| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 5,768,822 | 151,835,000 | 16.48% | ||
| 2 | FMR LLC | 3,954,429 | 104,081,000 | 11.30% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,561,446 | 67,417,000 | 7.32% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,020,000 | 53,166,000 | 5.77% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 1,785,018 | 46,982,000 | 5.10% | ||
| 6 | BlackRock Fund Advisors | 1,730,474 | 45,546,000 | 4.94% | ||
| 7 | VANGUARD GROUP INC | 1,531,670 | 40,313,000 | 4.38% | ||
| 8 | Redmile Group, LLC | 996,100 | 26,217,000 | 2.85% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 900,309 | 23,696,000 | 2.57% | ||
| 10 | BAKER BROS. ADVISORS LP | 872,072 | 22,953,000 | 2.49% | ||
| 11 | STATE STREET CORP | 844,845 | 22,234,000 | 2.41% | ||
| 12 | ORBIMED ADVISORS LLC | 840,237 | 22,115,000 | 2.40% | ||
| 13 | FRANKLIN RESOURCES INC | 644,332 | 16,959,000 | 1.84% | ||
| 14 | NORGES BANK | 592,730 | 15,601,000 | 1.69% | ||
| 15 | NORTHERN TRUST CORP | 444,757 | 11,706,000 | 1.27% | ||
| 16 | EcoR1 Capital, LLC | 375,000 | 9,870,000 | 1.07% | ||
| 17 | Invesco Ltd. | 357,457 | 9,409,000 | 1.02% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 344,000 | 9,054,000 | 0.98% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 340,131 | 8,951,000 | 0.97% | ||
| 20 | QVT Financial LP | 338,525 | 8,910,000 | 0.97% | ||
| 21 | TEACHERS ADVISORS, LLC | 319,914 | 8,420,000 | 0.91% | ||
| 22 | JPMORGAN CHASE & CO | 286,800 | 7,548,000 | 0.82% | ||
| 23 | ArrowMark Colorado Holdings LLC | 277,792 | 7,311,000 | 0.79% | ||
| 24 | WELLS FARGO & COMPANY/MN | 259,737 | 6,837,000 | 0.74% | ||
| 25 | Gotham Asset Management, LLC | 248,375 | 6,537,000 | 0.71% | ||
| 26 | Cannell & Co. | 246,500 | 6,488,000 | 0.70% | ||
| 27 | LORD, ABBETT & CO. LLC | 235,753 | 6,206,000 | 0.67% | ||
| 28 | DRIEHAUS CAPITAL MANAGEMENT LLC | 233,906 | 6,156,000 | 0.67% | ||
| 29 | WELLINGTON MANAGEMENT GROUP LLP | 228,560 | 6,015,000 | 0.65% | ||
| 30 | Rhenman & Partners Asset Management AB | 225,000 | 5,922,000 | 0.64% | ||
| 31 | ACADIAN ASSET MANAGEMENT LLC | 208,906 | 5,496,000 | 0.60% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 199,537 | 5,252,000 | 0.57% | ||
| 33 | DIMENSIONAL FUND ADVISORS LP | 182,256 | 4,797,000 | 0.52% | ||
| 34 | ALLIANCEBERNSTEIN L.P. | 182,120 | 4,793,000 | 0.52% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 178,463 | 4,697,000 | 0.51% | ||
| 36 | GOLDMAN SACHS GROUP INC | 174,840 | 4,602,000 | 0.50% | ||
| 37 | Bank of New York Mellon Corp | 171,879 | 4,524,000 | 0.49% | ||
| 38 | AQR CAPITAL MANAGEMENT LLC | 147,837 | 3,891,000 | 0.42% | ||
| 39 | MONASHEE INVESTMENT MANAGEMENT LLC | 139,900 | 3,682,000 | 0.40% | ||
| 40 | BlackRock Investment Management, LLC | 134,806 | 3,548,000 | 0.39% | ||
| 41 | OXFORD ASSET MANAGEMENT LLP | 127,697 | 3,361,000 | 0.36% | ||
| 42 | MAVERICK CAPITAL LTD | 127,380 | 3,353,000 | 0.36% | ||
| 43 | Avoro Capital Advisors LLC | 125,000 | 3,290,000 | 0.36% | ||
| 44 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 116,257 | 3,059,000 | 0.33% | ||
| 45 | MORGAN STANLEY | 105,761 | 2,784,000 | 0.30% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 103,387 | 2,721,000 | 0.30% | ||
| 47 | Cormorant Asset Management, LP | 100,000 | 2,632,000 | 0.29% | ||
| 48 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 89,300 | 2,350,000 | 0.26% | ||
| 49 | FIRST TRUST ADVISORS LP | 89,174 | 2,347,000 | 0.25% | ||
| 50 | PNC FINANCIAL SERVICES GROUP, INC. | 85,092 | 2,239,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
