| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 1,922,707 | 17,900,000 | 14.43% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 1,648,700 | 15,349,000 | 12.37% | ||
| 3 | FMR LLC | 1,440,419 | 13,410,000 | 10.81% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,248,923 | 11,627,000 | 9.37% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,244,482 | 11,586,000 | 9.34% | ||
| 6 | ORBIMED ADVISORS LLC | 838,700 | 7,808,000 | 6.30% | ||
| 7 | Foresite Capital Management I, LLC | 807,356 | 7,516,000 | 6.06% | ||
| 8 | Broadfin Capital, LLC | 753,683 | 7,017,000 | 5.66% | ||
| 9 | QVT Financial LP | 760,000 | 6,708,000 | 5.41% | ||
| 10 | BAKER BROS. ADVISORS LP | 542,363 | 5,049,000 | 4.07% | ||
| 11 | VANGUARD GROUP INC | 405,247 | 3,773,000 | 3.04% | ||
| 12 | BlackRock Fund Advisors | 352,717 | 3,284,000 | 2.65% | ||
| 13 | STATE STREET CORP | 246,179 | 2,294,000 | 1.85% | ||
| 14 | SABBY MANAGEMENT, LLC | 171,275 | 1,595,000 | 1.29% | ||
| 15 | JPMORGAN CHASE & CO | 170,650 | 1,589,000 | 1.28% | ||
| 16 | NORTHERN TRUST CORP | 159,993 | 1,490,000 | 1.20% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 125,352 | 1,167,000 | 0.94% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 86,593 | 806,000 | 0.65% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,815 | 520,000 | 0.42% | ||
| 20 | Bank of New York Mellon Corp | 49,810 | 464,000 | 0.37% | ||
| 21 | GOLDMAN SACHS GROUP INC | 49,153 | 458,000 | 0.37% | ||
| 22 | BlackRock Investment Management, LLC | 43,295 | 403,000 | 0.32% | ||
| 23 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,954 | 251,000 | 0.20% | ||
| 24 | Alyeska Investment Group, L.P. | 23,667 | 220,000 | 0.18% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,900 | 204,000 | 0.16% | ||
| 26 | TEACHERS ADVISORS, LLC | 21,875 | 204,000 | 0.16% | ||
| 27 | BLACKROCK ADVISORS LLC | 18,375 | 171,000 | 0.14% | ||
| 28 | D. E. Shaw & Co., Inc. | 17,813 | 166,000 | 0.13% | ||
| 29 | Capital Impact Advisors, LLC | 15,461 | 144,000 | 0.12% | ||
| 30 | OPPENHEIMER & CO INC | 12,100 | 113,000 | 0.09% | ||
| 31 | Nationwide Fund Advisors | 11,545 | 107,000 | 0.09% | ||
| 32 | A.R.T. Advisors, LLC | 10,272 | 95,000 | 0.08% | ||
| 33 | RHUMBLINE ADVISERS | 10,065 | 94,000 | 0.08% | ||
| 34 | AMERICAN INTERNATIONAL GROUP, INC. | 9,577 | 89,162 | 0.07% | ||
| 35 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,503 | 89,000 | 0.07% | ||
| 36 | WELLS FARGO & COMPANY/MN | 6,476 | 60,000 | 0.05% | ||
| 37 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 6,000 | 56,000 | 0.05% | ||
| 38 | DEUTSCHE BANK AG\ | 4,360 | 40,000 | 0.03% | ||
| 39 | Tower Research Capital LLC (TRC) | 4,230 | 40,000 | 0.03% | ||
| 40 | MORGAN STANLEY | 3,325 | 31,000 | 0.02% | ||
| 41 | UBS AG | 1,637 | 15,000 | 0.01% | ||
| 42 | BNP PARIBAS FINANCIAL MARKETS | 1,121 | 10,437 | 0.01% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 800 | 7,000 | 0.01% | ||
| 44 | CITIGROUP INC | 511 | 5,000 | 0.00% | ||
| 45 | STRS OHIO | 300 | 3,000 | 0.00% | ||
| 46 | ROYAL BANK OF CANADA | 300 | 3,000 | 0.00% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 207 | 2,000 | 0.00% | ||
| 48 | Ground Swell Capital, LLC | 100 | 1,000 | 0.00% | ||
| 49 | BARCLAYS PLC | 152 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
