| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 5,197,595 | 127,289,000 | 17.55% | ||
| 2 | FMR LLC | 4,362,305 | 106,833,000 | 14.73% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,210,900 | 54,145,000 | 7.47% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,496,229 | 36,643,000 | 5.05% | ||
| 5 | BlackRock Fund Advisors | 1,437,156 | 35,196,000 | 4.85% | ||
| 6 | VANGUARD GROUP INC | 1,355,081 | 33,186,000 | 4.58% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 875,676 | 21,445,000 | 2.96% | ||
| 8 | BAKER BROS. ADVISORS LP | 872,072 | 21,357,000 | 2.95% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 809,027 | 19,813,000 | 2.73% | ||
| 10 | STATE STREET CORP | 786,216 | 19,257,000 | 2.66% | ||
| 11 | FRANKLIN RESOURCES INC | 765,451 | 18,746,000 | 2.59% | ||
| 12 | ORBIMED ADVISORS LLC | 744,522 | 18,233,000 | 2.51% | ||
| 13 | NORGES BANK | 542,730 | 12,695,000 | 1.75% | ||
| 14 | NORTHERN TRUST CORP | 389,439 | 9,537,000 | 1.32% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 377,829 | 9,253,000 | 1.28% | ||
| 16 | ACADIAN ASSET MANAGEMENT LLC | 361,540 | 8,853,000 | 1.22% | ||
| 17 | QVT Financial LP | 356,873 | 8,740,000 | 1.21% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 344,000 | 8,425,000 | 1.16% | ||
| 19 | TEACHERS ADVISORS, LLC | 313,522 | 7,678,000 | 1.06% | ||
| 20 | JPMORGAN CHASE & CO | 302,600 | 7,410,000 | 1.02% | ||
| 21 | Invesco Ltd. | 284,516 | 6,968,000 | 0.96% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 272,726 | 6,678,000 | 0.92% | ||
| 23 | Cannell & Co. | 254,800 | 6,240,000 | 0.86% | ||
| 24 | ArrowMark Colorado Holdings LLC | 232,847 | 5,702,000 | 0.79% | ||
| 25 | Rhenman & Partners Asset Management AB | 225,000 | 5,510,250 | 0.76% | ||
| 26 | OXFORD ASSET MANAGEMENT LLP | 194,070 | 4,753,000 | 0.66% | ||
| 27 | LORD, ABBETT & CO. LLC | 173,816 | 4,257,000 | 0.59% | ||
| 28 | Gotham Asset Management, LLC | 161,180 | 3,947,000 | 0.54% | ||
| 29 | D. E. Shaw & Co., Inc. | 156,547 | 3,834,000 | 0.53% | ||
| 30 | ALLIANCEBERNSTEIN L.P. | 153,290 | 3,754,000 | 0.52% | ||
| 31 | EMERALD ACQUISITION LTD. | 150,537 | 3,687,000 | 0.51% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 149,582 | 3,663,000 | 0.51% | ||
| 33 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 143,633 | 3,517,000 | 0.48% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 140,431 | 3,440,000 | 0.47% | ||
| 35 | GOLDMAN SACHS GROUP INC | 138,789 | 3,399,000 | 0.47% | ||
| 36 | Bank of New York Mellon Corp | 135,249 | 3,312,000 | 0.46% | ||
| 37 | BlackRock Investment Management, LLC | 125,211 | 3,066,000 | 0.42% | ||
| 38 | SPHINX TRADING, LP | 125,018 | 3,062,000 | 0.42% | ||
| 39 | DRIEHAUS CAPITAL MANAGEMENT LLC | 115,336 | 2,825,000 | 0.39% | ||
| 40 | WELLS FARGO & COMPANY/MN | 110,163 | 2,698,000 | 0.37% | ||
| 41 | AQR CAPITAL MANAGEMENT LLC | 108,932 | 2,667,000 | 0.37% | ||
| 42 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 102,300 | 2,504,000 | 0.35% | ||
| 43 | PNC FINANCIAL SERVICES GROUP, INC. | 86,291 | 2,113,000 | 0.29% | ||
| 44 | BLACKROCK ADVISORS LLC | 76,228 | 1,867,000 | 0.26% | ||
| 45 | MACKENZIE FINANCIAL CORP | 74,620 | 1,827,000 | 0.25% | ||
| 46 | GSA CAPITAL PARTNERS LLP | 70,200 | 1,719,000 | 0.24% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,134 | 1,669,000 | 0.23% | ||
| 48 | Spark Investment Management LLC | 67,400 | 1,650,000 | 0.23% | ||
| 49 | Geneva Advisors, LLC | 65,555 | 1,605,000 | 0.22% | ||
| 50 | TFS CAPITAL LLC | 62,808 | 1,538,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
