| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 2,725,000 | 31,964,000 | 18.18% | ||
| 2 | FMR LLC | 2,272,708 | 26,659,000 | 15.16% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 1,767,500 | 20,733,000 | 11.79% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,488,672 | 17,462,000 | 9.93% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 920,000 | 10,792,000 | 6.14% | ||
| 6 | Foresite Capital Management I, LLC | 820,000 | 9,619,000 | 5.47% | ||
| 7 | ORBIMED ADVISORS LLC | 801,700 | 9,404,000 | 5.35% | ||
| 8 | QVT Financial LP | 800,000 | 9,384,000 | 5.34% | ||
| 9 | Broadfin Capital, LLC | 774,881 | 9,089,000 | 5.17% | ||
| 10 | BAKER BROS. ADVISORS LP | 542,363 | 6,362,000 | 3.62% | ||
| 11 | BlackRock Fund Advisors | 401,042 | 4,704,000 | 2.68% | ||
| 12 | VANGUARD GROUP INC | 252,277 | 2,959,000 | 1.68% | ||
| 13 | JPMORGAN CHASE & CO | 196,050 | 2,300,000 | 1.31% | ||
| 14 | Alyeska Investment Group, L.P. | 144,568 | 1,696,000 | 0.96% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 132,103 | 1,550,000 | 0.88% | ||
| 16 | STATE STREET CORP | 104,935 | 1,232,000 | 0.70% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 1,173,000 | 0.67% | ||
| 18 | VHCP Management, LLC | 88,400 | 1,037,000 | 0.59% | ||
| 19 | GOLDMAN SACHS GROUP INC | 83,717 | 982,000 | 0.56% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 71,551 | 839,000 | 0.48% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 65,394 | 767,000 | 0.44% | ||
| 22 | SAC Capital Advisors LP | 57,387 | 673,000 | 0.38% | ||
| 23 | NORTHERN TRUST CORP | 56,627 | 664,000 | 0.38% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,588 | 570,000 | 0.32% | ||
| 25 | BlackRock Investment Management, LLC | 39,394 | 462,000 | 0.26% | ||
| 26 | Bank of New York Mellon Corp | 39,185 | 459,000 | 0.26% | ||
| 27 | DEUTSCHE BANK AG\ | 37,036 | 433,000 | 0.25% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,600 | 312,000 | 0.18% | ||
| 29 | Spark Investment Management LLC | 26,600 | 311,000 | 0.18% | ||
| 30 | BANQUE PICTET & CIE SA | 25,356 | 297,000 | 0.17% | ||
| 31 | TEACHERS ADVISORS, LLC | 24,350 | 286,000 | 0.16% | ||
| 32 | BLACKROCK ADVISORS LLC | 11,470 | 135,000 | 0.08% | ||
| 33 | TFS CAPITAL LLC | 11,181 | 131,000 | 0.07% | ||
| 34 | WELLS FARGO & COMPANY/MN | 9,800 | 115,000 | 0.07% | ||
| 35 | MORGAN STANLEY | 8,537 | 100,000 | 0.06% | ||
| 36 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 6,000 | 70,000 | 0.04% | ||
| 37 | Nationwide Fund Advisors | 4,494 | 53,000 | 0.03% | ||
| 38 | STRS OHIO | 3,600 | 42,000 | 0.02% | ||
| 39 | MOORE CAPITAL MANAGEMENT, LP | 1,192 | 14,000 | 0.01% | ||
| 40 | BARCLAYS PLC | 400 | 4,000 | 0.00% | ||
| 41 | ROYAL BANK OF CANADA | 300 | 4,000 | 0.00% | ||
| 42 | THOMPSON DAVIS & CO., INC. | 250 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
