| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,687,914 | 102,993,000 | 18.66% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 2,956,500 | 64,954,000 | 11.77% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,884,784 | 41,409,000 | 7.50% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,411,000 | 31,000,000 | 5.62% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,075,410 | 23,627,000 | 4.28% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 1,067,677 | 23,457,000 | 4.25% | ||
| 7 | ORBIMED ADVISORS LLC | 1,044,615 | 22,950,000 | 4.16% | ||
| 8 | BAKER BROS. ADVISORS LP | 872,072 | 19,159,000 | 3.47% | ||
| 9 | FRANKLIN RESOURCES INC | 868,601 | 19,083,000 | 3.46% | ||
| 10 | VANGUARD GROUP INC | 865,504 | 19,015,000 | 3.45% | ||
| 11 | JENNISON ASSOCIATES LLC | 755,505 | 16,598,000 | 3.01% | ||
| 12 | BlackRock Fund Advisors | 743,637 | 16,338,000 | 2.96% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 601,129 | 13,207,000 | 2.39% | ||
| 14 | QVT Financial LP | 539,960 | 11,863,000 | 2.15% | ||
| 15 | STATE STREET CORP | 431,526 | 9,482,000 | 1.72% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 425,286 | 9,344,000 | 1.69% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 327,700 | 7,200,000 | 1.30% | ||
| 18 | Cannell & Co. | 325,725 | 7,156,000 | 1.30% | ||
| 19 | JPMORGAN CHASE & CO | 266,450 | 5,854,000 | 1.06% | ||
| 20 | CITADEL ADVISORS LLC | 247,881 | 5,446,000 | 0.99% | ||
| 21 | LORD, ABBETT & CO. LLC | 237,039 | 5,208,000 | 0.94% | ||
| 22 | NORTHERN TRUST CORP | 218,809 | 4,807,000 | 0.87% | ||
| 23 | Alyeska Investment Group, L.P. | 210,504 | 4,625,000 | 0.84% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 191,900 | 4,216,000 | 0.76% | ||
| 25 | Rhenman & Partners Asset Management AB | 188,000 | 4,130,000 | 0.75% | ||
| 26 | DRIEHAUS CAPITAL MANAGEMENT LLC | 184,444 | 4,052,000 | 0.73% | ||
| 27 | ArrowMark Colorado Holdings LLC | 180,163 | 3,958,000 | 0.72% | ||
| 28 | SPHINX TRADING, LP | 128,018 | 2,813,000 | 0.51% | ||
| 29 | TAYLOR WEALTH MANAGEMENT PARTNERS | 127,110 | 2,793,000 | 0.51% | ||
| 30 | NORGES BANK | 125,078 | 2,748,000 | 0.50% | ||
| 31 | Bank of New York Mellon Corp | 121,685 | 2,673,000 | 0.48% | ||
| 32 | AQR CAPITAL MANAGEMENT LLC | 108,050 | 2,374,000 | 0.43% | ||
| 33 | BlackRock Investment Management, LLC | 100,641 | 2,211,000 | 0.40% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 97,092 | 2,133,000 | 0.39% | ||
| 35 | BLACKROCK ADVISORS LLC | 93,577 | 2,056,000 | 0.37% | ||
| 36 | D. E. Shaw & Co., Inc. | 85,630 | 1,881,000 | 0.34% | ||
| 37 | PDT Partners, LLC | 80,900 | 1,777,000 | 0.32% | ||
| 38 | SMITH ASSET MANAGEMENT GROUP LP | 78,400 | 1,722,000 | 0.31% | ||
| 39 | Invesco Ltd. | 75,390 | 1,656,000 | 0.30% | ||
| 40 | TWO SIGMA ADVISERS, LP | 74,600 | 1,639,000 | 0.30% | ||
| 41 | TWO SIGMA INVESTMENTS, LP | 72,543 | 1,594,000 | 0.29% | ||
| 42 | Informed Momentum Co LLC | 69,444 | 1,526,000 | 0.28% | ||
| 43 | RUSSELL FRANK CO/ | 60,480 | 1,329,000 | 0.24% | ||
| 44 | Nationwide Fund Advisors | 55,175 | 1,212,000 | 0.22% | ||
| 45 | MACQUARIE GROUP LTD | 55,000 | 1,208,000 | 0.22% | ||
| 46 | TFS CAPITAL LLC | 54,760 | 1,203,000 | 0.22% | ||
| 47 | CREDIT SUISSE AG/ | 52,501 | 1,154,000 | 0.21% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,946 | 1,141,000 | 0.21% | ||
| 49 | TEACHERS ADVISORS, LLC | 41,285 | 907,000 | 0.16% | ||
| 50 | MORGAN STANLEY | 40,257 | 885,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
