| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 2,962,000 | 45,378,000 | 12.76% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 2,149,423 | 32,929,000 | 9.26% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,954,785 | 29,947,000 | 8.42% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,895,535 | 29,040,000 | 8.17% | ||
| 5 | FMR LLC | 1,440,419 | 22,067,000 | 6.20% | ||
| 6 | ORBIMED ADVISORS LLC | 1,044,615 | 16,004,000 | 4.50% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 919,833 | 14,092,000 | 3.96% | ||
| 8 | BAKER BROS. ADVISORS LP | 872,072 | 13,360,000 | 3.76% | ||
| 9 | VANGUARD GROUP INC | 790,831 | 12,116,000 | 3.41% | ||
| 10 | JENNISON ASSOCIATES LLC | 750,508 | 11,498,000 | 3.23% | ||
| 11 | FRANKLIN RESOURCES INC | 743,201 | 11,386,000 | 3.20% | ||
| 12 | QVT Financial LP | 539,960 | 8,272,000 | 2.33% | ||
| 13 | BlackRock Fund Advisors | 510,817 | 7,826,000 | 2.20% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 7,660,000 | 2.15% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 472,429 | 7,238,000 | 2.04% | ||
| 16 | Alyeska Investment Group, L.P. | 361,065 | 5,532,000 | 1.56% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 341,960 | 5,239,000 | 1.47% | ||
| 18 | Cannell & Co. | 323,885 | 4,962,000 | 1.40% | ||
| 19 | JPMORGAN CHASE & CO | 309,100 | 4,735,000 | 1.33% | ||
| 20 | STATE STREET CORP | 294,505 | 4,510,000 | 1.27% | ||
| 21 | CITADEL ADVISORS LLC | 275,454 | 4,220,000 | 1.19% | ||
| 22 | EVENTIDE ASSET MANAGEMENT, LLC | 258,100 | 3,954,000 | 1.11% | ||
| 23 | Numeric Investors LLC | 210,882 | 3,231,000 | 0.91% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 199,438 | 3,055,000 | 0.86% | ||
| 25 | Rhenman & Partners Asset Management AB | 190,000 | 2,911,000 | 0.82% | ||
| 26 | NORTHERN TRUST CORP | 183,056 | 2,805,000 | 0.79% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 175,301 | 2,685,000 | 0.75% | ||
| 28 | BLACKROCK ADVISORS LLC | 165,937 | 2,542,000 | 0.71% | ||
| 29 | DRIEHAUS CAPITAL MANAGEMENT LLC | 150,046 | 2,299,000 | 0.65% | ||
| 30 | ArrowMark Colorado Holdings LLC | 138,311 | 2,119,000 | 0.60% | ||
| 31 | MORGAN STANLEY | 134,445 | 2,060,000 | 0.58% | ||
| 32 | SPHINX TRADING, LP | 128,018 | 1,961,000 | 0.55% | ||
| 33 | TAYLOR WEALTH MANAGEMENT PARTNERS | 127,490 | 1,953,000 | 0.55% | ||
| 34 | NORGES BANK | 125,078 | 1,916,000 | 0.54% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 106,158 | 1,626,000 | 0.46% | ||
| 36 | Bank of New York Mellon Corp | 80,598 | 1,235,000 | 0.35% | ||
| 37 | D. E. Shaw & Co., Inc. | 78,328 | 1,200,000 | 0.34% | ||
| 38 | SMITH ASSET MANAGEMENT GROUP LP | 77,100 | 1,181,000 | 0.33% | ||
| 39 | OPPENHEIMER & CO INC | 63,760 | 976,000 | 0.27% | ||
| 40 | Informed Momentum Co LLC | 62,473 | 957,000 | 0.27% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,812 | 855,000 | 0.24% | ||
| 42 | MACQUARIE GROUP LTD | 55,000 | 843,000 | 0.24% | ||
| 43 | BlackRock Investment Management, LLC | 54,166 | 830,000 | 0.23% | ||
| 44 | RUSSELL FRANK CO/ | 54,131 | 829,000 | 0.23% | ||
| 45 | PDT Partners, LLC | 52,019 | 797,000 | 0.22% | ||
| 46 | DEUTSCHE BANK AG\ | 51,079 | 782,000 | 0.22% | ||
| 47 | TWO SIGMA ADVISERS, LP | 50,400 | 772,000 | 0.22% | ||
| 48 | Spark Investment Management LLC | 50,300 | 770,000 | 0.22% | ||
| 49 | Birchview Capital, LP | 50,000 | 766,000 | 0.22% | ||
| 50 | AQR CAPITAL MANAGEMENT LLC | 45,200 | 692,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
