| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 1,740,621 | 20,226,000 | 13.63% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 1,648,700 | 19,158,000 | 12.91% | ||
| 3 | FMR LLC | 1,440,419 | 16,738,000 | 11.28% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,024,482 | 11,904,000 | 8.02% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,016,735 | 11,814,000 | 7.96% | ||
| 6 | Foresite Capital Management I, LLC | 817,300 | 9,497,000 | 6.40% | ||
| 7 | ORBIMED ADVISORS LLC | 801,700 | 9,316,000 | 6.28% | ||
| 8 | QVT Financial LP | 794,600 | 9,233,000 | 6.22% | ||
| 9 | Broadfin Capital, LLC | 774,881 | 9,004,000 | 6.07% | ||
| 10 | BAKER BROS. ADVISORS LP | 542,363 | 6,302,000 | 4.25% | ||
| 11 | VANGUARD GROUP INC | 392,844 | 4,565,000 | 3.08% | ||
| 12 | BlackRock Fund Advisors | 367,661 | 4,272,000 | 2.88% | ||
| 13 | STATE STREET CORP | 239,381 | 2,781,000 | 1.87% | ||
| 14 | SABBY MANAGEMENT, LLC | 209,686 | 2,437,000 | 1.64% | ||
| 15 | JPMORGAN CHASE & CO | 188,842 | 2,195,000 | 1.48% | ||
| 16 | NORTHERN TRUST CORP | 149,829 | 1,741,000 | 1.17% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 133,296 | 1,549,000 | 1.04% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 82,651 | 960,000 | 0.65% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,815 | 649,000 | 0.44% | ||
| 20 | Bank of New York Mellon Corp | 46,910 | 545,000 | 0.37% | ||
| 21 | BlackRock Investment Management, LLC | 42,941 | 499,000 | 0.34% | ||
| 22 | BANQUE PICTET & CIE SA | 29,811 | 346,000 | 0.23% | ||
| 23 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,800 | 311,000 | 0.21% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,900 | 255,000 | 0.17% | ||
| 25 | TEACHERS ADVISORS, LLC | 21,875 | 254,000 | 0.17% | ||
| 26 | GOLDMAN SACHS GROUP INC | 18,869 | 219,000 | 0.15% | ||
| 27 | BLACKROCK ADVISORS LLC | 18,653 | 217,000 | 0.15% | ||
| 28 | TFS CAPITAL LLC | 15,599 | 181,000 | 0.12% | ||
| 29 | Capital Impact Advisors, LLC | 15,461 | 180,000 | 0.12% | ||
| 30 | Trellus Management Company, LLC | 15,000 | 174,000 | 0.12% | ||
| 31 | Nationwide Fund Advisors | 11,341 | 132,000 | 0.09% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,238 | 119,000 | 0.08% | ||
| 33 | AMERICAN INTERNATIONAL GROUP, INC. | 9,585 | 111,378 | 0.08% | ||
| 34 | WELLS FARGO & COMPANY/MN | 6,933 | 80,000 | 0.05% | ||
| 35 | BlackRock Group LTD | 6,087 | 71,000 | 0.05% | ||
| 36 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 6,000 | 70,000 | 0.05% | ||
| 37 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,072 | 70,000 | 0.05% | ||
| 38 | JBF Capital, Inc. | 5,169 | 60,000 | 0.04% | ||
| 39 | DEUTSCHE BANK AG\ | 2,554 | 29,000 | 0.02% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 1,790 | 21,000 | 0.01% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 1,400 | 16,000 | 0.01% | ||
| 42 | UBS AG | 1,350 | 16,000 | 0.01% | ||
| 43 | VIRTUS CAPITAL ADVISERS, LLC | 1,250 | 15,000 | 0.01% | ||
| 44 | CITIGROUP INC | 1,124 | 13,000 | 0.01% | ||
| 45 | BANK OF MONTREAL /CAN/ | 380 | 4,000 | 0.00% | ||
| 46 | BNP PARIBAS FINANCIAL MARKETS | 287 | 3,335 | 0.00% | ||
| 47 | BARCLAYS PLC | 231 | 3,000 | 0.00% | ||
| 48 | ROYAL BANK OF CANADA | 300 | 3,000 | 0.00% | ||
| 49 | STRS OHIO | 300 | 3,000 | 0.00% | ||
| 50 | MORGAN STANLEY | 260 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
