| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,065,704 | 74,184,000 | 21.42% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 2,967,300 | 36,290,000 | 10.48% | ||
| 3 | STATE STREET CORP | 1,972,826 | 24,130,000 | 6.97% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,787,000 | 21,855,000 | 6.31% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 1,754,784 | 21,461,000 | 6.20% | ||
| 6 | ORBIMED ADVISORS LLC | 1,130,022 | 13,820,000 | 3.99% | ||
| 7 | VANGUARD GROUP INC | 1,025,199 | 12,538,000 | 3.62% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 942,777 | 11,530,000 | 3.33% | ||
| 9 | BAKER BROS. ADVISORS LP | 872,072 | 10,665,000 | 3.08% | ||
| 10 | FRANKLIN RESOURCES INC | 858,901 | 10,504,000 | 3.03% | ||
| 11 | JENNISON ASSOCIATES LLC | 746,762 | 9,133,000 | 2.64% | ||
| 12 | BlackRock Fund Advisors | 743,769 | 9,096,000 | 2.63% | ||
| 13 | RA CAPITAL MANAGEMENT, L.P. | 679,885 | 8,315,000 | 2.40% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 583,646 | 7,138,000 | 2.06% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 484,930 | 5,931,000 | 1.71% | ||
| 16 | QVT Financial LP | 386,925 | 4,732,000 | 1.37% | ||
| 17 | DEUTSCHE BANK AG\ | 370,685 | 4,532,000 | 1.31% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 366,600 | 4,484,000 | 1.29% | ||
| 19 | Cannell & Co. | 340,950 | 4,170,000 | 1.20% | ||
| 20 | LORD, ABBETT & CO. LLC | 330,772 | 4,045,000 | 1.17% | ||
| 21 | NORTHERN TRUST CORP | 306,607 | 3,750,000 | 1.08% | ||
| 22 | MORGAN STANLEY | 289,630 | 3,542,000 | 1.02% | ||
| 23 | DRIEHAUS CAPITAL MANAGEMENT LLC | 203,852 | 2,493,000 | 0.72% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 202,414 | 2,475,000 | 0.71% | ||
| 25 | ArrowMark Colorado Holdings LLC | 194,669 | 2,381,000 | 0.69% | ||
| 26 | Rhenman & Partners Asset Management AB | 181,303 | 2,217,000 | 0.64% | ||
| 27 | JPMORGAN CHASE & CO | 158,997 | 1,945,000 | 0.56% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 150,353 | 1,839,000 | 0.53% | ||
| 29 | SPHINX TRADING, LP | 128,018 | 1,566,000 | 0.45% | ||
| 30 | NORGES BANK | 125,078 | 1,530,000 | 0.44% | ||
| 31 | TAYLOR WEALTH MANAGEMENT PARTNERS | 125,060 | 1,529,000 | 0.44% | ||
| 32 | D. E. Shaw & Co., Inc. | 110,458 | 1,351,000 | 0.39% | ||
| 33 | BlackRock Investment Management, LLC | 99,435 | 1,216,000 | 0.35% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 98,912 | 1,209,000 | 0.35% | ||
| 35 | Bank of New York Mellon Corp | 97,591 | 1,194,000 | 0.34% | ||
| 36 | GOLDMAN SACHS GROUP INC | 94,670 | 1,158,000 | 0.33% | ||
| 37 | PDT Partners, LLC | 94,686 | 1,158,000 | 0.33% | ||
| 38 | BLACKROCK ADVISORS LLC | 93,237 | 1,140,000 | 0.33% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 92,500 | 1,131,000 | 0.33% | ||
| 40 | MILLENNIUM MANAGEMENT LLC | 71,667 | 876,000 | 0.25% | ||
| 41 | TWO SIGMA ADVISERS, LP | 62,700 | 779,000 | 0.22% | ||
| 42 | A.R.T. Advisors, LLC | 61,349 | 750,000 | 0.22% | ||
| 43 | MACQUARIE GROUP LTD | 55,000 | 673,000 | 0.19% | ||
| 44 | Nationwide Fund Advisors | 54,070 | 661,000 | 0.19% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,746 | 633,000 | 0.18% | ||
| 46 | PERCEPTIVE ADVISORS LLC | 50,000 | 612,000 | 0.18% | Put | |
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,320 | 554,000 | 0.16% | ||
| 48 | TEACHERS ADVISORS, LLC | 41,285 | 505,000 | 0.15% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,028 | 490,000 | 0.14% | ||
| 50 | CITIGROUP INC | 35,710 | 438,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
