% | ||
| 17 | CANADA LIFE ASSURANCE Co | 136,633 | 2,775,000 | 1.21% | ||
| 18 | MORGAN STANLEY | 125,620 | 2,589,000 | 1.13% | ||
| 19 | BlackRock Fund Advisors | 123,419 | 2,544,000 | 1.11% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 123,375 | 2,543,000 | 1.11% | ||
| 21 | VANGUARD GROUP INC | 120,128 | 2,475,000 | 1.08% | ||
| 22 | STATE STREET CORP | 67,937 | 1,400,000 | 0.61% | ||
| 23 | CADENCE CAPITAL MANAGEMENT LLC | 66,540 | 1,371,000 | 0.60% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 65,109 | 1,342,000 | 0.59% | ||
| 25 | BlackRock Investment Management, LLC | 63,544 | 1,310,000 | 0.57% | ||
| 26 | EDMUNDS WHITE PARTNERS LLC | 59,868 | 1,234,000 | 0.54% | SH | |
| 27 | NORTHERN TRUST CORP | 56,403 | 1,162,000 | 0.51% | ||
| 28 | BAMCO INC /NY/ | 50,000 | 1,030,000 | 0.45% | ||
| 29 | DEUTSCHE BANK AG\ | 47,132 | 970,000 | 0.42% | ||
| 30 | Informed Momentum Co LLC | 44,239 | 912,000 | 0.40% | ||
| 31 | BlackRock Institutional Trust Company, N.A. | 42,082 | 867,000 | 0.38% | ||
| 32 | Columbia Asset Management | 40,550 | 836,000 | 0.37% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 38,987 | 804,000 | 0.35% | ||
| 34 | RUSSELL FRANK CO/ | 35,872 | 739,000 | 0.32% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 30,289 | 624,000 | 0.27% | ||
| 36 | OPPENHEIMER & CO INC | 25,400 | 523,000 | 0.23% | ||
| 37 | YALE UNIVERSITY | 24,413 | 503,000 | 0.22% | ||
| 38 | FRIESS ASSOCIATES LLC | 22,000 | 453,000 | 0.20% | ||
| 39 | OBERWEIS ASSET MANAGEMENT INC/ | 19,700 | 406,000 | 0.18% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 19,624 | 404,000 | 0.18% | ||
| 41 | GSA CAPITAL PARTNERS LLP | 19,442 | 401,000 | 0.18% | ||
| 42 | Bank of New York Mellon Corp | 18,767 | 387,000 | 0.17% | ||
| 43 | HAMILTON LANE ADVISORS LLC | 14,532 | 300,000 | 0.13% | ||
| 44 | TEACHERS ADVISORS, LLC | 12,389 | 255,000 | 0.11% | ||
| 45 | TFS CAPITAL LLC | 12,286 | 253,000 | 0.11% | ||
| 46 | Board of Trustees of The Leland Stanford Junior University | 12,083 | 249,000 | 0.11% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,454 | 195,000 | 0.09% | ||
| 48 | Nationwide Fund Advisors | 3,901 | 80,000 | 0.03% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 3,343 | 68,899 | 0.03% | ||
| 50 | BARCLAYS PLC | 2,174 | 43,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
