| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 5,192,895 | 98,613,000 | 18.39% | ||
| 2 | FMR LLC | 4,398,618 | 83,530,000 | 15.58% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,930,486 | 55,650,000 | 10.38% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,529,574 | 29,046,000 | 5.42% | ||
| 5 | BlackRock Fund Advisors | 1,362,421 | 25,872,000 | 4.82% | ||
| 6 | VANGUARD GROUP INC | 1,343,701 | 25,517,000 | 4.76% | ||
| 7 | BAKER BROS. ADVISORS LP | 872,072 | 16,561,000 | 3.09% | ||
| 8 | ORBIMED ADVISORS LLC | 870,822 | 16,537,000 | 3.08% | ||
| 9 | FRANKLIN RESOURCES INC | 796,801 | 15,131,000 | 2.82% | ||
| 10 | STATE STREET CORP | 626,924 | 11,905,000 | 2.22% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 622,507 | 11,821,000 | 2.20% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 575,316 | 10,925,000 | 2.04% | ||
| 13 | NORGES BANK | 492,730 | 9,357,000 | 1.74% | ||
| 14 | GREAT POINT PARTNERS LLC | 450,000 | 8,546,000 | 1.59% | ||
| 15 | NORTHERN TRUST CORP | 388,049 | 7,370,000 | 1.37% | ||
| 16 | QVT Financial LP | 386,925 | 7,348,000 | 1.37% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 381,009 | 7,235,000 | 1.35% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 367,101 | 6,971,000 | 1.30% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 344,000 | 6,533,000 | 1.22% | ||
| 20 | JPMORGAN CHASE & CO | 288,950 | 5,487,000 | 1.02% | ||
| 21 | Cannell & Co. | 254,800 | 4,839,000 | 0.90% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 236,224 | 4,485,000 | 0.84% | ||
| 23 | Rhenman & Partners Asset Management AB | 225,000 | 4,273,000 | 0.80% | ||
| 24 | ArrowMark Colorado Holdings LLC | 225,002 | 4,273,000 | 0.80% | ||
| 25 | TEACHERS ADVISORS, LLC | 194,443 | 3,692,000 | 0.69% | ||
| 26 | Spark Investment Management LLC | 174,700 | 3,317,000 | 0.62% | ||
| 27 | EcoR1 Capital, LLC | 168,000 | 3,190,000 | 0.59% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 137,810 | 2,617,000 | 0.49% | ||
| 29 | Bank of New York Mellon Corp | 132,627 | 2,519,000 | 0.47% | ||
| 30 | SPHINX TRADING, LP | 128,018 | 2,431,000 | 0.45% | ||
| 31 | BlackRock Investment Management, LLC | 124,815 | 2,370,000 | 0.44% | ||
| 32 | Invesco Ltd. | 121,421 | 2,306,000 | 0.43% | ||
| 33 | D. E. Shaw & Co., Inc. | 114,436 | 2,173,000 | 0.41% | ||
| 34 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | 1,899,000 | 0.35% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 82,990 | 1,576,000 | 0.29% | ||
| 36 | BLACKROCK ADVISORS LLC | 74,465 | 1,414,000 | 0.26% | ||
| 37 | Geneva Advisors, LLC | 69,555 | 1,321,000 | 0.25% | ||
| 38 | ACADIAN ASSET MANAGEMENT LLC | 69,362 | 1,317,000 | 0.25% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,434 | 1,281,000 | 0.24% | ||
| 40 | Informed Momentum Co LLC | 67,467 | 1,281,000 | 0.24% | ||
| 41 | PNC FINANCIAL SERVICES GROUP, INC. | 66,126 | 1,256,000 | 0.23% | ||
| 42 | MACQUARIE GROUP LTD | 55,000 | 1,044,000 | 0.19% | ||
| 43 | Nationwide Fund Advisors | 54,822 | 1,041,000 | 0.19% | ||
| 44 | Swiss National Bank | 54,800 | 1,041,000 | 0.19% | ||
| 45 | EMERALD ACQUISITION LTD. | 50,570 | 960,000 | 0.18% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,428 | 939,000 | 0.18% | ||
| 47 | Vident Investment Advisory, LLC | 48,582 | 923,000 | 0.17% | ||
| 48 | AQR CAPITAL MANAGEMENT LLC | 43,533 | 827,000 | 0.15% | ||
| 49 | DEUTSCHE BANK AG\ | 41,931 | 795,000 | 0.15% | ||
| 50 | MORGAN STANLEY | 39,156 | 743,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
