| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,576,250 | 74,833,000 | 20.00% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 4,731,995 | 63,503,000 | 16.97% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,467,512 | 46,534,000 | 12.44% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,804,784 | 24,220,000 | 6.47% | ||
| 5 | BlackRock Fund Advisors | 1,261,488 | 16,929,000 | 4.52% | ||
| 6 | VANGUARD GROUP INC | 1,145,887 | 15,377,000 | 4.11% | ||
| 7 | ORBIMED ADVISORS LLC | 1,107,022 | 14,856,000 | 3.97% | ||
| 8 | BAKER BROS. ADVISORS LP | 872,072 | 11,703,000 | 3.13% | ||
| 9 | FRANKLIN RESOURCES INC | 858,901 | 11,526,000 | 3.08% | ||
| 10 | STATE STREET CORP | 684,873 | 9,190,000 | 2.46% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 582,320 | 7,815,000 | 2.09% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 576,516 | 7,737,000 | 2.07% | ||
| 13 | GREAT POINT PARTNERS LLC | 528,692 | 7,095,000 | 1.90% | ||
| 14 | QVT Financial LP | 386,925 | 5,193,000 | 1.39% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 344,000 | 4,616,000 | 1.23% | ||
| 16 | NORGES BANK | 340,805 | 4,574,000 | 1.22% | ||
| 17 | NORTHERN TRUST CORP | 329,943 | 4,428,000 | 1.18% | ||
| 18 | Cannell & Co. | 254,800 | 3,419,000 | 0.91% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 216,860 | 2,910,000 | 0.78% | ||
| 20 | ArrowMark Colorado Holdings LLC | 207,610 | 2,786,000 | 0.74% | ||
| 21 | Rhenman & Partners Asset Management AB | 200,000 | 2,684,000 | 0.72% | ||
| 22 | JPMORGAN CHASE & CO | 139,900 | 1,877,000 | 0.50% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,396 | 1,723,000 | 0.46% | ||
| 24 | SPHINX TRADING, LP | 128,018 | 1,718,000 | 0.46% | ||
| 25 | Bank of New York Mellon Corp | 125,662 | 1,687,000 | 0.45% | ||
| 26 | Spark Investment Management LLC | 118,000 | 1,583,000 | 0.42% | ||
| 27 | BlackRock Investment Management, LLC | 100,042 | 1,343,000 | 0.36% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 97,100 | 1,303,000 | 0.35% | ||
| 29 | D. E. Shaw & Co., Inc. | 94,411 | 1,267,000 | 0.34% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 91,631 | 1,230,000 | 0.33% | ||
| 31 | Geneva Advisors, LLC | 75,755 | 1,017,000 | 0.27% | ||
| 32 | BLACKROCK ADVISORS LLC | 68,960 | 925,000 | 0.25% | ||
| 33 | PNC FINANCIAL SERVICES GROUP, INC. | 64,064 | 860,000 | 0.23% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,267 | 809,000 | 0.22% | ||
| 35 | MACQUARIE GROUP LTD | 55,000 | 738,000 | 0.20% | ||
| 36 | Nationwide Fund Advisors | 52,207 | 701,000 | 0.19% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 48,100 | 646,000 | 0.17% | ||
| 38 | Swiss National Bank | 48,400 | 628,000 | 0.17% | ||
| 39 | GOLDMAN SACHS GROUP INC | 44,155 | 593,000 | 0.16% | ||
| 40 | TFS CAPITAL LLC | 43,500 | 584,000 | 0.16% | ||
| 41 | TEACHERS ADVISORS, LLC | 41,285 | 554,000 | 0.15% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 39,728 | 534,000 | 0.14% | ||
| 43 | CREDIT SUISSE AG/ | 37,870 | 508,000 | 0.14% | ||
| 44 | DEERE & CO | 37,602 | 505,000 | 0.13% | ||
| 45 | Creative Planning | 37,400 | 502,000 | 0.13% | ||
| 46 | GSA CAPITAL PARTNERS LLP | 36,700 | 493,000 | 0.13% | ||
| 47 | ProShare Advisors LLC | 33,445 | 449,000 | 0.12% | ||
| 48 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 28,684 | 385,000 | 0.10% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 28,100 | 377,000 | 0.10% | ||
| 50 | RHUMBLINE ADVISERS | 27,311 | 367,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
